Search Results - "Tofilon, Philip J."

The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts by Timme, Cindy R, Rath, Barbara H, O'Neill, John W, Camphausen, Kevin, Tofilon, Philip J

“…Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of radiation-induced double strand…”
Get full text

A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma by Krauze, Andra V., MD, Myrehaug, Sten D., MD, Chang, Michael G., MD, Holdford, Diane J, Smith, Sharon, Shih, Joanna, MD, Tofilon, Philip J., PhD, Fine, Howard A., MD, Camphausen, Kevin, MD

“…Purpose Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to…”
Get full text

Inhibition of Histone Deacetylation: A Strategy for Tumor Radiosensitization by Camphausen, Kevin, Tofilon, Philip J

“…Recently, strategies to enhance tumor radiosensitivity have begun to focus on targeting the molecules and processes that regulate cellular radioresponse. A…”
Get full text

Astrocytes enhance the invasion potential of glioblastoma stem-like cells by Rath, Barbara H, Fair, Joshlean M, Jamal, Muhammad, Camphausen, Kevin, Tofilon, Philip J

“…Glioblastomas (GBMs) are characterized as highly invasive; the contribution of GBM stem-like cells (GSCs) to the invasive phenotype, however, has not been…”
Get full text

Targeting PRMT5 enhances the radiosensitivity of tumor cells grown in vitro and in vivo by Degorre, Charlotte, Lohard, Steven, Bobrek, Christina N., Rawal, Komal N., Kuhn, Skyler, Tofilon, Philip J.

“…PRMT5 is a widely expressed arginine methyltransferase that regulates processes involved in tumor cell proliferation and survival. In the study described here,…”
Get full text

MGMT inhibition regulates radioresponse in GBM, GSC, and melanoma by Yun, Hong Shik, Kramp, Tamalee R., Palanichamy, Kamalakannan, Tofilon, Philip J., Camphausen, Kevin

“…Radiotherapy is the standard treatment for glioblastoma (GBM), but the overall survival rate for radiotherapy treated GBM patients is poor. The use of adjuvant…”
Get full text

CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I by Lehman, Stacey L., Schwartz, Kayla R., Maheshwari, Shrankhla, Camphausen, Kevin, Tofilon, Philip J.

“…Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical…”
Get full text

CD133+ Glioblastoma Stem-like Cells are Radiosensitive with a Defective DNA Damage Response Compared with Established Cell Lines by MCCORD, Amy M, JAMAL, Muhammad, WILLIAMS, Eli S, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Purpose: CD133 + glioblastoma tumor stem-like cells (TSC) have been defined as radioresistant. However, although previously classified relative to CD133 −…”
Get full text

The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells by Jamal, Muhammad, Rath, Barbara H, Tsang, Patricia S, Camphausen, Kevin, Tofilon, Philip J

“…Abstract Brain tumor xenografts initiated from glioblastoma (GBM) CD133+ tumor stem-like cells (TSCs) are composed of TSC and non-TSC subpopulations,…”
Get full text

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration by Arscott, W. Tris, Tandle, Anita T, Zhao, Shuping, Shabason, Jacob E, Gordon, Ira K, Schlaff, Cody D, Zhang, Guofeng, Tofilon, Philip J, Camphausen, Kevin A

“…Abstract Exosomes are nanometer-sized lipid vesicles released ubiquitously by cells, which have been shown to have a normal physiological role, as well as…”
Get full text

Inhibition of Hsp90: A Multitarget Approach to Radiosensitization by CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Hsp90, the 90 kDa heat shock protein, is a highly expressed molecular chaperone that modulates the stability and/or transport of a diverse set of critical…”
Get full text

Translation Initiation Machinery as a Tumor Selective Target for Radiosensitization by Lehman, Stacey L., Wilson, Evan D., Camphausen, Kevin, Tofilon, Philip J.

“…Towards improving the efficacy of radiotherapy, one approach is to target the molecules and processes mediating cellular radioresponse. Along these lines,…”
Get full text

Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic by Shabason, Jacob E., Tofilon, Philip J., Camphausen, Kevin

“…Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumour. Patients afflicted with this disease unfortunately have a very poor…”
Get full text

Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro by McCord, Amy M, Jamal, Muhammad, Shankavaram, Uma T, Shankavarum, Uma T, Lang, Frederick F, Camphausen, Kevin, Tofilon, Philip J

“…In vitro investigations of tumor stem-like cells (TSC) isolated from human glioblastoma (GB) surgical specimens have been done primarily at an atmospheric…”
Get full text

Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells by Wahba, Amy, Rath, Barbara H, Bisht, Kheem, Camphausen, Kevin, Tofilon, Philip J

“…Changes in polysome-bound mRNA (translatome) are correlated closely with changes in the proteome in cells. Therefore, to better understand the processes…”
Get full text

Inhibition of Hsp90 compromises the DNA damage response to radiation by DOTE, Hideaki, BURGAN, William E, CAMPHAUSEN, Kevin, TOFILON, Philip J

“…Inhibitors of the molecular chaperone Hsp90 have been shown to enhance tumor cell radiosensitivity. To begin to address the mechanism responsible, we have…”
Get full text

Preclinical models in radiation oncology by Kahn, Jenna, Tofilon, Philip J, Camphausen, Kevin

“…As the incidence of cancer continues to rise, the use of radiotherapy has emerged as a leading treatment modality. Preclinical models in radiation oncology are…”
Get full text

Post-radiation increase in VEGF enhances glioma cell motility in vitro by Kil, Whoon Jong, Tofilon, Philip J, Camphausen, Kevin

“…Glioblastoma multiforme (GBM) is among the most lethal of all human tumors, with frequent local recurrences after radiation therapy (RT). The mechanism…”
Get full text

In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016 by RUSSO, Andrea L, KWON, Hyuk-Chan, CAMPHAUSEN, Kevin, BURGAN, William E, CARTER, Donna, BEAM, Katie, XU WEIZHENG, JIE ZHANG, SLUSHER, Barbara S, CHAKRAVARTI, Arnab, TOFILON, Philip J

“…Purpose: Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP inhibition has been shown to…”
Get full text

Molecular Targets for Tumor Radiosensitization by Tofilon, Philip J, Camphausen, Kevin

“…Biochemical reactions which make tumor cells more sensitive to radiation while ignoring normal cells are examined. It is noted that such a strategy to improve…”
Get full text