Crosslinking of hydrophilic polymers using polyperoxides

Crosslinking of hydrophilic polymers using polyperoxides

Hydrogels that can mimic mechanical properties and functions of biological tissue have attracted great interest in tissue engineering and biofabrication. In these fields, new materials and approaches to prepare hydrogels without using toxic starting materials or materials that decompose into toxic c...

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Bibliographic Details
Published in:Colloid and polymer science Vol. 298; no. 12; pp. 1699 - 1713
Main Authors: Borova, Solomiia, Tokarev, Victor, Stahlhut, Philipp, Luxenhofer, Robert
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2020
Springer Nature B.V
Subjects:
Biological properties
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Copolymers
Crosslinking
Food Science
Hydrogels
Hydrophilicity
Mechanical properties
Medical materials
Nanotechnology and Microengineering
Original Contribution
Physical Chemistry
Polyethyloxazoline
Polymer Sciences
Polymers
Soft and Granular Matter
Tissue engineering
Thermal crosslinking
Hydrogels
Peroxide containing copolymers
Poly(2-ethyl-2-oxazoline)
Radical crosslinking
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Summary:Hydrogels that can mimic mechanical properties and functions of biological tissue have attracted great interest in tissue engineering and biofabrication. In these fields, new materials and approaches to prepare hydrogels without using toxic starting materials or materials that decompose into toxic compounds remain to be sought after. Here, we report the crosslinking of commercial, unfunctionalized hydrophilic poly(2-ethyl-2-oxazoline) using peroxide copolymers in their melt. The influence of temperature, peroxide copolymer concentration, and duration of the crosslinking process has been investigated. The method allows to create hydrogels from unfunctionalized polymers in their melt and to control the mechanical properties of the resulting materials. The design of hydrogels with a suitable mechanical performance is of crucial importance in many existing and potential applications of soft materials, including medical applications.
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-020-04738-w