Search Results - "Toes, REM"

Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration by Verburg, R J, Flierman, R, Sont, J K, Ponchel, F, van Dreunen, L, Levarht, E W, Welling, M M, Toes, R E M, Isaacs, J D, van Laar, J M

“…Objective: To determine clinical and immunological correlates of high dose chemotherapy (HDC) + autologous stem cell transplantation (ASCT) in patients with…”
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Association of the CCR5 Δ32 variant with juvenile idiopathic arthritis in a meta-analysis by Reinards, THCM, Albers, HM, Brinkman, DMC, Kamphuis, SSM, van Rossum, MAJ, Hoppenreijs, EPAH, Girschick, HJ, Wouters, C, Saurenmann, RK, Houwing-Duistermaat, JJ, Toes, REM, Huizinga, TWJ, ten Cate, R, Schilham, MW

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Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications by Kissel, T, Reijm, S, Slot, L M, Cavallari, M, Wortel, C M, Vergroesen, R D, Stoeken-Rijsbergen, G, Kwekkeboom, J C, Kampstra, Asb, Levarht, Ewn, Drijfhout, J W, Bang, H, Bonger, K M, Janssen, Gmc, van Veelen, P A, Huizinga, Twj, Scherer, H U, Reth, M, Toes, Rem

“…Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of…”
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Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases by Reijm, S., Kissel, T., Toes, R.E.M.

“…B cell targeting therapies are effective in various autoimmune diseases, among others rheumatoid arthritis, pemphigus vulgaris, and systemic lupus…”
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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis by Eyre, Steve, Bowes, John, Diogo, Dorothée, Lee, Annette, Barton, Anne, Martin, Paul, Zhernakova, Alexandra, Stahl, Eli, Viatte, Sebastien, McAllister, Kate, Amos, Christopher I, Padyukov, Leonid, Toes, Rene E M, Huizinga, Tom W J, Wijmenga, Cisca, Trynka, Gosia, Franke, Lude, Westra, Harm-Jan, Alfredsson, Lars, Hu, Xinli, Sandor, Cynthia, de Bakker, Paul I W, Davila, Sonia, Khor, Chiea Chuen, Heng, Khai Koon, Andrews, Robert, Edkins, Sarah, Hunt, Sarah E, Langford, Cordelia, Symmons, Deborah, Concannon, Pat, Onengut-Gumuscu, Suna, Rich, Stephen S, Deloukas, Panos, Gonzalez-Gay, Miguel A, Rodriguez-Rodriguez, Luis, Ärlsetig, Lisbeth, Martin, Javier, Rantapää-Dahlqvist, Solbritt, Plenge, Robert M, Raychaudhuri, Soumya, Klareskog, Lars, Gregersen, Peter K, Worthington, Jane

“…Jane Worthington and colleagues use a high-density genotyping chip to identify new susceptibility loci for rheumatoid arthritis and examine genetic overlap…”
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Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss by Harre, Ulrike, Lang, Stefanie C., Pfeifle, René, Rombouts, Yoann, Frühbeißer, Sabine, Amara, Khaled, Bang, Holger, Lux, Anja, Koeleman, Carolien A., Baum, Wolfgang, Dietel, Katharina, Gröhn, Franziska, Malmström, Vivianne, Klareskog, Lars, Krönke, Gerhard, Kocijan, Roland, Nimmerjahn, Falk, Toes, René E. M., Herrmann, Martin, Scherer, Hans Ulrich, Schett, Georg

“…Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the…”
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Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies by Ge, Changrong, Xu, Bingze, Liang, Bibo, Lönnblom, Erik, Lundström, Susanna L., Zubarev, Roman A., Ayoglu, Burcu, Nilsson, Peter, Skogh, Thomas, Kastbom, Alf, Malmström, Vivianne, Klareskog, Lars, Toes, René E. M., Rispens, Theo, Dobritzsch, Doreen, Holmdahl, Rikard

“…Objective Anti–citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to…”
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Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage by Brink, Mikael, Verheul, Marije K, Rönnelid, Johan, Berglin, Ewa, Holmdahl, Rikard, Toes, Rene E M, Klareskog, Lars, Trouw, Leendert A, Rantapää-Dahlqvist, Solbritt

“…The presence of a new autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, has been identified in rheumatoid arthritis (RA). The presence of…”
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The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis by Albers, HM, Kurreeman, FAS, Houwing-Duistermaat, JJ, Brinkman, DMC, Kamphuis, SSM, Girschick, HJ, Wouters, C, van Rossum, MAJ, Verduyn, W, Toes, REM, Huizinga, TWJ, Schilham, MW, ten Cate, R

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Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies by Jiang, Xia, Trouw, Leendert A, van Wesemael, Tineke J, Shi, Jing, Bengtsson, Camilla, Källberg, Henrik, Malmström, Vivi, Israelsson, Lena, Hreggvidsdottir, Hulda, Verduijn, Willem, Klareskog, Lars, Alfredsson, Lars, Huizinga, Tom W J, Toes, Rene E M, Lundberg, Karin, van der Woude, Diane

“…In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anticitrullinated protein antibodies…”
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A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis by He, Yibo, Ge, Changrong, Moreno-Giró, Àlex, Xu, Bingze, Beusch, Christian M., Sandor, Katalin, Su, Jie, Cheng, Lei, Lönnblom, Erik, Lundqvist, Christina, Slot, Linda M., Tong, Dongmei, Urbonaviciute, Vilma, Liang, Bibo, Li, Taotao, Lahore, Gonzalo Fernandez, Aoun, Mike, Malmström, Vivianne, Rispens, Theo, Ernfors, Patrik, Svensson, Camilla I., Scherer, Hans Ulrich, Toes, René E. M., Gjertsson, Inger, Ekwall, Olov, Zubarev, Roman A., Holmdahl, Rikard

“…Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these…”
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The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor by Ajeganova, S, van Steenbergen, H W, Verheul, M K, Forslind, K, Hafström, I, Toes, R E M, Huizinga, T W J, Svensson, B, Trouw, L A, van der Helm-van Mil, A H M

“…Anti-carbamylated protein (anti-CarP) antibodies are reported to associate with more radiographic progression within the total rheumatoid arthritis (RA)…”
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Common variants at CD40 and other loci confer risk of rheumatoid arthritis by Plenge, Robert M, Raychaudhuri, Soumya, Remmers, Elaine F, Lee, Annette T, Hackett, Rachel, Guiducci, Candace, Burtt, Noël P, Gianniny, Lauren, Korman, Benjamin D, Padyukov, Leonid, Kurreeman, Fina A S, Chang, Monica, Catanese, Joseph J, Ding, Bo, Wong, Sandra, van der Helm-van Mil, Annette H M, Neale, Benjamin M, Coblyn, Jonathan, Cui, Jing, Tak, Paul P, Wolbink, Gert Jan, Crusius, J Bart A, Horst-Bruinsma, Irene E van der, Criswell, Lindsey A, Amos, Christopher I, Seldin, Michael F, Kastner, Daniel L, Ardlie, Kristin G, Alfredsson, Lars, Costenbader, Karen H, Altshuler, David, Huizinga, Tom W J, Shadick, Nancy A, Weinblatt, Michael E, de Vries, Niek, Worthington, Jane, Seielstad, Mark, Toes, Rene E M, Karlson, Elizabeth W, Begovich, Ann B, Klareskog, Lars, Gregersen, Peter K, Daly, Mark J

“…To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis of two published genome-wide association (GWA) studies…”
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Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression by de la Rica, Lorenzo, Urquiza, José M, Gómez-Cabrero, David, Islam, Abul B.M.M.K, López-Bigas, Nuria, Tegnér, Jesper, Toes, René E.M, Ballestar, Esteban

“…Abstract Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental…”
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Genetic variants at CD28 , PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk by Liu, Xiangdong, Stahl, Eli A, Martin, Paul, Costenbader, Karen H, Xie, Gang, Thomson, Brian P, Harrison, Pille, Ke, Xiayi, Cui, Jing, Kastner, Daniel L, Begovich, Ann B, Emery, Paul, Criswell, Lindsey A, Amos, Christopher I, Chang, Monica, De Jager, Phillip L, Eyre, Stephen, Burtt, Noel P, Padyukov, Leonid, Coblyn, Jonathan, Seielstad, Mark, Barton, Anne, Chen, Robert, Lee, Annette T, Gregersen, Peter K, van der Horst-Bruinsma, Irene E, Klareskog, Lars, Li, Yonghong, Hinks, Anne, Raychaudhuri, Soumya, Wilson, Anthony G, Wordsworth, Paul, Crusius, J Bart A, Alfredsson, Lars, Reid, David M, Thomson, Wendy, Remmers, Elaine F, Tak, Paul P, van der Helm-van Mil, Annette H M, Daly, Mark J, Wolbink, Gert Jan, Ding, Bo, Toes, Rene E M, Guiducci, Candace, Kurreeman, Fina A S, Morgan, Ann W, Ardlie, Kristin G, de Vries, Niek, Karlson, Elizabeth W, Worthington, Jane, Hocking, Lynne J, Altshuler, David, Steer, Sophia, Seldin, Michael F, Weinblatt, Michael E, Flynn, Edward, Huizinga, Tom W J, Plenge, Robert M, Shadick, Nancy A, Siminovitch, Katherine A, Bowes, John, Catanese, Joseph J

“…To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis…”
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Differential TLR-induced cytokine production by human mast cells is amplified by Fc epsilon RI triggering by Suurmond, J, Dorjee, AL, Knol, E F, Huizinga, TWJ, Toes, REM

“…Mast cells are mainly present in strategic locations, where they may have a role in defence against parasites and bacteria. These pathogens can be recognized…”
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Role of Anti–Carbamylated Protein Antibodies Compared to Anti–Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First‐Degree Relatives, and Healthy Controls by Koppejan, H., Trouw, L. A., Sokolove, J., Lahey, L. J., Huizinga, T. J. W., Smolik, I. A., Robinson, D. B., El‐Gabalawy, H. S., Toes, R. E. M., Hitchon, C. A.

“…Objective Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies, including seropositivity for rheumatoid factor (RF) and…”
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Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis by Källberg, Henrik, Padyukov, Leonid, Plenge, Robert M., Rönnelid, Johan, Gregersen, Peter K., van der Helm-van Mil, Annette H.M., Toes, Rene E.M., Huizinga, Tom W., Klareskog, Lars, Alfredsson, Lars

“…Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex diseases. The aim of this study…”
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Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present by Derksen, V F A M, Ajeganova, S, Trouw, L A, van der Helm-van Mil, A H M, Hafström, I, Huizinga, T W J, Toes, R E M, Svensson, B, van der Woude, D

“…In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term…”
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Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients by Germar, Kristine, Fehres, Cynthia M., Scherer, Hans U., Uden, Nathalie, Pollastro, Sabrina, Yeremenko, Nataliya, Hansson, Monika, Kerkman, Priscilla F., Voort, Ellen I. H., Reed, Evan, Maassen, Hanna, Kwakkenbos, Mark J., Bakker, Arjen Q., Klareskog, Lars, Malmström, Vivianne, Vries, Niek, Toes, René E. M., Lundberg, Karin, Spits, Hergen, Baeten, Dominique L.

“…Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA). Aside from autoantibody production, the function of…”
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