Search Results - "Togari, Akifumi"

Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes by Fujihara, Yuko, Kondo, Hisataka, Noguchi, Toshihide, Togari, Akifumi

“…Abstract Circadian rhythms are prevalent in bone metabolism. However, the molecular mechanisms involved are poorly understood. Recently, we suggested that…”
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α1-Adrenergic Receptor Signaling in Osteoblasts Regulates Clock Genes and Bone Morphogenetic Protein 4 Expression through Up-regulation of the Transcriptional Factor Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding Protein 4 (E4BP4) by Hirai, Takao, Tanaka, Kenjiro, Togari, Akifumi

“…Several studies have demonstrated that the α1-adrenergic receptor (AR) plays an important role in regulating cell growth and function in osteoblasts. However,…”
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Adrenergic regulation of bone metabolism: Possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells by Togari, Akifumi

“…It has been demonstrated that human osteoblastic as well as osteoclastic cells are equipped with adrenergic receptors and neuropeptide receptors and that they…”
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Guanabenz inhibits alveolar bone resorption in a rat model of periodontitis by Muramatsu, Ryujiro, Sato, Takuma, Hamamura, Kazunori, Miyazawa, Ken, Takeguchi, Atsushi, Tabuchi, Masako, Togari, Akifumi, Goto, Shigemi

“…Increase of sympathetic activity has been known to exacerbate osteoporosis through promotion of bone resorption. However, it is largely unknown about…”
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Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts by Tanaka, Kenjiro, Kondo, Hisataka, Hamamura, Kazunori, Togari, Akifumi

“…Opioid receptor blockers such as naloxone and naltrexone have been suggested to have a bone mass-increasing effect. However, the mechanisms at play have not…”
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Pharmacological Topics of Bone Metabolism: The Physiological Function of the Sympathetic Nervous System in Modulating Bone Resorption by Togari, Akifumi, Arai, Michitsugu

“…The vertebrate skeleton is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent studies…”
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Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system by Kodama, Daisuke, Hirai, Takao, Kondo, Hisataka, Hamamura, Kazunori, Togari, Akifumi

“…Recent studies have revealed that the sensory nervous system is involved in bone metabolism. However, the mechanism of communication between neurons and…”
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Effects of a β2-adrenergic receptor blocker on experimental periodontitis in spontaneously hypertensive rats by Takeguchi, Atsushi, Miyazawa, Ken, Sato, Takuma, Tabuchi, Masako, Muramatsu, Ryujiro, Maeda, Hatsuhiko, Togari, Akifumi, Goto, Shigemi

“…Recent studies have reported a relationship between periodontal disease and hypertension, and previous evidence suggests that the sympathetic nervous system…”
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Effects of propranolol on bone metabolism in spontaneously hypertensive rats by Sato, Takuma, Arai, Michitsugu, Goto, Shigemi, Togari, Akifumi

“…The effects of propranolol (PRO), a nonselective beta-adrenergic receptor (beta-AR) antagonist with membrane-stabilizing action on bone metabolism, were…”
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The Physiological Function of the Sympathetic Nervous System in Modulating Bone Resorption by Akifumi Togari, Michitsugu Arai

“…Abstract. The vertebrate skeleton is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling…”
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Modulation of osteoblast differentiation and bone mass by 5-HT2A receptor signaling in mice by Tanaka, Kenjiro, Hirai, Takao, Ishibashi, Yukiko, Izumo, Nobuo, Togari, Akifumi

“…Recent studies reported that serotonin (5-hydroxytryptamine, 5-HT) may be an endogenous paracrine and/or autocrine factor that is used for intercellular…”
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Store-operated calcium entry induced by activation of Gq-coupled alpha1B adrenergic receptor in human osteoblast by Kodama, Daisuke, Togari, Akifumi

“…•Noradrenaline-induced Ca2+ response was abolished by removal of extracellular Ca2+.•Neither voltage-dependent Ca2+ channel nor Na+/Ca2+ exchanger was…”
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Attenuation of Bone Formation through a Decrease in Osteoblasts in Mutant Mice Lacking the GM2/GD2 Synthase Gene by Sasaki, Eri, Hamamura, Kazunori, Mishima, Yoshitaka, Furukawa, Koichi, Nagao, Mayu, Kato, Hanami, Hamajima, Kosuke, Sato, Takuma, Miyazawa, Ken, Goto, Shigemi, Togari, Akifumi

“…The ganglioside GD1a has been reported to promote the differentiation of mesenchymal stem cells to osteoblasts in cell culture systems. However, the…”
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Experimental tooth movement-induced osteoclast activation is regulated by sympathetic signaling by Kondo, Mayo, Kondo, Hisataka, Miyazawa, Ken, Goto, Shigemi, Togari, Akifumi

“…Abstract Experimental tooth movement (ETM) changes the distribution of sensory nerve fibers in periodontal ligament and the bone architecture through the…”
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Co-cultured spheroids of human periodontal ligament mesenchymal stem cells and vascular endothelial cells enhance periodontal tissue regeneration by Sano, Kotaro, Usui, Michihiko, Moritani, Yuki, Nakazawa, Kohji, Hanatani, Tomoya, Kondo, Hisataka, Nakatomi, Mitsushiro, Onizuka, Satoru, Iwata, Takanori, Sato, Tsuyoshi, Togari, Akifumi, Ariyoshi, Wataru, Nishihara, Tatsuji, Nakashima, Keisuke

“…Human periodontal ligament mesenchymal stem cells (hPDLMSCs) have been known that they play important roles in homeostasis and regeneration of periodontal…”
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Activation of Caspases Is Required for Osteoblastic Differentiation by Mogi, Makio, Togari, Akifumi

“…Previous studies have shown that mouse osteoblastic MC3T3-E1 cells undergo apoptosis when exposed to a mixture of proinflammatory cytokines. Bone morphogenetic…”
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Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging by Yo, Shoyoku, Hamamura, Kazunori, Mishima, Yoshitaka, Hamajima, Kosuke, Mori, Hironori, Furukawa, Koichi, Kondo, Hisataka, Tanaka, Kenjiro, Sato, Takuma, Miyazawa, Ken, Goto, Shigemi, Togari, Akifumi

“…Gangliosides are widely expressed in almost all tissues and cells and are also considered to be essential in the development and maintenance of various organs…”
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Contribution of Glucosylceramide Synthase to the Proliferation of Mouse Osteoblasts by Mishima, Yoshitaka, Hamamura, Kazunori, Kato, Hanami, Furukawa, Koichi, Tashima, Yuko, Okajima, Tetsuya, Kondo, Hisataka, Sato, Takuma, Miyazawa, Ken, Goto, Shigemi, Togari, Akifumi

“…Glycosphingolipids are known to be involved in bone metabolism. However, their roles and regulatory mechanisms in osteoblast proliferation are largely unknown…”
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Involvement of TRP channels in the signal transduction of bradykinin in human osteoblasts by Suzuki, Yasuhiko, Kodama, Daisuke, Goto, Shigemi, Togari, Akifumi

“…► Ca2+-influx contributed to bradykinin-induced [Ca2+]i elevation in osteoblasts. ► Bradykinin activated store-operated Ca2+ channels via B2 receptor. ► TRPC1,…”
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Deletion of Gb3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease in Osteoblasts by Hamamura, Kazunori, Hamajima, Kosuke, Yo, Shoyoku, Mishima, Yoshitaka, Furukawa, Koichi, Uchikawa, Makoto, Kondo, Yuji, Mori, Hironori, Kondo, Hisataka, Tanaka, Kenjiro, Miyazawa, Ken, Goto, Shigemi, Togari, Akifumi

“…Glycosphingolipids are known to play a role in developing and maintaining the integrity of various organs and tissues. Among glycosphingolipids, there are…”
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