Search Results - "Toes, Rene E"

From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis by Scherer, Hans Ulrich, van der Woude, Diane, Toes, Rene E. M.

“…The presence of disease-specific autoantibody responses and the efficacy of B cell-targeting therapies in rheumatoid arthritis (RA) indicate a pivotal role for…”
Get full text

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis by Trouw, Leendert A., Rispens, Theo, Toes, Rene E. M.

“…Key Points As well as citrullination, several other post-translational protein modifications are targeted by autoantibodies in rheumatoid arthritis (RA)…”
Get full text

The B cell response to citrullinated antigens in the development of rheumatoid arthritis by Scherer, Hans Ulrich, Huizinga, Tom W. J., Krönke, Gerhard, Schett, Georg, Toes, Rene E. M.

“…Key Points The anti-citrullinated protein antibody (ACPA) response dynamically evolves before the onset of rheumatoid arthritis (RA) HLA-shared epitope alleles…”
Get full text

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage by Shi, Jing, Knevel, Rachel, Suwannalai, Parawee, van der Linden, Michael P, Janssen, George M. C, van Veelen, Peter A, Levarht, Nivine E. W, van der Helm-van Mil, Annette H. M, Cerami, Anthony, Huizinga, Tom W. J, Toes, Rene E. M, Trouw, Leendert A

“…Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated…”
Get full text

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis by Rombouts, Yoann, Ewing, Ewoud, van de Stadt, Lotte A, Selman, Maurice H J, Trouw, Leendert A, Deelder, André M, Huizinga, Tom W J, Wuhrer, Manfred, van Schaardenburg, Dirkjan, Toes, René E M, Scherer, Hans U

“…To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific changes in Fc glycosylation prior to the onset of arthritis. Serum samples of…”
Get more information

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans by Hafkenscheid, Lise, Bondt, Albert, Scherer, Hans U., Huizinga, Tom W.J., Wuhrer, Manfred, Toes, René E.M., Rombouts, Yoann

“…Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). As N-linked glycans…”
Get full text

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis by Scally, Stephen W, Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L, Nel, Hendrik J, Loh, Khai Lee, Wijeyewickrema, Lakshmi C, Eckle, Sidonia B G, van Heemst, Jurgen, Pike, Robert N, McCluskey, James, Toes, Rene E, La Gruta, Nicole L, Purcell, Anthony W, Reid, Hugh H, Thomas, Ranjeny, Rossjohn, Jamie

“…Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and…”
Get full text

Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region by van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Heer, Pleuni Ooijevaar-de, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo

“…A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually…”
Get full text

Genetics of rheumatoid arthritis: what have we learned? by Bax, Marieke, van Heemst, Jurgen, Huizinga, Tom W. J., Toes, Rene E. M.

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5–1% of the population worldwide. The disease has a heterogeneous character, including…”
Get full text

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid by Brouwers, Hilde, Jónasdóttir, Hulda S, Kuipers, Marije E, Kwekkeboom, Joanneke C, Auger, Jennifer L, Gonzalez-Torres, Mayra, López-Vicario, Cristina, Clària, Joan, Freysdottir, Jona, Hardardottir, Ingibjorg, Garrido-Mesa, José, Norling, Lucy V, Perretti, Mauro, Huizinga, Tom W J, Kloppenburg, Margreet, Toes, René E M, Binstadt, Bryce, Giera, Martin, Ioan-Facsinay, Andreea

“…Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of inflammation. Generally, omega ( )-3 PUFAs are considered proresolving…”
Get full text

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis by Stork, Eva Maria, van Rijswijck, Danique M. H., van Schie, Karin A., Hoek, Max, Kissel, Theresa, Scherer, Hans Ulrich, Huizinga, Tom W. J., Heck, Albert J. R., Toes, Rene E. M., Bondt, Albert

“…The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune…”
Get full text

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells by Wang, Jun, Ioan‐Facsinay, Andreea, van der Voort, Ellen I. H., Huizinga, Tom W. J., Toes, René E. M.

“…Foxp3 plays a key role in CD4+CD25+ Treg cell function in mice and represents a specific marker for these cells. Despite the strong association between FOXP3…”
Get full text

Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens by Koning, Frits, Thomas, Ranjeny, Rossjohn, Jamie, Toes, Rene E.

“…Key Points Coeliac disease and rheumatoid arthritis are multifactorial HLA-associated diseases Immune responses to enzymatically modified protein antigens are…”
Get full text

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis by van der Woude, Diane, Rantapää-Dahlqvist, Solbritt, Ioan-Facsinay, Andreea, Onnekink, Carla, Schwarte, Carla M, Verpoort, Kirsten N, Drijfhout, Jan W, Huizinga, Tom W J, Toes, Rene E M, Pruijn, Ger J M

“…Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). To investigate whether the…”
Get more information

Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies by Ge, Changrong, Xu, Bingze, Liang, Bibo, Lönnblom, Erik, Lundström, Susanna L., Zubarev, Roman A., Ayoglu, Burcu, Nilsson, Peter, Skogh, Thomas, Kastbom, Alf, Malmström, Vivianne, Klareskog, Lars, Toes, René E. M., Rispens, Theo, Dobritzsch, Doreen, Holmdahl, Rikard

“…Objective Anti–citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to…”
Get full text

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis by Koppejan, Hester, Jansen, Diahann T S L, Hameetman, Marjolijn, Thomas, Ranjeny, Toes, Rene E M, van Gaalen, Floris A

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1)…”
Get full text

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis by Shi, Jing, van Steenbergen, Hanna W, van Nies, Jessica A B, Levarht, E W Nivine, Huizinga, Tom W J, van der Helm-van Mil, Annette H M, Toes, René E M, Trouw, Leendert A

“…Anti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients at risk of developing RA. To what…”
Get full text

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport by Volkov, Mikhail, Brinkhaus, Maximilian, van Schie, Karin A, Bondt, Albert, Kissel, Theresa, van der Kooi, Elvera J, Bentlage, Arthur E H, Koeleman, Carolien A M, de Taeye, Steven W, Derksen, Ninotska I, Dolhain, Radboud J E M, Braig-Scherer, Ute, Huizinga, Tom W J, Wuhrer, Manfred, Toes, René E M, Vidarsson, Gestur, van der Woude, Diane

“…Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated…”
Get full text

N‐Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis by Hafkenscheid, Lise, Moel, Emma, Smolik, Irene, Tanner, Stacey, Meng, Xiaobo, Jansen, Bas C., Bondt, Albert, Wuhrer, Manfred, Huizinga, Tom W. J., Toes, Rene E. M., El‐Gabalawy, Hani, Scherer, Hans U.

“…Objective Anti–citrullinated protein antibodies (ACPAs) are disease‐specific biomarkers in rheumatoid arthritis (RA). More than 90% of IgG ACPAs harbor…”
Get full text

TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells by Liu, Bi‐Sheng, Cao, Yonghao, Huizinga, Tom W., Hafler, David A., Toes, Rene E.M.

“…IL‐10‐producing B cells have a regulatory effect in various mouse models for immune‐mediated disorders via secretion of IL‐10, a potent immunoregulatory…”
Get full text