Search Results - "Toh, McKenzi S"

Harnessing type I CRISPR–Cas systems for genome engineering in human cells by Cameron, Peter, Coons, Mary M., Klompe, Sanne E., Lied, Alexandra M., Smith, Stephen C., Vidal, Bastien, Donohoue, Paul D., Rotstein, Tomer, Kohrs, Bryan W., Nyer, David B., Kennedy, Rachel, Banh, Lynda M., Williams, Carolyn, Toh, Mckenzi S., Irby, Matthew J., Edwards, Leslie S., Lin, Chun-Han, Owen, Arthur L. G., Künne, Tim, van der Oost, John, Brouns, Stan J. J., Slorach, Euan M., Fuller, Chris K., Gradia, Scott, Kanner, Steven B., May, Andrew P., Sternberg, Samuel H.

“…Type I CRISPR–Cas systems are the most abundant adaptive immune systems in bacteria and archaea 1 , 2 . Target interference relies on a multi-subunit,…”
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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells by Donohoue, Paul D., Pacesa, Martin, Lau, Elaine, Vidal, Bastien, Irby, Matthew J., Nyer, David B., Rotstein, Tomer, Banh, Lynda, Toh, Mckenzi S., Gibson, Jason, Kohrs, Bryan, Baek, Kevin, Owen, Arthur L.G., Slorach, Euan M., van Overbeek, Megan, Fuller, Christopher K., May, Andrew P., Jinek, Martin, Cameron, Peter

“…The off-target activity of the CRISPR-associated nuclease Cas9 is a potential concern for therapeutic genome editing applications. Although high-fidelity Cas9…”
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Highly Specific Cas9 and Cas12a Engineering of Human T Cells for Generation of Novel Allogeneic Cell Therapies by Donohoue, Paul, Pacesa, Martin, Lau, Elaine, Vidal, Bastien, Irby, Matthew J, Nyer, David B, Rotstein, Tomer, Loncaric, Mikey, Ciminelli, Emma, Mause, Erica Vander, Munoz, Tony, Banh, Lynda, Toh, McKenzi S, Churchward, Glen, Gonzalez, Rachel, Gibson, Jason, Kohrs, Bryan, Baek, Kevin, Owen, Arthur L.G., Slorach, Euan M, van Overbeek, Megan, May, Andrew P, Garner, Elizabeth, Jinek, Martin, Cameron, Peter

“…CRISPR-based genome editing of primary human T cells has the potential to revolutionize disease-modifying therapies. However, substantial improvements in…”
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