Search Results - "Todderud, Gordon"

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer by Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D, Trainor, George L, Gottardis, Marco M, Spires, Thomas E, Spires, Vanessa M, Rizzo, Cheryl A, Obermeier, Mary T, Elzinga, Paul A, Todderud, Gordon, Fan, Yi, Newitt, John A, Beyer, Sophie M, Zhu, Yongxin, Warrack, Bethanne M, Goodenough, Angela K, Tebben, Andrew J, Doweyko, Arthur M, Gold, David L, Balog, Aaron

“…Efforts to identify a potent, reversible, nonsteroidal CYP17A1 lyase inhibitor with good selectivity over CYP17A1 hydroxylase and CYPs 11B1 and 21A2 for the…”
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BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions by Todderud, G, Nair, X, Lee, D, Alford, J, Davern, L, Stanley, P, Bachand, C, Lapointe, P, Marinier, A, Martel, A, Menard, M, Wright, J J, Bajorath, J, Hollenbaugh, D, Aruffo, A, Tramposch, K M

“…Selectin binding is the first step in extravasation of leukocytes through the endothelium. Infiltration of leukocytes is a hallmark of an inflammatory…”
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Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening by Posy, Shana L, Hermsmeier, Mark A, Vaccaro, Wayne, Ott, Karl-Heinz, Todderud, Gordon, Lippy, Jonathan S, Trainor, George L, Loughney, Deborah A, Johnson, Stephen R

“…A kinome-wide selectivity screen of >20000 compounds with a rich representation of many structural classes has been completed. Analysis of the selectivity…”
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Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects by Constantine, Keith L, Mueller, Luciano, Metzler, William J, McDonnell, Patricia A, Todderud, Gordon, Goldfarb, Valentina, Fan, Yi, Newitt, John A, Kiefer, Susan E, Gao, Mian, Tortolani, David, Vaccaro, Wayne, Tokarski, John

“…Fragment-like inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK2) include 5-hydroxyisoquinoline (IC50 ∼ 85 μM). Modeling studies…”
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Synthesis and SAR of p38α MAP kinase inhibitors based on heterobicyclic scaffolds by Murali Dhar, T.G., Wrobleski, Stephen T., Lin, Shuqun, Furch, Joseph A., Nirschl, David S., Fan, Yi, Todderud, Gordon, Pitt, Sidney, Doweyko, Arthur M., Sack, John S., Mathur, Arvind, McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

“…The synthesis and structure–activity relationships (SAR) of p38α MAP kinase inhibitors based on heterobicyclic scaffolds are described. This effort led to the…”
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Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor by Todderud, Gordon, Wahl, Matthew I., Rhee, Sue Goo, Carpenter, Graham

“…Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-γ1 (PLC-γ1) from a predominantly…”
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Elevated Content of the Tyrosine Kinase Substrate Phospholipase C-γ1 in Primary Human Breast Carcinomas by Arteaga, Carlos L., Johnson, Mahlon D., Todderud, Gordon, Coffey, Robert J., Carpenter, Graham, Page, David L.

“…Phospholipase C-γ1 (PLC-γ1) is a substrate for several receptor tyrosine kinases and its catalytic activity is increased by tyrosine phosphorylation. However,…”
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Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds by Murali Dhar, T G, Wrobleski, Stephen T, Lin, Shuqun, Furch, Joseph A, Nirschl, David S, Fan, Yi, Todderud, Gordon, Pitt, Sidney, Doweyko, Arthur M, Sack, John S, Mathur, Arvind, McKinnon, Murray, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

“…The synthesis and structure-activity relationships (SAR) of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds are described. This effort led to…”
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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold by Potin, Dominique, Launay, Michele, Nicolai, Eric, Fabreguette, Maud, Malabre, Patrice, Caussade, François, Besse, Dominique, Skala, Stacey, Stetsko, Dawn K., Todderud, Gordon, Beno, Brett R., Cheney, Daniel L., Chang, Chiehying J., Sheriff, Steven, Hollenbaugh, Diane L., Barrish, Joel C., Iwanowicz, Edwin J., Suchard, Suzanne J., Dhar, T.G. Murali

“…LFA-1 is a member of the β2-integrin family and is expressed on all leukocytes. This paper describes the de novo design, synthesis, and in vitro activity of…”
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Cytosolic [Ca2+] homeostasis and tyrosine phosphorylation of phospholipase Cγ2 in HL60 granulocytes by BIANCHINI, L, TODDERUD, G, GRINSTEIN, S

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Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates by Marinier, Anne, Martel, Alain, Bachand, Carol, Plamondon, Serge, Turmel, Brigitte, Daris, Jean-Paul, Banville, Jacques, Lapointe, Philippe, Ouellet, Carl, Dextraze, Pierre, Menard, Marcel, Wright, John J.K, Alford, Julie, Lee, Debbie, Stanley, Paul, Nair, Xina, Todderud, Gordon, Tramposch, Kenneth M

“…A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a…”
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Novel mimics of sialyl Lewis X by Marinier, Anne, Martel, Alain, Bachand, Carol, Plamondon, Serge, Turmel, Brigitte, Daris, Jean-Paul, Banville, Jacques, Lapointe, Philippe, Ouellet, Carl, Dextraze, Pierre, Menard, Marcel, Wright, John J.K, Alford, Julie, Lee, Debbie, Stanley, Paul, Nair, Xina, Todderud, Gordon, Tramposch, Kenneth M

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Isolation and Structure Determination of Sulfonoquinovosyl Dipalmitoyl Glyceride, a P-Selectin Receptor Inhibitor from the Alga Dictyochloris fragrans by Golik, Jerzy, Dickey, Joyce K, Todderud, Gordon, Lee, Deborah, Alford, Julie, Huang, Stella, Klohr, Steven, Eustice, David, Aruffo, Alejandro, Agler, Michele L

“…Bioassay-guided fractionation of the marine alga Dictyochloris fragrans led to the isolation and identification of sulfonoquinovosyl dipalmitoyl glyceride (1)…”
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Sulfated Galactocerebrosides as Potential Antiinflammatory Agents by Marinier, Anne, Martel, Alain, Banville, Jacques, Bachand, Carol, Remillard, Roger, Lapointe, Philippe, Turmel, Brigitte, Menard, Marcel, Harte, William E, Wright, J. J. Kim, Todderud, Gordon, Tramposch, Kenneth M, Bajorath, Jürgen, Hollenbaugh, Diane, Aruffo, Alejandro

“…Native sulfatides, as well as many sulfated glycolipids, have been shown to avidly bind to the selectin receptors. In vivo, native sulfatides significantly…”
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Phorbol Ester-Induced Upregulation of Polymorphonuclear Leukocyte P-Selectin Ligand Expression by TODDERUD, GORDON, ALFORD, JULIE, ARUFFO, ALEJANDRO, TRAMPOSCH, KENNETH M.

“…Proinflammatory stimuli cause the vascular endothelium to express P-selectin that tethers leukocytes by binding surface glycoprotein carbohydrate. While the…”
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Stimulation of Phospholipase C-(gamma)1 Membrane Association by Epidermal Growth Factor by Todderud, Gordon, Wahl, Matthew I, Rhee, Sue Goo, Carpenter, Graham

“…Epidermal growth factor treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma1 from a predominantly cytosolic…”
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PMN binding to P-selectin is inhibited by sulfatide by Todderud, G, Alford, J, Millsap, K A, Aruffo, A, Tramposch, K M

“…The endothelial adhesion protein P-selectin binds to a ligand present on the surface of leukocytes. We have characterized the binding interaction between…”
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Stimulation of Phospholipase C-γl Membrane Association by Epidermal Growth Factor by Todderud, Gordon, Wahl, Matthew I., Rhee, Sue Goo, Carpenter, Graham

“…Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-γ1 (PLC-γ1) from a predominantly…”
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The role of carbohydrate as a post-translational modification of the receptor for epidermal growth factor by Soderquist, A M, Todderud, G, Carpenter, G

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Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: Requirement for a Giα-type G-protein by Burke, James R, Davern, Lynda B, Gregor, Kurt R, Todderud, Gordon, Alford, Julie G, Tramposch, Kenneth M

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