Search Results - "Todd, J. A"

Hopping Hotspots: Global Shifts in Marine Biodiversity by Renema, W., Bellwood, D. R., Braga, J. C., Bromfield, K., Hall, R., Johnson, K. G., Lunt, P., Meyer, C. P., McMonagle, L. B., Morley, R. J., O'Dea, A., Todd, J. A., Wesselingh, F. P., Wilson, M. E. J., Pandolfi, J. M.

“…Hotspots of high species diversity are a prominent feature of modern global biodiversity patterns. Fossil and molecular evidence is starting to reveal the…”
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Chikungunya virus requires cellular chloride channels for efficient genome replication by Müller, Marietta, Slivinski, Natalie, Todd, Eleanor J A A, Khalid, Henna, Li, Raymond, Karwatka, Magdalena, Merits, Andres, Mankouri, Jamel, Tuplin, Andrew

“…Chikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that is transmitted to humans by Aedes spp. mosquitoes-causing fever and debilitating joint…”
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CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets by Schofield, E C, Carver, T, Achuthan, P, Freire-Pritchett, P, Spivakov, M, Todd, J A, Burren, O S

“…Promoter capture Hi-C (PCHi-C) allows the genome-wide interrogation of physical interactions between distal DNA regulatory elements and gene promoters in…”
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Multi‐parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes by Thompson, W. S., Pekalski, M. L., Simons, H. Z., Smyth, D. J., Castro‐Dopico, X., Guo, H., Guy, C., Dunger, D. B., Arif, S., Peakman, M., Wallace, C., Wicker, L. S., Todd, J. A, Ferreira, R. C.

“…Summary The appearance of circulating islet‐specific autoantibodies before disease diagnosis is a hallmark of human type 1 diabetes (T1D), and suggests a role…”
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Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases by Howson, J. M. M., Krause, S., Stevens, H., Smyth, D. J., Wenzlau, J. M., Bonifacio, E., Hutton, J., Ziegler, A. G., Todd, J. A., Achenbach, P.

“…Aims/hypothesis Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known…”
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Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I–II of the ipsilateral spinal dorsal horn by Polgár, E, Todd, A.J

“…Abstract Although there is evidence that reduced inhibition in the spinal dorsal horn contributes to neuropathic pain, the mechanisms that underlie this are…”
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Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus by Fung, E Y M G, Smyth, D J, Howson, J M M, Cooper, J D, Walker, N M, Stevens, H, Wicker, L S, Todd, J A

“…As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to…”
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Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A by Howson, J.M.M, Walker, N.M, Clayton, D, Todd, J.A

“…Until recently, human leucocyte antigen (HLA) class II-independent associations with type 1 diabetes (T1D) in the Major Histocompatibility Complex (MHC) region…”
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A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord by Spike, R. C., Puskár, Z., Andrew, D., Todd, A. J.

“…In the rat lumbar spinal cord the major supraspinal targets for lamina I projection neurons are the caudal ventrolateral medulla (CVLM), lateral parabrachial…”
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The dragon tamed? A molecular phylogeny of the Conoidea (Gastropoda) by Puillandre, N., Kantor, Yu. I., Sysoev, A., Couloux, A., Meyer, C., Rawlings, T., Todd, J. A., Bouchet, P.

“…The superfamily Conoidea constitutes one of the most diverse and taxonomically challenging groups among marine molluscs. Classifications based on shell or…”
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Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain by Polgár, E, Hughes, D.I, Riddell, J.S, Maxwell, D.J, Puskár, Z, Todd, A.J

“…GABA and glycine are inhibitory neurotransmitters used by many neurons in the spinal dorsal horn, and intrathecal administration of GABA A and glycine receptor…”
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Lack of evidence for significant neuronal loss in laminae I–III of the spinal dorsal horn of the rat in the chronic constriction injury model by Polgár, E., Gray, S., Riddell, J.S., Todd, A.J.

“…Peripheral nerve injury leads to structural and functional changes in the spinal dorsal horn, and these are thought to be involved in the development of…”
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The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn by Todd, A. J., Hughes, D. I., Polgár, E., Nagy, G. G., Mackie, M., Ottersen, O. P., Maxwell, D. J.

“…Two vesicular glutamate transporters, VGLUT1 and VGLUT2, have recently been identified, and it has been reported that they are expressed by largely…”
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A quantitative study of neuronal nitric oxide synthase expression in laminae I–III of the rat spinal dorsal horn by Sardella, T.C.P, Polgár, E, Watanabe, M, Todd, A.J

“…Abstract Nitric oxide produced by neuronal nitric oxide synthase (nNOS) in the spinal cord is required for development of hyperalgesia in inflammatory and…”
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HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB103 haplotype by Howson, J. M. M., Roy, M. S., Zeitels, L., Stevens, H., Todd, J. A.

“…Aims Owing to strong linkage disequilibrium between markers, pinpointing disease associations within genetic regions is difficult in European ancestral…”
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Electrophysiological and morphological characterization of propriospinal interneurons in the thoracic spinal cord by Saywell, S A, Ford, T W, Meehan, C F, Todd, A J, Kirkwood, P A

“…Propriospinal interneurons in the thoracic spinal cord have vital roles not only in controlling respiratory and trunk muscles, but also in providing possible…”
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Anatomy of primary afferents and projection neurones in the rat spinal dorsal horn with particular emphasis on substance P and the neurokinin 1 receptor by Todd, A. J.

“…The dorsal horn of the spinal cord plays an important role in transmitting information from nociceptive primary afferent neurones to the brain; however, our…”
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No association of multiple type 2 diabetes loci with type 1 diabetes by Raj, S. M, Howson, J. M. M, Walker, N. M, Cooper, J. D, Smyth, D. J, Field, S. F, Stevens, H. E, Todd, J. A

“…Aims/hypothesis We used recently confirmed type 2 diabetes gene regions to investigate the genetic relationship between type 1 and type 2 diabetes, in an…”
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β‐cell specific T‐lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults by Arif, S., Gibson, V. B., Nguyen, V., Bingley, P. J., Todd, J. A., Guy, C., Dunger, D. B., Dayan, C. M., Powrie, J., Lorenc, A., Peakman, M.

“…Aim To examine the hypothesis that the quality, magnitude and breadth of helper T‐lymphocyte responses to β cells differ in Type 1 diabetes according to…”
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Strategies for the prevention of autoimmune Type 1 diabetes by Todd, J. A., Knip, M., Mathieu, C.

“…Diabet. Med. 28, 1141–1143 (2011) European experts on autoimmune Type 1 diabetes met for 2 days in October 2010 in Cambridge, to review the state‐of‐the‐art…”
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