OCCURRENCE OF HEPATOCELLULAR CARCINOMA IN AN ADULT MALE NILE LECHWE (KOBUS MEGACEROS)

OCCURRENCE OF HEPATOCELLULAR CARCINOMA IN AN ADULT MALE NILE LECHWE (KOBUS MEGACEROS)

A 14-yr-old male Nile lechwe (Kobus megaceros) from the Jackson Zoo (Mississippi, USA) had chronic weight loss that was associated with elevated serum alkaline phosphatase levels. Approximately 4 yr after the first clinical signs of weight loss, the animal fractured its left rear femur and was subse...

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Bibliographic Details
Published in:Journal of zoo and wildlife medicine Vol. 38; no. 2; pp. 329 - 332
Main Authors: Wilson, Floyd D, Fitzgerald, Scott D, Kiupel, Matti, Walker, Rodney L, Williams, Corey B, Todd, Donna J
Format: Journal Article
Language:English
Published: United States American Association of Zoo Veterinarians 01-06-2007
Subjects:
Animals
Animals, Zoo
Antelope
Antelopes
Bile ducts
Brief Communication
Brief Communications
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - veterinary
Fatal Outcome
Femoral fractures
Hepatocellular carcinoma
Hepatocytes
Kobus megaceros
Liver
Liver Neoplasms - epidemiology
Liver Neoplasms - pathology
Liver Neoplasms - veterinary
Lungs
Male
Neoplasia
Nile lechwe
Tumors
Zoos
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Summary:A 14-yr-old male Nile lechwe (Kobus megaceros) from the Jackson Zoo (Mississippi, USA) had chronic weight loss that was associated with elevated serum alkaline phosphatase levels. Approximately 4 yr after the first clinical signs of weight loss, the animal fractured its left rear femur and was subsequently euthanized; on the same day necropsy was performed. The liver was grossly enlarged and contained a smooth-surfaced nodular mass that occupied the majority of the right lobe of the liver. The mass had a liver-like appearance exhibiting a tan–red coloration but having a soft consistency. A single, approximately 0.6 cm, round, slightly elevated discrete red nodule was present in the left anterior lung. Microscopically, the hepatic mass and pulmonary nodule diffusely consisted of irregular cords of cells exhibiting hepatoid features, but containing no evidence of normal portal bile duct or portal triad development. To our knowledge, this is the first report in the scientific literature of a naturally occurring case of hepatocellular carcinoma in a Nile lechwe or in any antelope species.
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ISSN:1042-7260
1937-2825
DOI:10.1638/1042-7260(2007)038[0329:OOHCIA]2.0.CO;2