Search Results - "Tod, Julie"

Structural studies suggest aggregation as one of the modes of action for teixobactin by Öster, Carl, Walkowiak, Grzegorz P, Hughes, Dallas E, Spoering, Amy L, Peoples, Aaron J, Catherwood, Anita C, Tod, Julie A, Lloyd, Adrian J, Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G, Lewandowski, Józef R

“…Teixobactin is a new promising antibiotic that targets cell wall biosynthesis by binding to lipid II and has no detectable resistance thanks to its unique but…”
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Substrate and Stereochemical Control of Peptidoglycan Cross-Linking by Transpeptidation by Escherichia coli PBP1B by Catherwood, Anita C, Lloyd, Adrian J, Tod, Julie A, Chauhan, Smita, Slade, Susan E, Walkowiak, Grzegorz P, Galley, Nicola F, Punekar, Avinash S, Smart, Katie, Rea, Dean, Evans, Neil D, Chappell, Michael J, Roper, David I, Dowson, Christopher G

“…Penicillin binding proteins (PBPs) catalyzing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets…”
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Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis by Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J.

“…Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for…”
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Glutamate racemase is a compelling target for antibiotic design for the treatment of infections caused by Pseudomonas aeruginosa by Pooreidy, Bahram, Campbell, Ashley, Lloyd, Adrian, Tod, Julie, Dowson, Christopher, Martin, Lois W., Lamont, Iain, Krause, Kurt L.

“…Abstract only…”
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In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB by Hrast, Martina, Jukič, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, Hélène, Gobec, Stanislav

“…In the context of antibacterial drug discovery resurgence, novel therapeutic targets and new compounds with alternative mechanisms of action are of paramount…”
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Structural studies suggest aggregation as one of the modes of action for teixobactinElectronic supplementary information (ESI) available: Additional figures. NMR titration data. FRET assays. NMR spectra. NMR relaxation data. PDB of the structure of teixobactin in DPC micelles. See DOI: 10.1039/c8sc03655a by Öster, Carl, Walkowiak, Grzegorz P, Hughes, Dallas E, Spoering, Amy L, Peoples, Aaron J, Catherwood, Anita C, Tod, Julie A, Lloyd, Adrian J, Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G, Lewandowski, Józef R

“…Teixobactin is a new promising antibiotic that targets cell wall biosynthesis by binding to lipid II and has no detectable resistance thanks to its unique but…”
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Structural studies suggest aggregation as one of the modes of action for teixobactin† †Electronic supplementary information (ESI) available: Additional figures. NMR titration data. FRET assays. NMR spectra. NMR relaxation data. PDB of the structure of teixobactin in DPC micelles. See DOI: 10.1039/c8sc03655a by Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R.

“…Combination of solution and solid state NMR yields a molecular level view of the interactions between antibiotic teixobactin and bacterial cell wall building…”
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