Symmetrical and Asymmetrical Cyanine Dyes. Synthesis, Spectral Properties, and BSA Association Study

Symmetrical and Asymmetrical Cyanine Dyes. Synthesis, Spectral Properties, and BSA Association Study

New cyanines were prepared by an efficient and practical route with satisfactory overall yield from low-cost starting materials. The photophysical behavior of the cyanines was investigated using UV–vis and steady-state fluorescence in solution, as well as their association with bovine serum albumin...

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Bibliographic Details
Published in:Journal of organic chemistry Vol. 79; no. 12; pp. 5511 - 5520
Main Authors: Pisoni, Diego S, Todeschini, Letícia, Borges, Antonio César A, Petzhold, Cesar L, Rodembusch, Fabiano S, Campo, Leandra F
Format: Journal Article
Language:English
Published: United States American Chemical Society 20-06-2014
Subjects:
Buffers
Carbocyanines - chemistry
Coloring Agents - chemistry
Fluorescent Dyes - chemistry
Nitrogen - chemistry
Serum Albumin, Bovine - chemical synthesis
Serum Albumin, Bovine - chemistry
Solutions - chemistry
Ultraviolet Rays
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Summary:New cyanines were prepared by an efficient and practical route with satisfactory overall yield from low-cost starting materials. The photophysical behavior of the cyanines was investigated using UV–vis and steady-state fluorescence in solution, as well as their association with bovine serum albumin (BSA) in phosphate buffer solution (PBS). No cyanine aggregation was observed in organic solvents or in phosphate buffer solution. The alkyl chain length in the quaternized nitrogen was shown to be fundamental for BSA detection in PBS in these dyes.
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ISSN:0022-3263
1520-6904
DOI:10.1021/jo500657s