Search Results - "Tocci, Piera"

YAP and endothelin-1 signaling: an emerging alliance in cancer by Tocci, Piera, Blandino, Giovanni, Bagnato, Anna

“…The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts…”
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β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer by Tocci, Piera, Cianfrocca, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sacconi, Andrea, Donzelli, Sara, Bonfiglio, Silvia, Bucci, Gabriele, Vizza, Enrico, Ferrandina, Gabriella, Scambia, Giovanni, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna

“…The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to…”
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Targeting Endothelin-1 Receptor/β-Arrestin-1 Axis in Ovarian Cancer: From Basic Research to a Therapeutic Approach by Tocci, Piera, Rosanò, Laura, Bagnato, Anna

“…Recent studies imply a key role of endothelin-1 receptor (ET-1R), belonging to the largest family of G protein-coupled receptors (GPCR), in the regulation of a…”
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Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer by Sestito, Rosanna, Tocci, Piera, Roman, Celia, Di Castro, Valeriana, Bagnato, Anna

“…Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous…”
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Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition by Tocci, Piera, Roman, Celia, Sestito, Rosanna, Di Castro, Valeriana, Sacconi, Andrea, Molineris, Ivan, Paolini, Francesca, Carosi, Mariantonia, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna

“…PARP inhibitors (PARPi) have changed the treatment paradigm of high-grade serous ovarian cancer (HG-SOC). However, the impact of this class of inhibitors in…”
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Macitentan blocks endothelin-1 receptor activation required for chemoresistant ovarian cancer cell plasticity and metastasis by Sestito, Rosanna, Cianfrocca, Roberta, Rosanò, Laura, Tocci, Piera, Di Castro, Valeriana, Caprara, Valentina, Bagnato, Anna

“…In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) and ET-1/ETBR signaling is linked to many tumor promoting…”
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Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer by Sestito, Rosanna, Cianfrocca, Roberta, Tocci, Piera, Rosanò, Laura, Sacconi, Andrea, Blandino, Giovanni, Bagnato, Anna

“…Identification of regulatory mechanisms underlying the poor prognosis of ovarian cancer is necessary for diagnostic and therapeutic implications. Here we show…”
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YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer by Tocci, Piera, Caprara, Valentina, Roman, Celia, Sestito, Rosanna, Rosanò, Laura, Bagnato, Anna

“…The high-grade serous ovarian cancer (HG-SOC) is a notoriously challenging disease, characterized by a rapid peritoneal dissemination. HG-SOC cells leverage…”
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The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer by Tocci, Piera, Roman, Celia, Sestito, Rosanna, Caprara, Valentina, Sacconi, Andrea, Molineris, Ivan, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna

“…The high-grade serous ovarian cancer (HG-SOC) tumor microenvironment (TME) is constellated by cellular elements and a network of soluble constituents that…”
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Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer by Cianfrocca, Roberta, Rosanò, Laura, Tocci, Piera, Sestito, Rosanna, Caprara, Valentina, Di Castro, Valeriana, De Maria, Ruggero, Bagnato, Anna

“…The limited clinical response to conventional chemotherapeutics observed in colorectal cancer (CRC) may be related to the connections between the…”
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Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer by Tocci, Piera, Cianfrocca, Roberta, Sestito, Rosanna, Rosanò, Laura, Di Castro, Valeriana, Blandino, Giovanni, Bagnato, Anna

“…The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially…”
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Endothelin A receptor/β-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy by Rosanò, Laura, Cianfrocca, Roberta, Tocci, Piera, Spinella, Francesca, Di Castro, Valeriana, Caprara, Valentina, Semprucci, Elisa, Ferrandina, Gabriella, Natali, Pier Giorgio, Bagnato, Anna

“…The high mortality of epithelial ovarian cancer (EOC) is mainly caused by resistance to the available therapies. In EOC, the endothelin-1 (ET-1,…”
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β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells by Cianfrocca, Roberta, Tocci, Piera, Semprucci, Elisa, Spinella, Francesca, Di Castro, Valeriana, Bagnato, Anna, Rosanò, Laura

“…In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such…”
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Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis by Shapiro, Beny, Tocci, Piera, Haase, Gal, Gavert, Nancy, Ben-Ze'ev, Avri

“…Hyperactive Wnt signaling is a common feature in human colorectal cancer (CRC) cells. A central question is the identification and role of Wnt/β-catenin target…”
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hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process by Di Modugno, Francesca, Caprara, Valentina, Chellini, Lidia, Tocci, Piera, Spadaro, Francesca, Ferrandina, Gabriella, Sacconi, Andrea, Blandino, Giovanni, Nisticò, Paola, Bagnato, Anna, Rosanò, Laura

“…Aberrant activation of endothelin-1 receptors (ET-1R) elicits pleiotropic effects relevant for tumor progression. The network activated by this receptor might…”
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miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma by Sestito, Rosanna, Cianfrocca, Roberta, Rosanò, Laura, Tocci, Piera, Semprucci, Elisa, Di Castro, Valeriana, Caprara, Valentina, Ferrandina, Gabriella, Sacconi, Andrea, Blandino, Giovanni, Bagnato, Anna

“…Drug resistance remains the major clinical barrier to successful treatment in epithelial ovarian carcinoma (EOC) patients, and the evidence of microRNA…”
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Abstract 1197: Endothelin-1 receptor/β-arrestin1 is an actionable node that regulates YAP/TAZ signaling and chemoresistance in high-grade ovarian cancer by Tocci, Piera, Cianfrocca, Roberta, Rosanò, Laura, Sestito, Rosanna, Castro, Valeriana Di, Blandino, Giovanni, Bagnato, Anna

“…Abstract The widespread activation of YAP and TAZ transcriptional regulators has been shown to promote tumor progression and resistance to anti-cancer…”
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Endothelin-1/endothelin A receptor axis activates RhoA GTPase in epithelial ovarian cancer by Tocci, Piera, Caprara, Valentina, Cianfrocca, Roberta, Sestito, Rosanna, Di Castro, Valeriana, Bagnato, Anna, Rosanò, Laura

“…The endothelin-1 (ET-1)/ET A receptor (ETAR) signaling pathway is critical driver of epithelial ovarian cancer (EOC) progression. Emerging evidences…”
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Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression by Cianfrocca, Roberta, Tocci, Piera, Rosanò, Laura, Caprara, Valentina, Sestito, Rosanna, Di Castro, Valeriana, Bagnato, Anna

“…Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote…”
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Targeting endothelin-1 receptor/β-arrestin1 network for the treatment of ovarian cancer by Rosanò, Laura, Cianfrocca, Roberta, Sestito, Rosanna, Tocci, Piera, Di Castro, Valeriana, Bagnato, Anna

“…Endothelin-1 receptor (ET-1R)/β-arrestin1 (β-arr1) signaling is dysregulated in ovarian cancer. This signaling circuit enables cancer cells to engage several…”
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