An efficient laboratory-scale preparative method for [1-13C]glycocholic acid

A breath test using [1‐13C]glycocholic acid as a substrate is a potential diagnostic method for small intestinal bacterial overgrowth syndrome. [1‐13C]Glycocholic acid has been thus synthesized in an excellent yield from ethyl [1‐13C]glycinate hydrochloride in a one‐pot reaction. This method is suit...

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Bibliographic Details
Published in:	Journal of labelled compounds & radiopharmaceuticals Vol. 56; no. 11; pp. 587 - 588
Main Authors:	Mitome, Hidemichi, Tokumasu, Naoko, Tando, Yusuke, Nakamura, Teruo, Akira, Kazuki
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-09-2013 Wiley Subscription Services, Inc
Subjects:	breath test Breath tests Carbon Radioisotopes - chemistry carbon-13 glycocholic acid Glycocholic Acid - chemical synthesis Isotope Labeling - methods laboratory scale Medical treatment one-pot reaction stable labeled synthesis glycocholic acid one-pot reaction carbon-13 breath test laboratory scale stable labeled synthesis
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Summary:	A breath test using [1‐13C]glycocholic acid as a substrate is a potential diagnostic method for small intestinal bacterial overgrowth syndrome. [1‐13C]Glycocholic acid has been thus synthesized in an excellent yield from ethyl [1‐13C]glycinate hydrochloride in a one‐pot reaction. This method is suitable for the preparation of the labeled compound on a laboratory scale, which helps to perform extensive clinical studies of the breath test. [1‐13C]Glycocholic acid has been synthesized in an excellent yield from ethyl [1‐13C]glycinate hydrochloride in a one‐pot reaction.
Bibliography:	ArticleID:JLCR3072 ark:/67375/WNG-G86VXW0D-4 istex:070B26361F755697F187ADBA205403116D1070EA ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.3072