Search Results - "Todorova, Krassimira"

Restoring mitophagy in prostate cancer cells: the role of miR-141 rescue in counteracting MAPK1/ERK2-dependent autophagy suppression by Tsvetankova, Radostina, Tsvetkova, Ilka, Hayrabedyan, Soren, Todorova, Krassimira

“…Prostate cancer (PCa) stands as one of the most prevalent malignancies in men, ranking as the fifth leading cancer-associated mortality. Castration-resistance…”
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TLR4 signalling protects Sertoli cells from cell stress via reprogramming inflammasome and autophagy pathways in MAPK1/ERK2 dependent way by Avramska, Elina, Tsvetkova, Ilka, Todorova, Krassimira, Hayrabedyan, Soren

“…Sertoli cells constitutively maintain the spermatogonial stem cell niche and blood-testis barrier via impenetrable tight junctions under hormonal, growth…”
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Autophagy and SARS-CoV-2-Old Players in New Games by Ivanova, Tsvetomira, Mariienko, Yuliia, Mehterov, Nikolay, Kazakova, Maria, Sbirkov, Yordan, Todorova, Krassimira, Hayrabedyan, Soren, Sarafian, Victoria

“…At present it is well-defined that autophagy is a fundamental process essential for cell life but its pro-viral and anti-viral role has been stated out with…”
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Single-cell transcriptomics in the context of long-read nanopore sequencing by Hayrabedyan, Soren, Kostova, Petya, Zlatkov, Viktor, Todorova, Krassimira

“…Single cell transcriptomics were declared twice 'Method of the year' by Nature Methods journal, in 2013 and 2019. It marks the beginning of new avenue in…”
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Machine Learning Approach for Muscovy Duck ( Cairina moschata ) Semen Quality Assessment by Abadjieva, Desislava, Georgiev, Boyko, Gerzilov, Vasko, Tsvetkova, Ilka, Taushanova, Paulina, Todorova, Krassimira, Hayrabedyan, Soren

“…This study aimed to develop a comprehensive approach for assessing fresh ejaculate from Muscovy duck ( ) drakes to fulfil the requirements of artificial…”
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Synthetic PreImplantation Factor (sPIF) induces posttranslational protein modification and reverses paralysis in EAE mice by Hayrabedyan, Soren, Shainer, Reut, Yekhtin, Zhanna, Weiss, Lola, Almogi-Hazan, Osnat, Or, Reuven, Farnsworth, Charles L., Newsome, Scott, Todorova, Krassimira, Paidas, Michael J., Brodie, Chaya, Barnea, Eytan R., Mueller, Martin

“…An autoimmune response against myelin protein is considered one of the key pathogenic processes that initiates multiple sclerosis (MS). The currently available…”
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SARS-CoV-2 vertical transmission supports innate fetal protection: A narrative review by Barnea, Eytan R., Di Simone, Nicoletta, Hayrabedyan, Soren, Todorova, Krassimira, Inversetti, Annalisa, Vento, Giovanni, Costa, Simonetta

“…Prenatal infections that have been exhaustively studied help frame the current Severe Acute Respiratory Syndrome related coronavirus-2 (SARS-CoV-2) pandemic,…”
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Preimplantation Factor (PIF) Promotes HLA-G, -E, -F, -C Expression in JEG-3 Choriocarcinoma Cells and Endogenous Progesterone Activity by Hakam, Miya Soukaina, Miranda-Sayago, Jose Maria, Hayrabedyan, Soren, Todorova, Krassimira, Spencer, Patrick Simon, Jabeen, Asma, Barnea, Eytan R., Fernandez, Nelson

“…Background/Aims: Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of…”
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Structural design-based preimplantation factor (PIF) fusion peptide synthetic DNA cloning and eukaryote expression aimed for functional proteomic studies and possible chronic immune disorders therapy by Hayrabedyan, Soren B, Todorova, Krassimira O, Barnea, Eytan R

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Preimplantation factor (PIF) shares a common RIPK target to regulate global immune function required for maintained homeostasis by Hayrabedyan, Soren B, Kirk, David, Todorova, Krassimira O, Barnea, Eytan R

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NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells by Hayrabedyan, Soren B, Zasheva, Diana Y, Todorova, Krassimira O

“…The present study aims to investigate the NALP3 system and its effect on claudins in Sertoli cells using a mouse adult Sertoli cell line as a model. We focus…”
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Insight into PreImplantation Factor (PIF) mechanism for embryo protection and development: target oxidative stress and protein misfolding (PDI and HSP) through essential RIKP [corrected] binding site by Barnea, Eytan R, Lubman, David M, Liu, Yan-Hui, Absalon-Medina, Victor, Hayrabedyan, Soren, Todorova, Krassimira, Gilbert, Robert O, Guingab, Joy, Barder, Timothy J

“…Endogenous PIF, upon which embryo development is dependent, is secreted only by viable mammalian embryos, and absent in non-viable ones. Synthetic PIF (sPIF)…”
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Basal cell subpopulation as putative human prostate carcinoma stem cells by Kuzmanov, Aleksandar, Hayrabedyan, Soren, Karaivanov, Milen, Todorova, Krassimira

“…The present study examines the expression of p63, glutathione S-transferase-pi (GSTP1) and alpha-methylacyl-CoAracemase (AMACR) in serial slices in…”
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Endothelial inflammation and dysfunction in COVID-19 by Sbirkov, Yordan, Dzharov, Vasil, Todorova, Krassimira, Hayrabedyan, Soren, Sarafian, Victoria

“…The biggest challenge in the COVID-19 pandemic besides the spread of the SARS-CoV-2 virus is to reduce mortality rates. As the number of cases continues to…”
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FRI-152-Immunoregulatory activity of preimplantation-factor on HCV stimulated primary human hepatocytes demonstrates preclinical activity for treating inflammatory liver diseases by Thomas, Emmanuel, Edwards, Jasmine, Badilla, Alejandro, O’brien, Christopher, Todorova, Krassimira, Hayrabedyan, Soren, Barnea, Eytan

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Alternative RNA Splicing-The Trojan Horse of Cancer Cells in Chemotherapy by Mehterov, Nikolay, Kazakova, Maria, Sbirkov, Yordan, Vladimirov, Boyan, Belev, Nikolay, Yaneva, Galina, Todorova, Krassimira, Hayrabedyan, Soren, Sarafian, Victoria

“…Almost all transcribed human genes undergo alternative RNA splicing, which increases the diversity of the coding and non-coding cellular landscape. The…”
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miR-204 is dysregulated in metastatic prostate cancer in vitro by Todorova, Krassimira, Metodiev, Metodi V., Metodieva, Gergana, Zasheva, Diana, Mincheff, Milcho, Hayrabedyan, Soren

“…During cancer progression, the genome instability incurred rearrangement could possibly turn some of the tumor suppressor micro‐RNAs into pro‐oncogenic ones…”
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The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease by Hayrabedyan, Soren, Todorova, Krassimira, Spinelli, Marialuigia, Barnea, Eytan R, Mueller, Martin

“…The central pathological feature of Alzheimer's disease (AD) is the sequential proteolytic processing of amyloid precursor protein (APP) to amyloid-β peptides…”
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Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production by Hayrabedyan, Soren, Todorova, Krassimira, Jabeen, Asma, Metodieva, Gergana, Toshkov, Stavri, Metodiev, Metodi V., Mincheff, Milcho, Fernández, Nelson

“…Sertoli cells, can function as non-professional tolerogenic antigen-presenting cells and sustain the blood-testis barrier formed by their tight junctions. The…”
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PIF direct immune regulation: Blocks mitogen-activated PBMCs proliferation, promotes TH2/TH1 bias, independent of Ca(2+) by Barnea, Eytan R, Kirk, David, Todorova, Krassimira, McElhinney, James, Hayrabedyan, Soren, Fernández, Nelson

“…PreImplantation Factor (PIF(9&15)) secreted by viable embryos exerts an essential transplant acceptance and immune regulatory role in pregnancy. Synthetic PIF…”
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