Search Results - "Tochio, Hidehito"

Watching protein structure at work in living cells using NMR spectroscopy by Tochio, Hidehito

“…► Advances in in-cell NMR spectroscopy of biomacromolecules. ► Escherichia coli, yeasts, Xenopus laevis oocytes and mammalian cell lines can be used. ►…”
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Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism by Ariyoshi, Mariko, Shirakawa, Masahiro, Arita, Kyohei, Tochio, Hidehito, Nakamura, Yusuke

“…DNA methylation of CpG dinucleotides is an important epigenetic modification of mammalian genomes and is essential for the regulation of chromatin structure,…”
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Real-Time Background-Free Selective Imaging of Fluorescent Nanodiamonds in Vivo by Igarashi, Ryuji, Yoshinari, Yohsuke, Yokota, Hiroaki, Sugi, Takuma, Sugihara, Fuminori, Ikeda, Kazuhiro, Sumiya, Hitoshi, Tsuji, Shigenori, Mori, Ikue, Tochio, Hidehito, Harada, Yoshie, Shirakawa, Masahiro

“…Recent developments of imaging techniques have enabled fluorescence microscopy to investigate the localization and dynamics of intracellular substances of…”
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Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 by Arita, Kyohei, Isogai, Shin, Oda, Takashi, Unoki, Motoko, Sugita, Kazuya, Sekiyama, Naotaka, Kuwata, Keiko, Hamamoto, Ryuji, Tochio, Hidehito, Sato, Mamoru, Ariyoshi, Mariko, Shirakawa, Masahiro

“…Multiple covalent modifications on a histone tail are often recognized by linked histone reader modules. UHRF1 [ubiquitin-like, containing plant homeodomain…”
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The structural basis for receptor recognition of human interleukin-18 by Tsutsumi, Naotaka, Kimura, Takeshi, Arita, Kyohei, Ariyoshi, Mariko, Ohnishi, Hidenori, Yamamoto, Takahiro, Zuo, Xiaobing, Maenaka, Katsumi, Park, Enoch Y., Kondo, Naomi, Shirakawa, Masahiro, Tochio, Hidehito, Kato, Zenichiro

“…Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this…”
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Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization by Fujita, Hiroaki, Tokunaga, Akira, Shimizu, Satoshi, Whiting, Amanda L., Aguilar-Alonso, Francisco, Takagi, Kenji, Walinda, Erik, Sasaki, Yoshiteru, Shimokawa, Taketo, Mizushima, Tsunehiro, Ohki, Izuru, Ariyoshi, Mariko, Tochio, Hidehito, Bernal, Federico, Shirakawa, Masahiro, Iwai, Kazuhiro

“…The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target…”
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A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation by Muraoka, Takahiro, Adachi, Kota, Ui, Mihoko, Kawasaki, Shunichi, Sadhukhan, Nabanita, Obara, Haruki, Tochio, Hidehito, Shirakawa, Masahiro, Kinbara, Kazushi

“…Part of the solution: A PEG with a discrete triangular structure exhibits hydrophilicity/hydrophobicity switching upon increasing temperatures, and suppresses…”
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Structural Basis for the Multiple Interactions of the MyD88 TIR Domain in TLR4 Signaling by Ohnishi, Hidenori, Tochio, Hidehito, Kato, Zenichiro, Orii, Kenji E., Li, Ailian, Kimura, Takeshi, Hiroaki, Hidekazu, Kondo, Naomi, Shirakawa, Masahiro, Strominger, Jack L.

“…Myeloid differentiating factor 88 (MyD88) and MyD88 adaptor-like (Mal) are adaptor molecules critically involved in the Toll-like receptor (TLR) 4 signaling…”
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Pruning the ALS-Associated Protein SOD1 for in-Cell NMR by Danielsson, Jens, Inomata, Kohsuke, Murayama, Shuhei, Tochio, Hidehito, Lang, Lisa, Shirakawa, Masahiro, Oliveberg, Mikael

“…To efficiently deliver isotope-labeled proteins into mammalian cells poses a main challenge for structural and functional analysis by in-cell NMR. In this…”
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Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes by Polat, Onur K., Uno, Masatoshi, Maruyama, Terukazu, Tran, Ha Nam, Imamura, Kayo, Wong, Chee Fah, Sakaguchi, Reiko, Ariyoshi, Mariko, Itsuki, Kyohei, Ichikawa, Jun, Morii, Takashi, Shirakawa, Masahiro, Inoue, Ryuji, Asanuma, Katsuhiko, Reiser, Jochen, Tochio, Hidehito, Mori, Yasuo, Mori, Masayuki X.

“…Significance Statement TRPC6 is a receptor-activated nonselective cation channel. Naturally occurring mutations in this channel are associated with FSGS…”
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Characterizing conformational ensembles of multi-domain proteins using anisotropic paramagnetic NMR restraints by Hou, Xue-Ni, Tochio, Hidehito

“…It has been over two decades since paramagnetic NMR started to form part of the essential techniques for structural analysis of proteins under physiological…”
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Suppression of Nonspecific Protein–Nanodiamond Adsorption Enabling Specific Targeting of Nanodiamonds to Biomolecules of Interest by Sotoma, Shingo, Igarashi, Ryuji, Iimura, Jun, Kumiya, Yuta, Tochio, Hidehito, Harada, Yoshie, Shirakawa, Masahiro

“…Applications of nanodiamonds (NDs) to bioimaging are restricted because of the nonspecific adsorption of biomolecules on the surface of NDs. Here, we show that…”
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An innate interaction between IL-18 and the propeptide that inactivates its precursor form by Tsutsumi, Naotaka, Yokota, Ayumi, Kimura, Takeshi, Kato, Zenichiro, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito

“…Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic…”
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Crystal structure of thymine DNA glycosylase conjugated to SUMO-1 by Shirakawa, Masahiro, Hiroaki, Hidekazu, Sugasawa, Kaoru, Maita, Nobuo, Tochio, Hidehito, Uchimura, Yasuhiro, Hanaoka, Fumio, Jee, Jun-Goo, Saitoh, Hisato, Baba, Daichi

“…Members of the small ubiquitin-like modifier (SUMO) family can be covalently attached to the lysine residue of a target protein through an enzymatic pathway…”
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Structure of the Small Ubiquitin-like Modifier (SUMO)-interacting Motif of MBD1-containing Chromatin-associated Factor 1 Bound to SUMO-3 by Sekiyama, Naotaka, Ikegami, Takahisa, Yamane, Tsutomu, Ikeguchi, Mitsunori, Uchimura, Yasuhiro, Baba, Daichi, Ariyoshi, Mariko, Tochio, Hidehito, Saitoh, Hisato, Shirakawa, Masahiro

“…Post-translational modification by small ubiquitin-like modifier (SUMO) proteins has been implicated in the regulation of a variety of cellular events. The…”
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UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion by Hirasaka, Katsuya, Mills, Edward M., Haruna, Marie, Bando, Aki, Ikeda, Chika, Abe, Tomoki, Kohno, Shohei, Nowinski, Sara M., Lago, Cory U., Akagi, Ken-ichi, Tochio, Hidehito, Ohno, Ayako, Teshima-Kondo, Shigetada, Okumura, Yuushi, Nikawa, Takeshi

“…Uncoupling protein 3 (UCP3) is known to regulate energy dissipation, proton leakage, fatty acid oxidation, and oxidative stress. To identify the putative…”
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Intracellular Phosphate Serves as a Signal for the Regulation of the PHO Pathway in Saccharomyces cerevisiae by Auesukaree, Choowong, Homma, Tomoyuki, Tochio, Hidehito, Shirakawa, Masahiro, Kaneko, Yoshinobu, Harashima, Satoshi

“…In Saccharomyces cerevisiae, the phosphate signal transduction pathway (PHO pathway) is known to regulate the expression of several phosphate-responsive genes,…”
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TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88 by Ohnishi, Hidenori, Tochio, Hidehito, Kato, Zenichiro, Kawamoto, Norio, Kimura, Takeshi, Kubota, Kazuo, Yamamoto, Takahiro, Funasaka, Tatsuyoshi, Nakano, Hiroshi, Wong, Richard W, Shirakawa, Masahiro, Kondo, Naomi

“…MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18…”
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Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and 19F Magnetic Resonance Imaging by Higashino, Tomohiro, Nakatsuji, Hirotaka, Fukuda, Ryosuke, Okamoto, Haruki, Imai, Hirohiko, Matsuda, Tetsuya, Tochio, Hidehito, Shirakawa, Masahiro, Tkachenko, Nikolai V., Hashida, Mitsuru, Murakami, Tatsuya, Imahori, Hiroshi

“…Two features of meso‐Aryl‐substituted expanded porphyrins suggest suitability as theranostic agents. They have excellent absorption in near infrared (NIR)…”
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Plc1p, Arg82p, and Kcs1p, Enzymes Involved in Inositol Pyrophosphate Synthesis, Are Essential for Phosphate Regulation and Polyphosphate Accumulation in Saccharomyces cerevisiae by Auesukaree, Choowong, Tochio, Hidehito, Shirakawa, Masahiro, Kaneko, Yoshinobu, Harashima, Satoshi

“…In Saccharomyces cerevisiae, the phosphate signal transduction PHO pathway is involved in regulating several phosphate-responsive genes such as PHO5, which…”
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