Search Results - "Toerne, C."

Comparison of different approaches for assessment of HER2 expression on protein and mRNA level: prediction of chemotherapy response in the neoadjuvant GeparTrio trial (NCT00544765) by Noske, A, Loibl, S, Darb-Esfahani, S, Roller, M, Kronenwett, R, Müller, B. M, Steffen, J, von Toerne, C, Wirtz, R, Baumann, I, Hoffmann, G, Heinrich, G, Grasshoff, S. T, Ulmer, H. U, Denkert, C, von Minckwitz, G

“…Human epidermal growth factor receptor 2 (HER2) testing is an essential part of pathological assessment in breast cancer patients, as HER2 provides not only…”
Get full text

A common atopy‐associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding by Kretschmer, A., Möller, G., Lee, H., Laumen, H., Toerne, C., Schramm, K., Prokisch, H., Eyerich, S., Wahl, S., Baurecht, H., Franke, A., Claussnitzer, M., Eyerich, K., Teumer, A., Milani, L., Klopp, N., Hauck, S. M., Illig, T., Peters, A., Waldenberger, M., Adamski, J., Reischl, E., Weidinger, S.

“…Background Type 2 immune responses directed by Th2 cells and characterized by the signature cytokines IL4, IL5, and IL13 play major pathogenic roles in atopic…”
Get full text

Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation by Lee, Heekyoung, Qian, Kun, von Toerne, Christine, Hoerburger, Lena, Claussnitzer, Melina, Hoffmann, Christoph, Glunk, Viktoria, Wahl, Simone, Breier, Michaela, Eck, Franziska, Jafari, Leili, Molnos, Sophie, Grallert, Harald, Dahlman, Ingrid, Arner, Peter, Brunner, Cornelia, Hauner, Hans, Hauck, Stefanie M, Laumen, Helmut

“…Genome-wide association studies identified numerous disease risk loci. Delineating molecular mechanisms influenced by cis-regulatory variants is essential to…”
Get full text

Wnt Pathway Regulation in Chronic Renal Allograft Damage by Von Toerne, C., Schmidt, C., Adams, J., Kiss, E., Bedke, J., Porubsky, S., Gretz, N., Lindenmeyer, M. T., Cohen, C. D., Gröne, H.‐J., Nelson, P. J.

“…The Wnt signaling pathway, linked to development, has been proposed to be recapitulated during the progressive damage associated with chronic organ failure…”
Get full text

Modulation of Wnt and Hedgehog Signaling Pathways Is Linked to Retinoic Acid‐Induced Amelioration of Chronic Allograft Dysfunction by von Toerne, C., Bedke, J., Safi, S., Porubsky, S., Gretz, N., Loewe, R., Nelson, P. J., Gröne, H.‐J.

“…Chronic renal allograft damage (CAD) is manifested by a smoldering inflammatory process that leads to transplant glomerulopathy, diffuse interstitial fibrosis…”
Get full text

Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort by Kühn, A., Nieters, A., Köttgen, A., Goek, O.N., Michels, K., Nöthlings, U., Jacobs, G., Meisinger, C., Pessler, F., Akmatov, M.F., Kühnisch, J., Moebus, S., Glocker, E., Naus, S., Keimling, M., Leitzmann, M., Linseisen, J., Sarioglu, H., von Toerne, C., Hauck, S.M., Wallaschofski, H., Wichmann, H.E., Illig, Thomas

“…Background The German National Cohort (GNC) is designed to address research questions concerning a wide range of possible causes of major chronic diseases…”
Get full text

0047 Validation of the prognostic impact of Ep-CAM in untreated node-negative breast cancer by Schmidt, M, von Toerne, C, Boehm, D, Cotarelo, C, Lebrecht, A, Lehr, H, Koelbl, H, Gehrmann, M, Hengstler, J.G

Get full text

Deciphering the Plasma Proteome of Type 2 Diabetes by Elhadad, Mohamed A, Jonasson, Christian, Huth, Cornelia, Wilson, Rory, Gieger, Christian, Matias, Pamela, Grallert, Harald, Graumann, Johannes, Gailus-Durner, Valerie, Rathmann, Wolfgang, von Toerne, Christine, Hauck, Stefanie M, Koenig, Wolfgang, Sinner, Moritz F, Oprea, Tudor I, Suhre, Karsten, Thorand, Barbara, Hveem, Kristian, Peters, Annette, Waldenberger, Melanie

“…With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma…”
Get full text

418 Identification of new cell surface targets on human T helper cells by Graessel, A., Hauck, S., von Toerne, C., Kloppmann, E., Goldberg, T., Koppensteiner, H., Schindler, M., Krause, L., Schmidt-Weber, C., Blank, S.

Get full text

RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy by Denkert, C., Loibl, S., Kronenwett, R., Budczies, J., von Törne, C., Nekljudova, V., Darb-Esfahani, S., Solbach, C., Sinn, B.V., Petry, C., Müller, B.M., Hilfrich, J., Altmann, G., Staebler, A., Roth, C., Ataseven, B., Kirchner, T., Dietel, M., Untch, M., von Minckwitz, G.

“…Hormone and human epidermal growth factor receptor 2 (HER2) receptors are the most important breast cancer biomarkers, and additional objective and…”
Get full text

Expression of the cellular and the humoral immune system in triple-negative carcinomas of the breast—Impact on prognosis? by Schmidt, M., von Toerne, C., Koelbl, H., Gehrmann, M.

“…Abstract only…”
Get full text

A common atopy‐associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD 3 and SP 1 binding by Kretschmer, A., Möller, G., Lee, H., Laumen, H., von Toerne, C., Schramm, K., Prokisch, H., Eyerich, S., Wahl, S., Baurecht, H., Franke, A., Claussnitzer, M., Eyerich, K., Teumer, A., Milani, L., Klopp, N., Hauck, S. M., Illig, T., Peters, A., Waldenberger, M., Adamski, J., Reischl, E., Weidinger, S.

“…Abstract Background Type 2 immune responses directed by T h2 cells and characterized by the signature cytokines IL 4, IL 5, and IL 13 play major pathogenic…”
Get full text

High TOP2A mRNA expression occurs in the absence of TOP2A or ERBB2 gene amplification by Gehrmann, M., Fischbach, T., Hengstler, J., von Toerne, C., Kölbl, H., Schmidt, M.

“…Abstract only…”
Get full text

Prognostic algorithm identified in node-negative early breast cancer patients predicts outcome also in node-positive patients treated with adjuvant chemotherapy by Kronenwett, R, Kalogeras, KT, Stropp, U, Weber, K, Dafni, U, Gehrmann, M, Pectasides, D, von Toerne, C, Papakostas, P, Wirtz, RM, Fountzilas, G

“…Abstract Abstract #6044 Background: Recently, we identified and validated a prognostic multigene score, which predicted outcome in early node-negative breast…”
Get full text

Local versus central HER2 immunohistochemistry correlates with kinetic RT-PCR but only central immunohistochemistry and RT-PCR predict pathological complete response: results from the neoadjuvant multicenter GeparTrio trial by Loibl, S, Müller, B, Roller, M, Kronenwett, R, Darb-Esfahani, S, Komor, M, von Toerne, C, Wirtz, R, von Minckwitz, G, Denkert, C

“…Abstract Abstract #1070 Background: There are several methods for determination of HER2 overexpression. Immunohistochemistry (IHC) has been set up as the gold…”
Get full text

Prognostic impact of MKI67 and MMP1 in node-negative invasive ductal and invasive lobular carcinoma of the breast by Schmidt, M., Boehm, D., von Toerne, C., Lehr, H. A., Hengstler, J. G., Koelbl, H., Gehrmann, M.

“…Abstract only 21102 Background: MKI67 and MMP1 mRNA, which might reflect the biological processes of tumor proliferation and matrix degradation, respectively,…”
Get full text

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon by Spieler, Derek, Kaffe, Maria, Knauf, Franziska, Bessa, José, Tena, Juan J, Giesert, Florian, Schormair, Barbara, Tilch, Erik, Lee, Heekyoung, Horsch, Marion, Czamara, Darina, Karbalai, Nazanin, von Toerne, Christine, Waldenberger, Melanie, Gieger, Christian, Lichtner, Peter, Claussnitzer, Melina, Naumann, Ronald, Müller-Myhsok, Bertram, Torres, Miguel, Garrett, Lillian, Rozman, Jan, Klingenspor, Martin, Gailus-Durner, Valérie, Fuchs, Helmut, Hrabě de Angelis, Martin, Beckers, Johannes, Hölter, Sabine M, Meitinger, Thomas, Hauck, Stefanie M, Laumen, Helmut, Wurst, Wolfgang, Casares, Fernando, Gómez-Skarmeta, Jose Luis, Winkelmann, Juliane

“…Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their…”
Get full text

Genexpressionsanalysen zeigen fundamentale Unterschiede zwischen invasiv-duktalen und invasiv-lobulären Mammakarzinomen by Schmidt, M, Törne, C von, Böhm, D, Lebrecht, A, Siggelkow, W, Pilch, H, Steiner, E, Lehr, HA, Hengstler, JG, Gehrmann, M, Kölbl, H

“…Abstract only…”
Get full text

Zusammenhang zwischen Genexpressionsmustern und Lebensalter bei Patientinnen mit primärem Mammakarzinom by Schmidt, M, von Törne, C, Böhm, D, Steiner, E, Glawatz, C, Puhl, A, Pilch, H, Lehr, HA, Weikel, W, Hengslter, JG, Kölbl, H, Gehrmann, M

“…Abstract only…”
Get full text

Prädiktive und prognostische Brustkrebsmarker: Molekularbiologische Analyse von fixiertem Tumorgewebe als Basis by Petry, C., Gehrmann, M., von Törne, C., Weber, K., Stropp, U., Hennig, G.

“…Zusammenfassung In den zurückliegenden Jahren sind zahlreiche prognostische und prädiktive Multiparameteralgorithmen, basierend auf der Analyse von…”
Get full text