Search Results - "Toczko, Matthew A"

Development of a New Synthesis for the Large-Scale Preparation of Triple Reuptake Inhibitor (−)-GSK1360707 by Elitzin, Vassil I, Harvey, Kimberly A, Kim, Hyunjung, Salmons, Matthew, Sharp, Matthew J, Tabet, Elie A, Toczko, Matthew A

“…The triple reuptake inhibitor, GSK1360707, was synthesized via an efficient, scalable route, which features a vinyl triflate Suzuki coupling followed by a…”
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Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers by Dunn, Anna L, Leitch, David C, Journet, Michel, Martin, Michael, Tabet, Elie A, Curtis, Neil R, Williams, Glynn, Goss, Charles, Shaw, Tony, O’Hare, Bernie, Wade, Charles, Toczko, Matthew A, Liu, Peng

“…The iodination of 4-fluoro-2-(trifluoromethyl)­benzonitrile via C–H lithiation and subsequent treatment with iodine under continuous flow conditions is…”
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Synthesis of HCV Replicase Inhibitors: Base-Catalyzed Synthesis of Protected α‑Hydrazino Esters and Selective Aerobic Oxidation with Catalytic Pt/Bi/C for Synthesis of Imidazole-4,5-dicarbaldehyde by Bowman, Roy K, Brown, Andrew D, Cobb, Jannine H, Eaddy, John F, Hatcher, Mark A, Leivers, Martin R, Miller, John F, Mitchell, Mark B, Patterson, Daniel E, Toczko, Matthew A, Xie, Shiping

“…A robust convergent synthesis of the prodrugs of HCV replicase inhibitors 1–5 is described. The central 5H-imidazo[4,5-d]pyridazine core was formed from…”
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Total Synthesis of (±)-Aspidospermidine by Toczko, Matthew A, Heathcock, Clayton H

“…(±)-Aspidospermidine (1) has been synthesized from readily available methyl 3-ethyl-2-oxocylopentanecarboxylate (17) in 5.9% yield over 13 steps. The key step…”
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A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate by Boros, Eric E, Burova, Svetlana A, Erickson, Greg A, Johns, Brian A, Koble, Cecilia S, Kurose, Noriyuki, Sharp, Matthew J, Tabet, Elie A, Thompson, James B, Toczko, Matthew A

“…A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde…”
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