Mosquito vector competence for dengue is modulated by insect-specific viruses

Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted int...

Full description

Saved in:

Bibliographic Details
Published in:	Nature microbiology Vol. 8; no. 1; pp. 135 - 149
Main Authors:	Olmo, Roenick P., Todjro, Yaovi M. H., Aguiar, Eric R. G. R., de Almeida, João Paulo P., Ferreira, Flávia V., Armache, Juliana N., de Faria, Isaque J. S., Ferreira, Alvaro G. A., Amadou, Siad C. G., Silva, Ana Teresa S., de Souza, Kátia P. R., Vilela, Ana Paula P., Babarit, Antinea, Tan, Cheong H., Diallo, Mawlouth, Gaye, Alioune, Paupy, Christophe, Obame-Nkoghe, Judicaël, Visser, Tessa M., Koenraadt, Constantianus J. M., Wongsokarijo, Merril A., Cruz, Ana Luiza C., Prieto, Mariliza T., Parra, Maisa C. P., Nogueira, Maurício L., Avelino-Silva, Vivian, Mota, Renato N., Borges, Magno A. Z., Drumond, Betânia P., Kroon, Erna G., Recker, Mario, Sedda, Luigi, Marois, Eric, Imler, Jean-Luc, Marques, João T.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-01-2023 Nature Publishing Group
Subjects:	38/90 45/91 631/326/596/1413 631/326/596/2142 631/326/596/2557 631/326/596/2563 Aedes Animals Arboviruses - genetics Biomedical and Life Sciences Culicidae Dengue Dengue fever Dengue Virus - genetics Histone H4 Humans Immunology Infectious Diseases Insect Viruses - physiology Life Sciences Medical Microbiology Metagenomics Microbiology Mosquito Vectors Mosquitoes Parasitology Public health RNA Viruses Transcriptomics Vector-borne diseases Vectors Virology Viruses Zika virus Zika Virus - genetics Zika Virus Infection
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. Reasoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban Aedes mosquitoes collected from 12 countries worldwide. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most abundant in A. aegypti worldwide. Spatiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having DENV in wild A. aegypti mosquitoes when both HTV and PCLV were present. Using a mouse model in the laboratory, we showed that the presence of HTV and PCLV increased the ability of mosquitoes to transmit DENV and ZIKV to a vertebrate host. By transcriptomic analysis, we found that in DENV-infected mosquitoes, HTV and PCLV block the downregulation of histone H4, which we identify as an important proviral host factor in vivo. From metagenomics of Aedes mosquitoes from four continents, the authors analyse the mechanism by which insect-specific viruses affect mosquito vector competence to transmit dengue virus to humans.
ISSN:	2058-5276 2058-5276
DOI:	10.1038/s41564-022-01289-4