Search Results - "Todaro, Dustin R."

Medial prefrontal neuroplasticity during extended-release naltrexone treatment of opioid use disorder – a longitudinal structural magnetic resonance imaging study by Shi, Zhenhao, Li, Xinyi, Todaro, Dustin R., Cao, Wen, Lynch, Kevin G., Detre, John A., Loughead, James, Langleben, Daniel D., Wiers, Corinde E.

“…Opioid use disorder (OUD) has been linked to macroscopic structural alterations in the brain. The monthly injectable, extended-release formulation of μ-opioid…”
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Collateral Damage: Neurological Correlates of Non-Fatal Overdose in the Era of Fentanyl-Xylazine by Todaro, Dustin R, Volkow, Nora D, Langleben, Daniel D, Shi, Zhenhao, Wiers, Corinde E

“…Non-fatal opioid overdoses are associated with significant morbidity. Hypoxic brain injury caused by opioid-induced respiratory depression is a key mechanism…”
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Convergent Evolution in the Assembly of Polyubiquitin Degradation Signals by the Shigella flexneri IpaH9.8 Ligase by Edwards, Daniel J., Streich, Frederick C., Ronchi, Virginia P., Todaro, Dustin R., Haas, Arthur L.

“…The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohort of effector proteins via a type III secretion system. The IpaH…”
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Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease by Kiprowska, Magdalena J., Stepanova, Anna, Todaro, Dustin R., Galkin, Alexander, Haas, Arthur, Wilson, Scott M., Figueiredo-Pereira, Maria E.

“…In Alzheimer's disease proteasome activity is reportedly downregulated, thus increasing it could be therapeutically beneficial. The proteasome-associated…”
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Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly by Todaro, Dustin R., Augustus-Wallace, Allison C., Klein, Jennifer M., Haas, Arthur L.

“…The NEDD4-2 (neural precursor cell–expressed developmentally down-regulated 4-2) HECT ligase catalyzes polyubiquitin chain assembly by an ordered two-step…”
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The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly by Todaro, Dustin R., Augustus-Wallace, Allison C., Klein, Jennifer M., Haas, Arthur L.

“…The mechanism of Nedd4-2 has been quantitatively explored for the first time using biochemically defined kinetic assays examining rates of 125I-polyubiquitin…”
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Methadone Dosing for Opioid Use Disorder in the Setting of Infective Endocarditis and QTc Prolongation by Todaro, Dustin R, Hoffman, Kevin W, Zwiebel, Samantha J

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Ketone Supplementation Dampens Subjective and Objective Responses to Alcohol: Evidence From a Preclinical Rat Study and a Randomized, Cross-Over Trial in Healthy Volunteers by Li, Xinyi, Shi, Zhenhao, Todaro, Dustin R, Pond, Timothy, Byanyima, Juliana I, Vesslee, Sianneh A, Reddy, Rishika, Nanga, Ravi Prakash Reddy, Kass, Gabriel, Ramchandani, Vijay, Kranzler, Henry R, Vendruscolo, Janaina C M, Vendruscolo, Leandro F, Wiers, Corinde E

“…Abstract Background Previous preclinical and human studies have shown that a high-fat ketogenic diet and ketone supplements (KS) are efficacious in reducing…”
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Hippocampal volume loss in individuals with a history of non-fatal opioid overdose by Todaro, Dustin R, Li, Xinyi, Pereira-Rufino, Laís S, Manza, Peter, Nasrallah, Ilya M, Das, Sandhitsu, Childress, Anna Rose, Kranzler, Henry R, Volkow, Nora D, Langleben, Daniel D, Shi, Zhenhao, Wiers, Corinde E

“…Incidence of opioid-related overdoses in the United States has increased dramatically over the past two decades. Despite public emphasis on overdose…”
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(175) Safety of Rapid Methadone Titration for Opioid Use Disorder in Hospitalized Patients: A Pilot Study by Todaro, Dustin R., Casey, Emily, Thakrar, Ashish P., Uritsky, Tanya J., Zwiebel, Samantha

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Nedd4-2 is a Functional Oligomer Exhibiting Cooperative Allosteric Kinetics by Todaro, Dustin R., Augustus-Wallace, Allison C., Klein, Jennifer M., Haas, Arthur L.

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Mechanistic Conservation in Nedd4-2/Nedd4L-Catalyzed Polyubiquitin Chain Assembly by Todaro, Dustin R

“…The Hect ligases constitute a relatively small superfamily of ubiquitin conjugating enzymes but are disproportionately represented in a variety of diseases,…”
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