Search Results - "Togher, Susan"

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex by Balasubramani, Anand, Larjo, Antti, Bassein, Jed A., Chang, Xing, Hastie, Ryan B., Togher, Susan M., Lähdesmäki, Harri, Rao, Anjana

“…ASXL1 is the obligate regulatory subunit of a deubiquitinase complex whose catalytic subunit is BAP1. Heterozygous mutations of ASXL1 that result in premature…”
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TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells by Tsagaratou, Ageliki, González-Avalos, Edahí, Rautio, Sini, Scott-Browne, James P, Togher, Susan, Pastor, William A, Rothenberg, Ellen V, Chavez, Lukas, Lähdesmäki, Harri, Rao, Anjana

“…TET proteins regulate 5-methylcytosine epigenetic marks, and thereby regulate chromatin accessibility. Rao and colleagues show that the combined loss of TET2…”
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Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors by Bandukwala, Hozefa S, Gagnon, John, Togher, Susan, Greenbaum, Jason A, Lamperti, Edward D, Parr, Nigel J, Molesworth, Amy M. H, Smithers, Nicholas, Lee, Kevin, Witherington, Jason, Tough, David F, Prinjha, Rab K, Peters, Bjoern, Rao, Anjana

“…Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone…”
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Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation by Shaked, Iftach, Hanna, Richard N, Shaked, Helena, Chodaczek, Grzegorz, Nowyhed, Heba N, Tweet, George, Tacke, Robert, Basat, Alp Bugra, Mikulski, Zbigniew, Togher, Susan, Miller, Jacqueline, Blatchley, Amy, Salek-Ardakani, Shahram, Darvas, Martin, Kaikkonen, Minna U, Thomas, Graham D, Lai-Wing-Sun, Sonia, Rezk, Ayman, Bar-Or, Amit, Glass, Christopher K, Bandukwala, Hozefa, Hedrick, Catherine C

“…Stress can induce expression of norepinephrine, which can enhance neuroinflammation. Shaked, Hedrick and colleagues show that the transcriptional repressor…”
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TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities by Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino, Monticelli, Silvia

“…Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2…”
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Immune Adjuvant Efficacy of CpG Oligonucleotide in Cancer Treatment Is Founded Specifically upon TLR9 Function in Plasmacytoid Dendritic Cells by NIERKENS, Stefan, DEN BROK, Martijn H, ADEMA, Gosse J, JANSSEN, Edith M, GARCIA, Zacharias, TOGHER, Susan, WAGENAARS, Jori, WASSINK, Melissa, BOON, Louis, RUERS, Theo J, FIGDOR, Carl G, SCHOENBERGER, Stephen P

“…The differences in function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs (pDC) not only point to specialized…”
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TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities by Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino, Monticelli, Silvia

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Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells by Feau, Sonia, Arens, Ramon, Togher, Susan, Schoenberger, Stephen P

“…The generation of CD8 + T cell memory requires both CD4 + T cells and dendritic cells. Schoenberger et al . show that autocrine production of interleukin 2 by…”
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Exhaustion-associated regulatory regions in CD8⁺ tumor-infiltrating T cells by Mognol, Giuliana P., Spreafico, Roberto, Wong, Victor, Scott-Browne, James P., Togher, Susan, Hoffmann, Alexander, Hogan, Patrick G., Rao, Anjana, Trifari, Sara

“…T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections…”
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The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells by Martinez, Gustavo J, Pereira, Renata M, Äijö, Tarmo, Kim, Edward Y, Marangoni, Francesco, Pipkin, Matthew E, Togher, Susan, Heissmeyer, Vigo, Zhang, Yi Chen, Crotty, Shane, Lamperti, Edward D, Ansel, K Mark, Mempel, Thorsten R, Lähdesmäki, Harri, Hogan, Patrick G, Rao, Anjana

“…During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the…”
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Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection by Martinez, Gustavo J, Hu, Joyce K, Pereira, Renata M, Crampton, Jordan S, Togher, Susan, Bild, Nicholas, Crotty, Shane, Rao, Anjana

“…Follicular CD4(+) Th (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of…”
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FoxO3 is a negative regulator of primary CD8+ T‐cell expansion but not of memory formation by Togher, Susan, Larange, Alexandre, Schoenberger, Stephen P, Feau, Sonia

“…The generation of CD8+ T cells by vaccination represents an important goal for protective immunity to infectious pathogens. It is thus of utmost importance to…”
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NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection by Martinez, Gustavo J, Hu, Joyce, Pereira, Renata, Crampton, Jordan, Togher, Susan, Bild, Nicholas, Crotty, Shane, Rao, Anjana

“…Abstract Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the…”
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TET2 and 3 proteins control iNKT cell lineage specification and TCR mediated expansion by Tsagaratou, Ageliki, Avalos, Edahi Gonzalez, Rautio, Sini, Browne, James Scott, Togher, Susan, Pastor, William, Rothenberg, Ellen V., Lahdesmaki, Harri, Rao, Anjana

“…Abstract TET proteins are 2-oxoglutarate- and Fe(II) dependent dioxygenases that catalyze the hydroxylation of 5-methylcytosine (5mC) to…”
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Exhaustion-associated regulatory regions in CD8^sup +^ tumor-infiltrating T cells by Mognol, Giuliana P, Spreafico, Roberto, Wong, Victor, Scott-Browne, James P, Togher, Susan, Hoffmann, Alexander, Hogan, Patrick G, Rao, Anjana, Trifari, Sara

“…T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections…”
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NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection by Martinez, Gustavo J., Hu, Joyce K., Pereira, Renata M., Crampton, Jordan S., Togher, Susan, Bild, Nicholas, Crotty, Shane, Rao, Anjana

“…Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of…”
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Exhaustion-associated regulatory regions in CD8 super( +) tumor-infiltrating T cells by Mognol, Giuliana P, Spreafico, Roberto, Wong, Victor, Scott-Browne, James P, Togher, Susan, Hoffmann, Alexander, Hogan, Patrick G, Rao, Anjana, Trifari, Sara

“…T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections…”
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Autocrine IL-2 is required for secondary population expansion of [CD8.sup.+] memory T cells by Feau, Sonia, Arens, Ramon, Togher, Susan, Schoenberger, Stephen P

“…Two competing theories have been put forward to explain the role of [CD4.sup.+] T cells in priming [CD8.sup.+] memory T cells: one proposes paracrine secretion…”
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Autocrine IL-2 is required for secondary population expansion of CD8 super(+) memory T cells by Feau, Sonia, Arens, Ramon, Togher, Susan, Schoenberger, Stephen P

“…Two competing theories have been put forward to explain the role of CD4 super(+) T cells in priming CD8 super(+) memory T cells: one proposes paracrine…”
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The orphan nuclear receptor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation by Shaked, Iftach, Hanna, Richard N., Shaked, Helena, Chodaczek, Grzegorz, Nowyhed, Heba N., Tweet, George, Tacke, Robert, Basat, Alp Bugra, Mikulski, Zbigniew, Togher, Susan, Miller, Jacqueline, Blatchley, Amy, Salek-Ardakani, Shahram, Darvas, Martin, Kaikkonen, Minna U., Thomas, Graham, Lai-Wing-Sun, Sonia, Rezk, Ayman, Bar-Or, Amit, Glass, Christopher K., Bandukwala, Hozefa, Hedrick, Catherine C.

“…Molecular mechanisms linking the sympathetic stress response and inflammation remain enigmatic. Here we demonstrate that the transcription factor Nr4a1…”
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