Search Results - "Toezser, J"

Comparative studies on retroviral proteases: substrate specificity by Tözsér, József

“…Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are…”
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Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency by Kapust, Rachel B., Tözsér, József, Fox, Jeffrey D., Anderson, D.Eric, Cherry, Scott, Copeland, Terry D., Waugh, David S.

“…Because of its stringent sequence specificity, the catalytic domain of the nuclear inclusion protease from tobacco etch virus (TEV) is a useful reagent for…”
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Urokinase-type plasminogen activator in rabbit tears. Comparison with human tears by Tözsér, J, Berta, A

“…Plasminogen activator activity was determined in stimulated normal rabbit tears, and was identified as being due to urokinase using specific antibodies. The…”
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Folded Monomer of HIV-1 Protease by Ishima, Rieko, Ghirlando, Rodolfo, Tözsér, József, Gronenborn, Angela M., Torchia, Dennis A., Louis, John M.

“…The mature human immunodeficiency virus type 1 protease rapidly folds into an enzymatically active stable dimer, exhibiting an intricate interplay between…”
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Narrow Substrate Specificity and Sensitivity toward Ligand-binding Site Mutations of Human T-cell Leukemia Virus Type 1 Protease by Kádas, János, Weber, Irene T., Bagossi, Péter, Miklóssy, Gabriella, Boross, Péter, Oroszlan, Stephen, Tözsér, József

“…Human T-cell leukemia virus type 1 (HTLV-1) is associated with a number of human diseases; therefore, its protease is a potential target for chemotherapy. To…”
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Improved purification protocol for wild-type and mutant human foamy virus proteases by Boross, Péter, Tözsér, József, Bagossi, Péter

“…Wild-type and an active site mutant (S25T) human foamy virus (HFV) proteases were expressed in fusion with maltose binding protein in Escherichia coli. The…”
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Stabilization from Autoproteolysis and Kinetic Characterization of the Human T-cell Leukemia Virus Type 1 Proteinase by Louis, John M., Oroszlan, Stephen, Tözsér, József

“…We have developed a system for expression and purification of wild-type human T-cell leukemia virus type 1 (HTLV-1) proteinase to attain sufficient quantities…”
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In Vitro Processing of HIV-1 Nucleocapsid Protein by the Viral Proteinase:  Effects of Amino Acid Substitutions at the Scissile Bond in the Proximal Zinc Finger Sequence by Tözsér, József, Shulenin, Sergey, Louis, John M, Copeland, Terry D, Oroszlan, Stephen

“…The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein flanked by Gag sequences (r-preNC) was expressed in Escherichia coli and purified. HIV-1…”
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Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins by Tözsér, József, Bláha, Ivo, Copeland, Terry D., Wondrak, Ewald M., Oroszlan, Stephen

“…The substrate specificity of the human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) proteinases was compared using oligopeptides corresponding to…”
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Effect of sequence polymorphism and drug resistance on two HIV‐1 Gag processing sites by Fehér, Anita, Weber, Irene T., Bagossi, Péter, Boross, Péter, Mahalingam, Bhuvaneshwari, Louis, John M., Copeland, Terry D., Torshin, Ivan Y., Harrison, Robert W., Tözsér, József

“…The HIV‐1 proteinase (PR) has proved to be a good target for antiretroviral therapy of AIDS, and various PR inhibitors are now in clinical use. However, there…”
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Change of amino acid profile in Charolais cows´colostrum and transient milk during the first week post partum by Zandoki, R, Csapo, J, Csapo-Kiss, Z, Tabori, I, Domokos, Z, Szuecs, E, Toezser, J

“…A herd of 37 Charolais cows was used to evaluate the changes in amino acids in colostrum and transient milk during the first week after parturition. Colostrum…”
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Temperament of Holstein Friesian cows in milking parlour and its relation to milk production by Andrea Szentléleki, Jeremy Hervé, Ferenc Pajor, Daniel Falta, János Tőzsér

“…The aim of this study was to evaluate the change of temperament of Holstein cows scored before and during milking during the entire lactation and to calculate…”
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Studies on the Symmetry and Sequence Context Dependence of the HIV-1 Proteinase Specificity by Tözsér, József, Bagossi, Péter, Weber, Irene T., Louis, John M., Copeland, Terry D., Oroszlan, Stephen

“…Two major types of cleavage sites with different sequence preferences have been proposed for the human immunodeficiency virus type 1 (HIV-1) proteinase. To…”
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Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1 by Briggs, C. J, Ott, D. E, Coren, L. V, Oroszlan, S, Tözsér, J

“…The presence of FK506-binding protein-12 was demonstrated in virions of HIV-1, although its concentration was lower than that of cyclophilin A. The effect of…”
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Comparison of the substrate specificity of the human T‐cell leukemia virus and human immunodeficiency virus proteinases by Tözsér, József, Zahuczky, Gábor, Bagossi, Péter, Louis, John M., Copeland, Terry D., Oroszlan, Stephen, Harrison, Robert W., Weber, Irene T.

“…Human T‐cell leukemia virus type‐1 (HTLV‐1) is associated with a number of human diseases. Based on the therapeutic success of human immunodeficiency virus…”
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Comparative Studies on the Substrate Specificity of Avian Myeloblastosis Virus Proteinase and Lentiviral Proteinases by Tözsér, J, Bagossi, P, Weber, I T, Copeland, T D, Oroszlan, S

“…The retroviral proteinase (PR) seems to play crucial roles in the viral life cycle, therefore it is an attractive target for chemotherapy. Previously we…”
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Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers by Bagossi, P, Cheng, Y S, Oroszlan, S, Tözsér, J

“…The specificity of linked homo- and heterodimeric HIV-1 and HIV-2 proteinases was characterized by using oligopeptide substrates. For two substrates the…”
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Effect of substrate residues on the P2′ preference of retroviral proteinases by Boross, Péter, Bagossi, Péter, Copeland, Terry D., Oroszlan, Stephen, Louis, John M., Tözsér, József

“…The substrate sequence requirements for preference toward P2′ Glu residue by human immunodeficiency virus type 1 (HIV‐1) proteinase were studied in both the…”
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Effect of cyclosporin A on the replication cycle of human immunodeficiency virus type 1 derived from H9 and Molt-4 producer cells by Briggs, Carlton J, Tozser, Jozsef, Oroszlan, Stephen

“…1 Laboratory of Molecular Virology and Carcinogenesis, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, MD…”
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Activity of linked HIV-1 proteinase dimers containing mutations in the active site region by Bagossi, Péter, Cheng, Yin-Shyun E., Oroszlan, Stephen, Tözsér, József

“…Mutations were introduced into the active site triplet (Asp–Thr–Gly) of one or both subunits of a linked dimer of human immunodeficiency virus type 1…”
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