Search Results - "Tokuda, Akihisa"

Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology by Kajino, Keita, Tokuda, Akihisa, Saitoh, Tsuyoshi

“…Abstract Morphinan-based opioids, derived from natural alkaloids like morphine, codeine and thebaine, have long been pivotal in managing severe pain. However,…”
Get full text

Design and Synthesis of Orexin 1 Receptor-Selective Agonists by Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi

“…Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness as well as emotional and feeding behavior, and that…”
Get full text

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy by Yamamoto, Hikari, Nagumo, Yasuyuki, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Namekawa, Yukiko, Nemoto, Tsuyoshi, Tanaka, Hiromu, Takahashi, Genki, Tokuda, Akihisa, Saitoh, Tsuyoshi, Nagase, Hiroshi, Funato, Hiromasa, Yanagisawa, Masashi

“…Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using…”
Get full text

Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands by Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi

“…[Display omitted] Mas-related G protein-coupled receptor X2 (MRGPRX2) mediates the itch response in neurons and is involved in atopic dermatitis…”
Get full text

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library by Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

“…Structurally diverse small compounds are utilized to obtain hit compounds that have suitable pharmacophores in appropriate three-dimensional conformations for…”
Get full text

Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands by Maeda, Kenta, Sugai, Tomoya, Tokuda, Akihisa, Kajino, Keita, Saitoh, Tsuyoshi, Nagase, Hiroshi, Kutsumura, Noriki

“…[Display omitted] The morphinan skeleton is valued in drug discovery for its beneficial physicochemical properties and is recognized as a crucial template for…”
Get full text

Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton by Maeda, Kenta, Ohrui, Sayaka, Tokuda, Akihisa, Nagumo, Yasuyuki, Yamamoto, Naoshi, Tanimura, Ryuji, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagase, Hiroshi

“…The reaction of 14-aminonaltrexone with acetic anhydride was found to produce a range of different novel compounds between the free compound and its…”
Get full text

Resonant x-ray diffraction study of the strongly spin-orbit-coupled mott insulator CaIrO3 by Ohgushi, Kenya, Yamaura, Jun-ichi, Ohsumi, Hiroyuki, Sugimoto, Kunihisa, Takeshita, Soshi, Tokuda, Akihisa, Takagi, Hidenori, Takata, Masaki, Arima, Taka-hisa

“…We performed resonant x-ray diffraction experiments at the L absorption edges for the post-perovskite-type compound CaIrO(3) with a (t(2g))^{5} electronic…”
Get full text

Three-Dimensional Near-Surface Imaging of Chirality Domains with Circularly Polarized X-rays by Ohsumi, Hiroyuki, Tokuda, Akihisa, Takeshita, Soshi, Takata, Masaki, Suzuki, Motohiro, Kawamura, Naomi, Kousaka, Yusuke, Akimitsu, Jun, Arima, Taka-hisa

“…Imaging of chirality domains: Resonant circularly polarized X‐ray diffraction distinguishes crystalline enantiomers (see picture). Control of the penetration…”
Get full text

Effects of Molar Mass of Poly(l-lactide acid) on the Crystallization of Poly[(R)-3-hydroxybutyrate] in Their Ultrathin Blend Films by Sun, Xiaoli, Tokuda, Akihisa, Oji, Yusuke, Nakatani, Takashi, Tsuji, Hideto, Ozaki, Yukihiro, Yan, Shouke, Takahashi, Isao

“…Blends of poly[(R)-3-hydroxybutyrate] (PHB) with poly(l-lactide acid) (PLLA) were prepared to study the crystallization behavior of PHB in the blends. To…”
Get full text

Resonant X-ray Diffraction Study of the Strongly Spin-Orbit-Coupled Mott Insulator CaIrO 3 by Ohgushi, Kenya, Yamaura, Jun-ichi, Ohsumi, Hiroyuki, Sugimoto, Kunihisa, Takeshita, Soshi, Tokuda, Akihisa, Takagi, Hidenori, Takata, Masaki, Arima, Taka-hisa

Get full text

Three-Dimensional Near-Surface Imaging of Chirality Domains with Circularly Polarized X-rays by Ohsumi, Hiroyuki, Tokuda, Akihisa, Takeshita, Soshi, Takata, Masaki, Suzuki, Motohiro, Kawamura, Naomi, Kousaka, Yusuke, Akimitsu, Jun, Arima, Taka-hisa

“…Abbildung von chiralen Domänen: Resonante zirkular polarisierte Röntgenbeugung wurde verwendet, um zwischen kristallinen Enantiomeren zu unterscheiden (siehe…”
Get full text

Three‐Dimensional Near‐Surface Imaging of Chirality Domains with Circularly Polarized X‐rays by Ohsumi, Hiroyuki, Tokuda, Akihisa, Takeshita, Soshi, Takata, Masaki, Suzuki, Motohiro, Kawamura, Naomi, Kousaka, Yusuke, Akimitsu, Jun, Arima, Taka‐hisa

Get full text

Resonant X-Ray Diffraction Study of Strongly Spin-Orbit-Coupled Mott Insulator CaIrO3 by Ohgushi, Kenya, Yamaura, Jun-ichi, Ohsumi, Hiroyuki, Sugimoto, Kunihisa, Takeshita, Soshi, Tokuda, Akihisa, Takagi, Hidenori, Takata, Masaki, Arima, Taka-hisa

“…We performed resonant x-ray diffraction experiments at the $L$ absorption edges for the post-perovskite-type compound CaIrO$_{3}$ with $(t_{2g})^5$ electronic…”
Get full text