Search Results - "Tognon, C E"

Recurrent cyclin D2 mutations in myeloid neoplasms by Khanna, V, Eide, C A, Tognon, C E, Maxson, J E, Wilmot, B, Bottomly, D, McWeeney, S, Edwards V, D K, Druker, B J, Tyner, J W

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A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation by Tognon, C E, Martin, M J, Moradian, A, Trigo, G, Rotblat, B, Cheng, S-W G, Pollard, M, Uy, E, Chow, C, Carboni, J M, Gottardis, M M, Pollak, M, Morin, G B, Sorensen, P H B

“…ETV6-NTRK3 (EN), a chimeric tyrosine kinase generated by t(12;15) translocations, is a dominantly acting oncoprotein in diverse tumor types. We previously…”
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Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia by Agarwal, A, MacKenzie, R J, Eide, C A, Davare, M A, Watanabe-Smith, K, Tognon, C E, Mongoue-Tchokote, S, Park, B, Braziel, R M, Tyner, J W, Druker, B J

“…To understand the role of cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis, we designed a functional RNA interference (RNAi)…”
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Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain by Tognon, Cristina E., Kirk, Heather E., Passmore, Lori A., Whitehead, Ian P., Der, Channing J., Kay, Robert J.

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ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors via Activation of AP1 Complex by Li, Zhe, Tognon, Cristina E., Godinho, Frank J., Yasaitis, Laura, Hock, Hanno, Herschkowitz, Jason I., Lannon, Chris L., Cho, Eunah, Kim, Seong-Jin, Bronson, Roderick T., Perou, Charles M., Sorensen, Poul H., Orkin, Stuart H.

“…To better understand the cellular origin of breast cancer, we developed a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein,…”
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Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia by White, Brian S., Khan, Suleiman A., Mason, Mike J., Ammad-ud-din, Muhammad, Potdar, Swapnil, Malani, Disha, Kuusanmäki, Heikki, Druker, Brian J., Heckman, Caroline, Kallioniemi, Olli, Kurtz, Stephen E., Porkka, Kimmo, Tognon, Cristina E., Tyner, Jeffrey W., Aittokallio, Tero, Wennerberg, Krister, Guinney, Justin

“…The FDA recently approved eight targeted therapies for acute myeloid leukemia (AML), including the BCL-2 inhibitor venetoclax. Maximizing efficacy of these…”
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A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation by Lannon, Chris L, Martin, Matthew J, Tognon, Cristina E, Jin, Wook, Kim, Seong-Jin, Sorensen, Poul H B

“…Receptor tyrosine kinases are integral components of cellular signaling pathways and are frequently deregulated in malignancies. The NTRK family of…”
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ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation by MORRISON, Kevin B, TOGNON, Cristina E, GARNETT, Mathew J, DEAL, Cheri, SORENSEN, Poul H. B

“…Congenital fibrosarcoma (CFS) and cellular mesoblastic nephroma (CMN) are pediatric spindle cell malignancies that share two specific cytogenetic…”
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Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity by Tognon, Cristina E., Mackereth, Cameron D., Somasiri, Aruna M., McIntosh, Lawrence P., Sorensen, Poul H. B.

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Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni by Siddiqui, A A, Zhou, Y, Podesta, R B, Karcz, S R, Tognon, C E, Strejan, G H, Dekaban, G A, Clarke, M W

“…Calcium-dependent, neutral cysteine-proteases (calpain) were purified from human blood flukes, Schistosoma mansoni. The electrophoretic mobilities, Western…”
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