Search Results - "Tohkin, M."

Ethnic Difference in the Pharmacodynamics‐efficacy Relationship of Dipeptidyl Peptidase‐4 Inhibitors Between Japanese and non‐Japanese Patients: A Systematic Review by Ito, Y, Ambe, K, Kobayashi, M, Tohkin, M

“…A systematic review of the differences in the efficacy of dipeptidyl peptidase‐4 (DPP‐4) inhibitors between Japanese and non‐Japanese subjects was conducted…”
Get full text

A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients by Tohkin, M, Kaniwa, N, Saito, Y, Sugiyama, E, Kurose, K, Nishikawa, J, Hasegawa, R, Aihara, M, Matsunaga, K, Abe, M, Furuya, H, Takahashi, Y, Ikeda, H, Muramatsu, M, Ueta, M, Sotozono, C, Kinoshita, S, Ikezawa, Z

“…Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe, cutaneous adverse drug reactions that are rare but life threatening. Genetic…”
Get full text

Lack of ethnic differences of moxifloxacin and metabolite pharmacokinetics in East Asian men by Kaneko, M., Aoyama, T., Ishida, Y., Miyamoto, A., Saito, Y., Tohkin, M., Kawai, S., Matsumoto, Y.

“…This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2…”
Get full text

RACIAL VARIABILITY IN HAPLOTYPE FREQUENCIES OF UGT1A1 AND GLUCURONIDATION ACTIVITY OF A NOVEL SINGLE NUCLEOTIDE POLYMORPHISM 686C> T (P229L) FOUND IN AN AFRICAN-AMERICAN by KANIWA, Nahoko, KUROSE, Kouichi, JINNO, Hideto, TANAKA-KAGAWA, Toshiko, SAITO, Yoshiro, SAEKI, Mayumi, SAWADA, Jun-Ichi, TOHKIN, Masahiro, HASEGAWA, Ryuichi

“…Ethnic differences in genetic polymorphisms in UDP-glucuronosyltransferase 1A1 ( UGT1A1 ) were investigated among African-Americans, Caucasians, and Japanese…”
Get full text

Development of a detection algorithm for statin-induced myopathy using electronic medical records by Sai, K., Hanatani, T., Azuma, Y., Segawa, K., Tohkin, M., Omatsu, H., Makimoto, H., Hirai, M., Saito, Y.

“…Summary What is known and Objective Demonstration of the utility of electronic medical records (EMRs) for pharmacovigilance (PV) has been highly anticipated…”
Get full text

An algorithm for the identification of heparin-induced thrombocytopenia using a medical information database by Hanatani, T., Sai, K., Tohkin, M., Segawa, K., Kimura, M., Hori, K., Kawakami, J., Saito, Y.

“…Summary What is known and objective Using effective algorithms for extracting relevant drug and patient information from electronic medical information data…”
Get full text

Evaluation of two Japanese regulatory actions using medical information databases: a 'Dear Doctor' letter to restrict oseltamivir use in teenagers, and label change caution against co-administration of omeprazole with clopidogrel by Hanatani, T., Sai, K., Tohkin, M., Segawa, K., Antoku, Y., Nakashima, N., Yokoi, H., Ohe, K., Kimura, M., Hori, K., Kawakami, J., Saito, Y.

“…Summary What is known and objective The implementation of appropriate epidemiological methodology using medical information databases (MIDs) to evaluate the…”
Get full text

Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site by TOHKIN, M, KISHINO, J, ISHIZAKI, J, ARITA, H

“…Previously, we have reported a novel proliferative action of pancreatic group I phospholipase A2 (PLA2-I) via a specific binding site in Swiss 3T3 fibroblasts,…”
Get full text

Androgens directly stimulate mineralization and increase androgen receptors in human osteoblast-like osteosarcoma cells by Takeuchi, M, Kakushi, H, Tohkin, M

“…5 alpha-Dihydrotestosterone (DHT), an active form of testosterone, was shown to stimulate the mineralization of osteoblasts in a time- and dose-dependent…”
Get more information

PS-06-005 The mechanisms of erectile dysfunction after administration of anticancer agents in rats by Kataoka, T., Sanagawa, A., Suzuki, J., Muto, T., Kawade, Y., Hotta, Y., Maeda, Y., Tohkin, M., Kimura, K.

Get full text

PO-01-040 Influence of anticancer agents on erectile function: A study of erectile responses to anticancer agents in rats after analysis of FDA adverse event reporting system by Kataoka, T., Sanagawa, A., Suzuki, J., Muto, T., Hotta, Y., Kawade, Y., Maeda, Y., Tohkin, M., Kimura, K.

Get full text

Chemotactic Peptide Receptor-supported ADP-Ribosylation of a Pertussis Toxin Substrate GTP-binding Protein by Cholera Toxin in Neutrophil-type HL-60 Cells by Iiri, T, Tohkin, M, Morishima, N, Ohoka, Y, Ui, M, Katada, T

“…A 40-kDa protein, in addition to the α-subunits of Gs (a GTP-binding protein involved in adenylate cyclase stimulation), was [32P]ADP-ribosylated by cholera…”
Get full text

Okadaic acid potentiates 3-methylcholanthrene-induced CYP2A8 gene expression in primary cultures of Syrian hamster hepatocytes: possible involvement of activator protein-1 by Tohkin, M, Kurose, K, Fukuhara, M

“…In Syrian hamster liver, treatment with 3-methylcholanthrene (3-MC) markedly induces an isozyme of cytochrome P450 (CYP), CYP2A8. To elucidate the mechanism of…”
Get more information

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis by Sinal, Christopher J, Tohkin, Masahiro, Miyata, Masaaki, Ward, Jerrold M, Lambert, Gilles, Gonzalez, Frank J

“…Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR/BAR null mice were…”
Get full text

Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver by Sato, Shoko, Shirakawa, Hitoshi, Tomita, Shuhei, Ohsaki, Yusuke, Haketa, Keiichi, Tooi, Osamu, Santo, Noriaki, Tohkin, Masahiro, Furukawa, Yuji, Gonzalez, Frank J., Komai, Michio

“…2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is a common environmental contaminant. TCDD binds and activates the transcription factor aryl hydrocarbon receptor…”
Get full text

Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes by Kiso, Y, Tohkin, M, Hikino, H

Get more information

Hepatitis B infection reported with cancer chemotherapy: analyzing the US FDA Adverse Event Reporting System by Sanagawa, Akimasa, Hotta, Yuji, Kataoka, Tomoya, Maeda, Yasuhiro, Kondo, Masahiro, Kawade, Yoshihiro, Ogawa, Yoshihiro, Nishikawa, Ryohei, Tohkin, Masahiro, Kimura, Kazunori

“…We conducted data mining using the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database on spontaneously reported adverse…”
Get full text

Mechanism of antihepatotoxic activity of glycyrrhizin. I: Effect on free radical generation and lipid peroxidation by Kiso, Y, Tohkin, M, Hikino, H, Hattori, M, Sakamoto, T, Namba, T

Get more information

Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation by Sinal, Christopher J., Miyata, Masaaki, Tohkin, Masahiro, Nagata, Kiyoshi, Bend, John R., Gonzalez, Frank J.

“…Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can…”
Get full text

Mechanism of antihepatotoxic activity of atractylon, I: Effect on free radical generation and lipid peroxidation by Kiso, Y, Tohkin, M, Hikino, H

Get more information