Search Results - "Toes, R"

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review by de Lange-Brokaar, B.J.E, Ioan-Facsinay, A, van Osch, G.J.V.M, Zuurmond, A.-M, Schoones, J, Toes, R.E.M, Huizinga, T.W.J, Kloppenburg, M

“…Summary Objective Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA…”
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The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor by Ajeganova, S, van Steenbergen, H W, Verheul, M K, Forslind, K, Hafström, I, Toes, R E M, Huizinga, T W J, Svensson, B, Trouw, L A, van der Helm-van Mil, A H M

“…Anti-carbamylated protein (anti-CarP) antibodies are reported to associate with more radiographic progression within the total rheumatoid arthritis (RA)…”
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Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands by van Zanten, A, Arends, S, Roozendaal, C, Limburg, P C, Maas, F, Trouw, L A, Toes, R E M, Huizinga, T W J, Bootsma, H, Brouwer, E

“…To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the…”
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Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases by Reijm, S., Kissel, T., Toes, R.E.M.

“…B cell targeting therapies are effective in various autoimmune diseases, among others rheumatoid arthritis, pemphigus vulgaris, and systemic lupus…”
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The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype by Klein-Wieringa, I R, Kloppenburg, M, Bastiaansen-Jenniskens, Y M, Yusuf, E, Kwekkeboom, J C, El-Bannoudi, H, Nelissen, R G H H, Zuurmond, A, Stojanovic-Susulic, V, Van Osch, G J V M, Toes, R E M, Ioan-Facsinay, A

“…Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful…”
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A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels by Messemaker, T C, Frank-Bertoncelj, M, Marques, R B, Adriaans, A, Bakker, A M, Daha, N, Gay, S, Huizinga, T W, Toes, R E M, Mikkers, H M M, Kurreeman, F

“…Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated…”
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Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters by de Lange-Brokaar, B.J.E, Kloppenburg, M, Andersen, S.N, Dorjée, A.L, Yusuf, E, Herb-van Toorn, L, Kroon, H.M, Zuurmond, A.-M, Stojanovic-Susulic, V, Bloem, J.L, Nelissen, R.G.H.H, Toes, R.E.M, Ioan-Facsinay, A

“…Summary Objective To investigate the presence of mast cells in the osteoarthritic (OA) synovium and their association with clinical parameters in comparison…”
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Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications by Volkov, M, Kampstra, A S B, van Schie, K A, Kawakami, A, Tamai, M, Kawashiri, S, Maeda, T, Huizinga, T W J, Toes, R E M, van der Woude, D

“…Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other…”
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Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status by Koppejan, H, Hameetman, M, Beyrend, G, van Unen, V, Kwekkeboom, J. C, van der Helm-van Mil, A. H, Toes, R. E. M, van Gaalen, F. A

“…Abstract Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly…”
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Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present by Derksen, V F A M, Ajeganova, S, Trouw, L A, van der Helm-van Mil, A H M, Hafström, I, Huizinga, T W J, Toes, R E M, Svensson, B, van der Woude, D

“…In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term…”
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Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis by Suwannalai, P., van de Stadt, L. A., Radner, H., Steiner, G., El-Gabalawy, H. S., Zijde, C. M. Jol-van der, van Tol, M. J., van Schaardenburg, D., Huizinga, T. W. J., Toes, R. E. M., Trouw, L. A.

“…Objective Anti–citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and are present years before the onset of symptoms…”
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Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia by Ten Brinck, R M, Toes, R E M, van der Helm-van Mil, A H M

“…Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is…”
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T-cell co-stimulation by CD28–CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development by Ewing, M.M, Karper, J.C, Abdul, S, de Jong, R.C.M, Peters, H.A.B, de Vries, M.R, Redeker, A, Kuiper, J, Toes, R.E.M, Arens, R, Jukema, J.W, Quax, P.H.A

“…Abstract Objective T-cells are central to the immune response responsible for native atherosclerosis. The objective of this study is to investigate T-cell…”
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Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications by Kissel, T, Reijm, S, Slot, L M, Cavallari, M, Wortel, C M, Vergroesen, R D, Stoeken-Rijsbergen, G, Kwekkeboom, J C, Kampstra, Asb, Levarht, Ewn, Drijfhout, J W, Bang, H, Bonger, K M, Janssen, Gmc, van Veelen, P A, Huizinga, Twj, Scherer, H U, Reth, M, Toes, Rem

“…Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of…”
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Effect of Antigen Valency on Autoreactive B‑Cell Targeting by van Weijsten, M. J., Venrooij, K. R., Lelieveldt, L.P.W.M., Kissel, T., van Buijtenen, E., van Dalen, F. J., Verdoes, M., Toes, R.E.M., Bonger, K. M.

“…Many autoimmune diseases are characterized by B cells that mistakenly recognize autoantigens and produce antibodies toward self-proteins. Current therapies aim…”
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A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis by van der Helm-van Mil, A H M, van der Kooij, S M, Allaart, C F, Toes, R E M, Huizinga, T W J

“…Obesity is a state of chronic low-grade inflammation that predisposes people to several diseases and that is increasingly prevalent. Rheumatoid arthritis (RA)…”
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Complement component C1q is produced by isolated articular chondrocytes by Lubbers, R., van Schaarenburg, R.A., Kwekkeboom, J.C., Levarht, E.W.N., Bakker, A.M., Mahdad, R., Monteagudo, S., Cherifi, C., Lories, R.J., Toes, R.E.M., Ioan-Facsinay, A., Trouw, L.A.

“…Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the…”
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Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans by Jónasdóttir, Hulda S., MSc, Brouwers, Hilde, MSc, Kwekkeboom, Joanneke C., Ing, van der Linden, Enrike M.J., MD, PhD, Huizinga, Tom, MD, PhD, Kloppenburg, Margreet, MD, PhD, Toes, Rene E.M., PhD, Giera, Martin, PhD, Ioan-Facsinay, Andreea, PhD

“…Summary Objective To investigate the presence of inflammation and resolution pathways in osteoarthritis (OA). Design Tissues were obtained from knee OA…”
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Pitfalls in the detection of citrullination and carbamylation by Verheul, M.K., van Veelen, P.A., van Delft, M.A.M., de Ru, A., Janssen, G.M.C., Rispens, T., Toes, R.E.M., Trouw, L.A.

“…Carbamylation and citrullination are both post-translational modifications against which (auto)antibodies can be detected in sera of rheumatoid arthritis (RA)…”
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Differential TLR-induced cytokine production by human mast cells is amplified by FcɛRI triggering by Suurmond, J., Dorjée, A. L., Knol, E. F., Huizinga, T. W. J., Toes, R. E. M.

“…Summary Background Mast cells are mainly present in strategic locations, where they may have a role in defence against parasites and bacteria. These pathogens…”
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