Search Results - "Todd Gillespie"

Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry by Khatib-Shahidi, Sheerin, Andersson, Malin, Herman, Jennifer L., Gillespie, Todd A., Caprioli, Richard M.

“…Imaging mass spectrometry (IMS) that utilizes matrix-assisted laser desorption/ionization (MALDI) technology can provide a molecular ex vivo view of resected…”
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The Disposition of Prasugrel, a Novel Thienopyridine, in Humans by FARID, Nagy A, SMITH, Richard L, GILLESPIE, Todd A, RASH, T. James, BLAIR, Patrick E, KURIHARA, Atsushi, GOLDBERG, Mark J

“…Prasugrel, a prodrug, is a novel and potent inhibitor of platelet aggregation in vivo. The metabolism of prasugrel and the elimination and pharmacokinetics of…”
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Mass spectrometry for small molecule pharmaceutical product development: A review by Gillespie, Todd A., Winger, Brian E.

“…Developing a pharmaceutical product has become increasingly difficult and expensive. With an emphasis on developing project knowledge at an earlier stage in…”
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A review of nanoelectrospray ionization applications for drug metabolism and pharmacokinetics by Wickremsinhe, Enaksha R, Singh, Gurkeerat, Ackermann, Bradley L, Gillespie, Todd A, Chaudhary, Ajai K

“…Although traditionally reserved for proteomic analysis, nanoESI has found increased use for small molecule applications related to drug…”
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Identification of Aliphatic and Aromatic Tertiary N-Oxide Functionalities in Protonated Analytes via Ion/Molecule and Dissociation Reactions in an FT-ICR Mass Spectrometer by Duan, Penggao, Fu, Mingkun, Gillespie, Todd A, Winger, Brian E, Kenttämaa, Hilkka I

“…A mass spectrometric method is presented for the identification of compounds that contain the aliphatic or aromatic N-oxide functional group. This method…”
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Identification of the Aromatic Tertiary N-Oxide Functionality in Protonated Analytes via Ion/Molecule Reactions in Mass Spectrometers by Duan, Penggao, Gillespie, Todd A, Winger, Brian E, Kenttämaa, Hilkka I

“…A mass spectrometric method is presented for the rapid identification of compounds that contain the aromatic N-oxide functional group. This method utilizes a…”
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Identification and Counting of Carbonyl and Hydroxyl Functionalities in Protonated Bifunctional Analytes by Using Solution Derivatization Prior to Mass Spectrometric Analysis Via Ion-Molecule Reactions by Somuramasami, Jayalakshmi, Winger, Brian E., Gillespie, Todd A., Kenttämaa, Hilkka I.

“…A mass spectrometric method has been developed for the identification of carbonyl and hydroxyl functional groups, as well as for counting the functional…”
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APPLICATION OF BIOCATALYSIS TO DRUG METABOLISM: PREPARATION OF MAMMALIAN METABOLITES OF A BIARYL-BIS-SULFONAMIDE AMPA (α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID) RECEPTOR POTENTIATOR USING Actinoplanes missouriensis by ZMIJEWSKI, Milton, GILLESPIE, Todd A, JACKSON, David A, SCHMIDT, Douglas F, PING YI, KULANTHAIVEL, Palaniappan

“…LY451395 (2-propanesulfonamide, N -[(2 R )-2-[4′-[2-[methylsulfonyl)amino]ethyl][1,1′-biphenyl]-4-yl]propyl]-) is a potent and highly selective potentiator…”
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Disposition and Biotransformation of the Antipsychotic Agent Olanzapine in Humans by Kelem Kassahun, Edward Mattiuz, Eldon Nyhart, Jr, Boyd Obermeyer, Todd Gillespie, Anthony Murphy, R. Michael Goodwin, David Tupper, J. Thomas Callaghan, Louis Lemberger

“…Disposition and biotransformation of the new antipsychotic agent olanzapine (OLZ) were studied in six male healthy volunteers after a single oral dose of 12.5…”
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The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor α-γ dual, γ-dominant agonist in mice, rats, and monkeys by PING YI, HADDEN, Chad E, ANNES, William F, JACKSON, David A, PETERSON, Barry C, GILLESPIE, Todd A, JOHNSON, Jason T

“…Naveglitazar [LY519818; benzenepropanoic acid, alpha-methoxy-4-[3-(4-phenoxyphenoxy)propoxy], (alpha-S)-] is a nonthiozolidinedione peroxisome…”
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Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6 by Ekins, S, Bravi, G, Ring, B J, Gillespie, T A, Gillespie, J S, Vandenbranden, M, Wrighton, S A, Wikel, J H

“…To begin to build an understanding of the interactions of CYP2B6 with substrates, two different 3-dimensional quantitative structure activity relationship…”
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Disposition and Metabolism of Olanzapine in Mice, Dogs, and Rhesus Monkeys by MATTIUZ, E, FRANKLIN, R, GILLESPIE, T, MURPHY, A, BERNSTEIN, J, CHIU, A, HOTTEN, T, KASSAHUN, K

“…Olanzapine (OLZ) is a novel antipsychotic agent with a high affinity for serotonin (5-HT 2 ), dopamine (D 1 /D 2 /D 4 ), muscarinic (m 1 –m 5 ), adrenergic…”
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The synthesis of (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine hydrochloride and its C-14-labeled isotopomer by Wheeler, William J., O'Bannon, Douglas D., Swanson, Steven, Gillespie, Todd A., Varie, David L.

“…The partial ergoline LY228729 (1) which was a potent 5HT1A agonist has been studied clinically. Somewhat later, a related analog,…”
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Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection by Catlow, John T., Barton, Richard D., Clements, Matt, Gillespie, Todd A., Goodwin, Michael, Swanson, Steven P.

“…A sensitive reversed-phase HPLC method for the analysis of olanzapine in human plasma is described. Isolation of olanzapine from plasma was accomplished by…”
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Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine by Ring, B J, Catlow, J, Lindsay, T J, Gillespie, T, Roskos, L K, Cerimele, B J, Swanson, S P, Hamman, M A, Wrighton, S A

“…The formation kinetics of 2-hydroxymethyl olanzapine (2-OH olanzapine), 4'-N-oxide olanzapine (N-O olanzapine) and 4'-N-desmethyl olanzapine (NdM olanzapine)…”
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Olanzapine 10-N-glucuronide : A tertiary N-glucuronide unique to humans by KASSAHUN, K, MATTIUZ, E, FRANKLIN, R, GILLESPIE, T

“…In humans, a major metabolite of the atypical antipsychotic olanzapine in the plasma and in the urine was found to be an N-glucuronide. Unexpectedly, the…”
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Pergolide: multiple-dose pharmacokinetics in patients with mild to moderate Parkinson disease by Thalamas, Claire, Rajman, Iris, Kulisevsky, Jaime, Lledó, Alberto, Mackie, Alison E, Blin, Olivier, Gillespie, Todd A, Seger, Mary, Rascol, Olivier

“…The primary objective of this study was to describe the pharmacokinetics of oral pergolide in patients with mild to moderate Parkinson disease using a new…”
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Determination of the muscarinic agent [(3-(3-1-butylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane], in rat, rabbit, and monkey plasma, using high-performance liquid chromatography in conjunction with tandem mass spectrometry by Cornpropst, J.David, Gillespie, Todd A., Shipley, Lisa A.

“…A method for determining a selective muscarinic agent, LY297802 (compound I), [(3-(3-1-butylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane], indicated…”
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Olanzapine 10-N-Glucuronide by Kelem Kassahun, Edward Mattiuz, Ronald Franklin, Todd Gillespie

“…In humans, a major metabolite of the atypical antipsychotic olanzapine in the plasma and in the urine was found to be an N -glucuronide. Unexpectedly, the…”
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Hot property: geometric homes by Gillespie, Todd

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