Search Results - "Toh, Kazuko"

Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium by Gonzalez-Carter, Daniel, Liu, Xueying, Tockary, Theofilus A., Dirisala, Anjaneyulu, Toh, Kazuko, Anraku, Yasutaka, Kataoka, Kazunori

“…Current strategies to direct therapy-loaded nanoparticles to the brain rely on functionalizing nanoparticles with ligands which bind target proteins associated…”
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Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain by Abbasi, Saed, Uchida, Satoshi, Toh, Kazuko, Tockary, Theofilus A., Dirisala, Anjaneyulu, Hayashi, Kotaro, Fukushima, Shigeto, Kataoka, Kazunori

“…Genome editing using CRISPR/Cas9 has attracted considerable attention for the treatment of genetic disorders and viral infections. Co-delivery of Cas9 mRNA and…”
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Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier by Miura, Yutaka, Takenaka, Tomoya, Toh, Kazuko, Wu, Shourong, Nishihara, Hiroshi, Kano, Mitsunobu R, Ino, Yasushi, Nomoto, Takahiro, Matsumoto, Yu, Koyama, Hiroyuki, Cabral, Horacio, Nishiyama, Nobuhiro, Kataoka, Kazunori

“…Ligand-mediated drug delivery systems have enormous potential for improving the efficacy of cancer treatment. In particular, Arg-Gly-Asp peptides are promising…”
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Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors by Anraku, Yasutaka, Kishimura, Akihiro, Kamiya, Mako, Tanaka, Sayaka, Nomoto, Takahiro, Toh, Kazuko, Matsumoto, Yu, Fukushima, Shigeto, Sueyoshi, Daiki, Kano, Mitsunobu R., Urano, Yasuteru, Nishiyama, Nobuhiro, Kataoka, Kazunori

“…The design and construction of nanoreactors are important for biomedical applications of enzymes, but lipid‐ and polymeric‐vesicle‐based nanoreactors have some…”
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In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers by Watanabe, Sumiyo, Hayashi, Kotaro, Toh, Kazuko, Kim, Hyun Jin, Liu, Xueying, Chaya, Hiroyuki, Fukushima, Shigeto, Katsushima, Keisuke, Kondo, Yutaka, Uchida, Satoshi, Ogura, Satomi, Nomoto, Takahiro, Takemoto, Hiroyasu, Cabral, Horacio, Kinoh, Hiroaki, Tanaka, Hiroyoshi Y., Kano, Mitsunobu R., Matsumoto, Yu, Fukuhara, Hiroshi, Uchida, Shunya, Nangaku, Masaomi, Osada, Kensuke, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori

“…Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many…”
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Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors by Suzuki, Kazumi, Miura, Yutaka, Mochida, Yuki, Miyazaki, Takuya, Toh, Kazuko, Anraku, Yasutaka, Melo, Vinicio, Liu, Xueying, Ishii, Takehiko, Nagano, Osamu, Saya, Hideyuki, Cabral, Horacio, Kataoka, Kazunori

“…Nanomedicine modification with ligands directed to receptors on tumor blood vessels has the potential for selectively enhancing nanomedicine accumulation in…”
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Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma by Quader, Sabina, Liu, Xueying, Toh, Kazuko, Su, Yu-Lin, Maity, Amit Ranjan, Tao, Anqi, Paraiso, West Kristian D., Mochida, Yuki, Kinoh, Hiroaki, Cabral, Horacio, Kataoka, Kazunori

“…The crucial balance of stability in blood-circulation and tumor-specific delivery has been suggested as one of the challenges for effective bench-to-bedside…”
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Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles by Yi, Yu, Kim, Hyun Jin, Mi, Peng, Zheng, Meng, Takemoto, Hiroyasu, Toh, Kazuko, Kim, Beob Soo, Hayashi, Kotaro, Naito, Mitsuru, Matsumoto, Yu, Miyata, Kanjiro, Kataoka, Kazunori

“…For systemic delivery of small interfering RNA (siRNA) to solid tumors, we developed an actively-targeted unimer polyion complex-assembled gold nanoparticle…”
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Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment by Martin, John D, Panagi, Myrofora, Wang, Chenyu, Khan, Thahomina T, Martin, Margaret R, Voutouri, Chrysovalantis, Toh, Kazuko, Papageorgis, Panagiotis, Mpekris, Fotios, Polydorou, Christiana, Ishii, Genichiro, Takahashi, Shinichiro, Gotohda, Naoto, Suzuki, Toshiyuki, Wilhelm, Matthew E, Melo, Vinicio Alejandro, Quader, Sabina, Norimatsu, Jumpei, Lanning, Ryan M, Kojima, Motohiro, Stuber, Matthew David, Stylianopoulos, Triantafyllos, Kataoka, Kazunori, Cabral, Horacio

“…Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various…”
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Enzymatically Transformable Polymersome‐Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer by Li, Junjie, Ge, Zhishen, Toh, Kazuko, Liu, Xueying, Dirisala, Anjaneyulu, Ke, Wendong, Wen, Panyue, Zhou, Hang, Wang, Zheng, Xiao, Shiyan, Van Guyse, Joachim F. R., Tockary, Theofilus A., Xie, Jinbing, Gonzalez‐Carter, Daniel, Kinoh, Hiroaki, Uchida, Satoshi, Anraku, Yasutaka, Kataoka, Kazunori

“…Prevention of metastatic and local‐regional recurrence of cancer after surgery remains difficult. Targeting postsurgical premetastatic niche and microresiduals…”
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Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers by Cabral, Horacio, Makino, Jun, Matsumoto, Yu, Mi, Peng, Wu, Hailiang, Nomoto, Takahiro, Toh, Kazuko, Yamada, Naoki, Higuchi, Yuriko, Konishi, Satoshi, Kano, Mitsunobu R, Nishihara, Hiroshi, Miura, Yutaka, Nishiyama, Nobuhiro, Kataoka, Kazunori

“…Occult nodal metastases increase the risk of cancer recurrence, demoting prognosis and quality of life of patients. While targeted drug delivery by using…”
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Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors by Oe, Yusuke, Christie, R. James, Naito, Mitsuru, Low, Stewart A, Fukushima, Shigeto, Toh, Kazuko, Miura, Yutaka, Matsumoto, Yu, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori

“…Abstract For small interfering RNA (siRNA)-based cancer therapies, we report an actively-targeted and stabilized polyion complex micelle designed to improve…”
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Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(L-lysine) block copolymers as systemic gene delivery carrier by Takeda, Kaori M, Yamasaki, Yuichi, Dirisala, Anjaneyulu, Ikeda, Sorato, Tockary, Theofilus A, Toh, Kazuko, Osada, Kensuke, Kataoka, Kazunori

“…Abstract Structural stability of polyplex micelles (PMs), prepared from plasmid DNA (pDNA) and poly(ethylene glycol)- b -poly(L-lysine) block catiomer…”
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Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation by Inoue, Yuta, Matsumoto, Yu, Toh, Kazuko, Miyano, Kazuki, Cabral, Horacio, Igarashi, Kazunori, Iwasaki, Shinichi, Kataoka, Kazunori, Yamasoba, Tatsuya

“…Selectively delivering anticancer drugs to solid tumors while avoiding their accumulation in healthy tissues is a major goal in polymeric micelle research. We…”
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Light-Induced Cytosolic Activation of Reduction-Sensitive Camptothecin-Loaded Polymeric Micelles for Spatiotemporally Controlled in Vivo Chemotherapy by Yen, Hung-Chi, Cabral, Horacio, Mi, Peng, Toh, Kazuko, Matsumoto, Yu, Liu, Xueying, Koori, Hiroshi, Kim, Ahram, Miyazaki, Kozo, Miura, Yutaka, Nishiyama, Nobuhiro, Kataoka, Kazunori

“…Nanomedicines capable of smart operation at the targeted site have the potential to achieve the utmost therapeutic benefits. Providing nanomedicines that…”
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Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)‑b‑poly(l‑lysine) by Chaya, Hiroyuki, Naito, Mitsuru, Cho, Masaru, Toh, Kazuko, Hayashi, Kotaro, Fukushima, Shigeto, Yamasaki, Yuichi, Kataoka, Kazunori, Miyata, Kanjiro

“…To stabilize small interfering RNA (siRNA) in the bloodstream for systemic RNAi therapeutics, we previously fabricated ultrasmall siRNA nanocarriers that were…”
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Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine) by Naito, Mitsuru, Chaya, Hiroyuki, Toh, Kazuko, Kim, Beob Soo, Hayashi, Kotaro, Fukushima, Shigeto, Nagata, Tetsuya, Yokota, Takanori, Kataoka, Kazunori, Miyata, Kanjiro

“…Downsizing nanocarriers is a promising strategy for systemically targeting fibrotic cancers, such as pancreatic cancer, owing to enhanced tissue permeability…”
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Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting by Chen, Qixian, Osada, Kensuke, Ge, Zhishen, Uchida, Satoshi, Tockary, Theofilus A, Dirisala, Anjaneyulu, Matsui, Akitsugu, Toh, Kazuko, Takeda, Kaori M, Liu, Xueying, Nomoto, Takahiro, Ishii, Tekihiko, Oba, Makoto, Matsumoto, Yu, Kataoka, Kazunori

“…Abstract Both efficiency and safety profiles are crucial for promotion of gene delivery systems towards practical applications. A promising template system was…”
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Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum by Nuhn, Lutz, Gietzen, Sabine, Mohr, Kristin, Fischer, Karl, Toh, Kazuko, Miyata, Kanjiro, Matsumoto, Yu, Kataoka, Kazunori, Schmidt, Manfred, Zentel, Rudolf

“…For systemic siRNA delivery applications, well-defined drug carriers are required that guarantee stability for both carrier and cargo. Among various concepts…”
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Kinetic Analysis of Superoxide Anion Radical-Scavenging and Hydroxyl Radical-Scavenging Activities of Platinum Nanoparticles by Hamasaki, Takeki, Kashiwagi, Taichi, Imada, Toshifumi, Nakamichi, Noboru, Aramaki, Shinsuke, Toh, Kazuko, Morisawa, Shinkatsu, Shimakoshi, Hisashi, Hisaeda, Yoshio, Shirahata, Sanetaka

“…There are few reports on the physiological effects of metal nanoparticles (nps), especially with respect to their functions as scavengers for superoxide anion…”
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