Search Results - "Todorova, Valentina K."

Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer by Todorova, Valentina K, Azhar, Gohar, Stone, Annjanette, Malapati, Sindhu J, Che, Yingni, Zhang, Wei, Makhoul, Issam, Wei, Jeanne Y

“…Doxorubicin (DOX), a commonly used anticancer agent, causes cardiotoxicity that begins with the first dose and may progress to heart failure years after…”
Get full text

Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer by Todorova, Valentina K, Byrum, Stephanie D, Gies, Allen J, Haynie, Cade, Smith, Hunter, Reyna, Nathan S, Makhoul, Issam

“…Neoadjuvant chemotherapy (NACT) is an increasingly used approach for treatment of breast cancer. The pathological complete response (pCR) is considered a good…”
Get full text

Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer by Hsu, Ping-Ching, Kadlubar, Susan A, Siegel, Eric R, Rogers, Lora J, Todorova, Valentina K, Su, L Joseph, Makhoul, Issam

“…ClinicalTrials.gov Identifier: NCT00203502…”
Get full text

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells by Todorova, Valentina K, Byrum, Stephanie D, Mackintosh, Samuel G, Jamshidi-Parsian, Azemat, Gies, Allen J, Washam, Charity L, Jenkins, Samir V, Spiva, Timothy, Bowman, Emily, Reyna, Nathan S, Griffin, Robert J, Makhoul, Issam

“…Infection with hepatitis B virus (HBV) is a main risk factor for hepatocellular carcinoma (HCC). Extracellular vesicles, such as exosomes, play an important…”
Get full text

Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients by Todorova, Valentina K, Makhoul, Issam, Siegel, Eric R, Wei, Jeanne, Stone, Annjanette, Carter, Weleetka, Beggs, Marjorie L, Owen, Aaron, Klimberg, V Suzanne

“…Cardiotoxicity of doxorubicin (DOX) remains an important health concern. DOX cardiotoxicity is cumulative-dose-dependent and begins with the first dose of…”
Get full text

Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model by Todorova, Valentina K., Siegel, Eric R., Kaufmann, Yihong, Kumarapeli, Asangi, Owen, Aaron, Wei, Jeanne Y., Makhoul, Issam, Klimberg, V. Suzanne

“…Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic…”
Get full text

Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients by Makhoul, Issam, Todorova, Valentina K, Siegel, Eric R, Erickson, Stephen W, Dhakal, Ishwori, Raj, Vinay R, Lee, Jeannette Y, Orloff, Mohammed S, Griffin, Robert J, Henry-Tillman, Ronda S, Klimberg, Suzanne, Hutchins, Laura F, Kadlubar, Susan A

“…We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with…”
Get full text

Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model by Todorova, Valentina K, Beggs, Marjorie L, Delongchamp, Robert R, Dhakal, Ishwori, Makhoul, Issam, Wei, Jeanne Y, Klimberg, V Suzanne

“…Doxorubicin (DOX), a widely used anticancer agent, can cause an unpredictable cardiac toxicity which remains a major limitation in cancer chemotherapy. There…”
Get full text

Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake by Todorova, Valentina K, Kaufmann, Yihong, Luo, Shaoke, Suzanne Klimberg, V

“…Purpose Modulation of estrogen receptor (ER) plays a central role in selective estrogen receptor modulators (SERMs) molecular mechanism of action, although…”
Get full text

Oral glutamine protects against acute doxorubicin-induced cardiotoxicity of tumor-bearing rats by Todorova, Valentina K, Kaufmann, Yihong, Hennings, Leah, Klimberg, V Suzanne

“…Doxorubicin (DOX), a widely used anticancer drug, has a dose-dependent cardiotoxicity, attributed mainly to free radical formation. The cardiomyocyte oxidative…”
Get more information

Correction: Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model by Todorova, Valentina K., Beggs, Marjorie L., Delongchamp, Robert R., Dhakal, Ishwori, Makhoul, Issam, Wei, Jeanne Y., Klimberg, V. Suzanne

“…The following information was missing from the Funding section: NIH grant (#AG028718) with a pilot project grant to VKT. (2013) Correction: Transcriptome…”
Get full text

Glutamine regulation of doxorubicin accumulation in hearts versus tumors in experimental rats by Todorova, Valentina K, Kaufmann, Yihong, Hennings, Leah J, Klimberg, V. Suzanne

“…Purpose Doxorubicin (DOX), an effective antineoplastic agent is known for its cardiotoxicity attributed mainly to free radical formation. Preliminary data…”
Get full text

RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity by Todorova, Valentina K., Bauer, Michael A., Azhar, Gohar, Wei, Jeanne Y.

“…Gene expression of formalin-fixed paraffin-embedded (FFPE) tissue may serve for molecular studies on cardiovascular diseases. Chemotherapeutics, such as…”
Get full text

Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients by Todorova, Valentina K, Makhoul, Issam, Wei, Jeanne, Klimberg, V S

“…Doxorubicin (DOX) cardiotoxicity is unpredictable and begins with the first dose of chemotherapy. This study aimed to obtain information about circulating…”
Get more information

Subclinical doxorubicin-induced cardiotoxicity update: role of neutrophils and endothelium by Todorova, Valentina K, Wei, Jeanne Y, Makhoul, Issam

“…Doxorubicin (DOX) is a highly effective chemotherapy agent that often causes cardiotoxicity. Despite a number of extensive studies, the risk for DOX…”
Get full text

Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma by Jamshidi-Parsian, Azemat, Griffin, Robert J., Kore, Rajshekhar A., Todorova, Valentina K., Makhoul, Issam

“…Hepatocellular carcinoma (HCC) is a densely vascularized tumor that is highly dependent on angiogenic pathways to direct arterial blood flow to the growing…”
Get full text

Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients by Yu, Li-Rong, Cao, Zhijun, Makhoul, Issam, Daniels, Jaclyn R, Klimberg, Suzanne, Wei, Jeanne Y, Bai, Jane PF, Li, Jinong, Lathrop, Julia T, Beger, Richard D, Todorova, Valentina K

“…Cancer treatment with doxorubicin (DOX) can induce cumulative dose-dependent cardiotoxicity. Currently, there are no specific biomarkers that can identify…”
Get full text

Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients by Todorova, Valentina K, Hsu, Ping-Ching, Wei, Jeanne Y, Lopez-Candales, Angel, Chen, Jim Zhongning, Su, L Joseph, Makhoul, Issam

“…Doxorubicin (DOX)-induced cardiotoxicity is a major limitation to its clinical application. Cardiotoxicity of DOX is dose-dependent that begins with the first…”
Get full text

Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients by Todorova, Valentina K., Makhoul, Issam, Dhakal, Ishwori, Wei, Jeanne, Stone, Annjanette, Carter, Weleetka, Owen, Aaron, Klimberg, V. Suzanne

“…Doxorubicin (DOX) is a commonly used antineoplastic agent for the treatment of various malignancies, and its use is associated with unpredictable…”
Get full text

Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer by Bauer, Michael A, Todorova, Valentina K, Stone, Annjanette, Carter, Weleetka, Plotkin, Matthew D, Hsu, Ping-Ching, Wei, Jeanne Y, Su, Joseph L, Makhoul, Issam

“…Chemotherapy with doxorubicin (DOX) may cause unpredictable cardiotoxicity. This study aimed to determine whether the methylation signature of peripheral blood…”
Get full text