Search Results - "Tocheva, Anna S"

A novel mouse model for checkpoint inhibitor-induced adverse events by Adam, Kieran, Iuga, Alina, Tocheva, Anna S, Mor, Adam

“…Immune checkpoint inhibitors have demonstrated significant efficacy in the treatment of a variety of cancers, however their therapeutic potential is limited by…”
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Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor by Peled, Michael, Tocheva, Anna S., Sandigursky, Sabina, Nayak, Shruti, Philips, Elliot A., Nichols, Kim E., Strazza, Marianne, Azoulay-Alfaguter, Inbar, Askenazi, Manor, Neel, Benjamin G., Pelzek, Adam J., Ueberheide, Beatrix, Mor, Adam

“…Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies targeting PD-1 elicit durable clinical responses in patients with…”
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SLAMF6 clustering is required to augment T cell activation by Dragovich, Matthew A, Adam, Kieran, Strazza, Marianne, Tocheva, Anna S, Peled, Michael, Mor, Adam

“…The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors that are expressed exclusively on hematopoietic cells. Most…”
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Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36 by Cooper, Grace E, Pounce, Zoe C, Wallington, Joshua C, Bastidas-Legarda, Leidy Y, Nicholas, Ben, Chidomere, Chiamaka, Robinson, Emily C, Martin, Kirstin, Tocheva, Anna S, Christodoulides, Myron, Djukanovic, Ratko, Wilkinson, Tom M A, Staples, Karl J

“…Macrophages are essential to maintaining lung homoeostasis and recent work has demonstrated that influenza-infected lung macrophages downregulate their…”
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PD-1-stimulated T cell subsets are transcriptionally and functionally distinct by Lerrer, Shalom, Tocheva, Anna S., Bukhari, Shoiab, Adam, Kieran, Mor, Adam

“…Despite the obvious inhibitory outcome of PD-1 signaling, an additional series of functions are activated. We have observed that T cells stimulated through the…”
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Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells by Mansour, Salah, Tocheva, Anna S., Cave-Ayland, Chris, Machelett, Moritz M., Sander, Barbara, Lissin, Nikolai M., Molloy, Peter E., Baird, Mark S., Stübs, Gunthard, Schröder, Nicolas W. J., Schumann, Ralf R., Rademann, Jörg, Postle, Anthony D., Jakobsen, Bent K., Marshall, Ben G., Gosain, Rajendra, Elkington, Paul T., Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Tews, Ivo, Gadola, Stephan D.

“…Cluster of differentiation 1c (CD1c)-dependent self-reactive T cells are abundant in human blood, but self-antigens presented by CD1c to the T-cell receptors…”
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Induction of Type 2 Responses by Schistosome Worms during Prepatent Infection by de Oliveira Fraga, Lucia Alves, Torrero, Marina N., Tocheva, Anna S., Mitre, Edward, Davies, Stephen J.

“…During natural schistosome infection, the induction of T helper type 2 (Th2) responses has been ascribed to parasite eggs, because exposure of the host to this…”
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Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome by Breen, Michael S., Fan, Xuanjia, Levy, Tess, Pollak, Rebecca M., Collins, Brett, Osman, Aya, Tocheva, Anna S., Sahin, Mustafa, Berry-Kravis, Elizabeth, Soorya, Latha, Thurm, Audrey, Powell, Craig M., Bernstein, Jonathan A., Kolevzon, Alexander, Buxbaum, Joseph D., Warfield, Simon K., Scherrer, Benoit, Filip-Dhima, Rajna, Dies, Kira, Siper, Paige, Hanson, Ellen, Phillips, Jennifer M.

“…Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused at least in part by haploinsufficiency of the SHANK3 gene, due to sequence variants…”
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Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine by Loman, Nicholas J, Gladstone, Rebecca A, Constantinidou, Chrystala, Tocheva, Anna S, Jefferies, Johanna M C, Faust, Saul N, O'Connor, Leigh, Chan, Jacqueline, Pallen, Mark J, Clarke, Stuart C

“…Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against…”
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Increase in serotype 6C pneumococcal carriage, United Kingdom by Tocheva, Anna S, Jefferies, Johanna M C, Christodoulides, Myron, Faust, Saul N, Clarke, Stuart C

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The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals by Philips, Elliot A., Garcia-España, Antonio, Tocheva, Anna S., Ahearn, Ian M., Adam, Kieran R., Pan, Ruimin, Mor, Adam, Kong, Xiang-Peng

“…Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is critical for modulating adaptive immunity. As such, it has been…”
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PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature by Strazza, Marianne, Bukhari, Shoiab, Tocheva, Anna S., Mor, Adam

“…Summary Ligation of the inhibitory receptor PD‐1 on T cells results in the inhibition of numerous cellular functions. Despite the overtly inhibitory outcome of…”
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Checkpoint Inhibitors: Applications for Autoimmunity by Tocheva, Anna S., Mor, Adam

“…To limit excessive T cell-mediated inflammatory responses, the immune system has a milieu of inhibitory receptors, called immune checkpoints. Cancer cells have…”
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VRK2 inhibition synergizes with PD-1 blockade to improve T cell responses by Peled, Michael, Tocheva, Anna S., Adam, Kieran, Mor, Adam

“…•VRK2 inhibition synergizes with PD-1 blockade to improve T cell responses.•Vaccinia related kinase 2 (VRK2) is a novel downstream effector of program cell…”
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Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction by Gladstone, Rebecca A, Jefferies, Johanna M, Tocheva, Anna S, Beard, Kate R, Garley, David, Chong, Wei Wei, Bentley, Stephen D, Faust, Saul N, Clarke, Stuart C

“…Highlights • PCV7 serotype replacement was near complete 5 years after PCV7 introduction. • The carriage rate remained stable through out the 5 year period. •…”
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Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions by Tocheva, Anna S., Peled, Michael, Strazza, Marianne, Adam, Kieran R., Lerrer, Shalom, Nayak, Shruti, Azoulay-Alfaguter, Inbar, Foster, Connor J.R., Philips, Elliot A., Neel, Benjamin G., Ueberheide, Beatrix, Mor, Adam

“…Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these…”
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The Common γ Chain Cytokines Interleukin (IL)–2 and IL-7 Indirectly Modulate Blood Fluke Development via Effects on CD4+ T Cells by Blank, Rebecca B., Lamb, Erika W., Tocheva, Anna S., Crow, Emily T., Lim, K. C., McKerrow, James H., Davies, Stephen J.

“…The human pathogen Schistosoma mansoni exhibits a highly evolved and intricate relationship with its host, evading immune destruction while co-opting CD4+ T…”
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EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity by Peled, Michael, Dragovich, Matthew A, Adam, Kieran, Strazza, Marianne, Tocheva, Anna S, Vega, Irving E, Mor, Adam

“…Programmed cell death 1 (PD-1) is a major coinhibitory receptor and a member of the immunological synapse (IS). To uncover proteins that regulate PD-1…”
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CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains by Chancellor, Andrew, Tocheva, Anna S., Cave-Ayland, Chris, Tezera, Liku, White, Andrew, Dulayymi, Juma’a R. Al, Bridgeman, John S., Tews, Ivo, Wilson, Susan, Lissin, Nikolai M., Tebruegge, Marc, Marshall, Ben, Sharpe, Sally, Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Baird, Mark S., Gadola, Stephan, Elkington, Paul, Mansour, Salah

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are…”
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Current methods for capsular typing of Streptococcus pneumoniae by Jauneikaite, Elita, Tocheva, Anna S., Jefferies, Johanna M.C., Gladstone, Rebecca A., Faust, Saul N., Christodoulides, Myron, Hibberd, Martin L., Clarke, Stuart C.

“…Streptococcus pneumoniae is a major respiratory tract pathogen causing pneumococcal disease mainly in children aged less than five years and in the elderly…”
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