Search Results - "Tocci, Michael J"

The Consequence of Human Kindness by Tocci, Michael J., MD

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Two for One by Tocci, Michael J., MD

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The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding by Frantz, Betsy, Klatt, Tracey, Pang, Margaret, Parsons, Janey, Rolando, Anna, Williams, Hollis, Tocci, Michael J, O'Keef, Stephen J, O'Neill, Edward A

“…The serine/threonine kinase p38 is a ubiquitous, highly conserved, stress responsive, signal-transducing enzyme. It regulates the production of proinflammatory…”
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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin by O'Keefe, Stephen J, Tamura, Jun'ichi, Kincaid, Randall L, Tocci, Michael J, O'Neill, Edward A

“…Antigen recognition by the T-cell receptor (TCR) initiates events including lymphokine gene transcription, particularly interleukin-2, that lead to T-cell…”
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The 2005 Model of the Clinical Practice of Emergency Medicine: The 2007 Update by Thomas, Harold A., MD, Beeson, Michael S., MD, Binder, Louis S., MD, Brunett, Patrick H., MD, Carter, Merle A., MD, Chisholm, Carey D., MD, McGee, Douglas L., DO, Perina, Debra G., MD, Tocci, Michael J., MD

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The Central Cannabinoid CB1 Receptor Is Required for Diet-Induced Obesity and Rimonabant's Antiobesity Effects in Mice by Pang, Zhen, Wu, Nancy N., Zhao, Weiguang, Chain, David C., Schaffer, Erica, Zhang, Xin, Yamdagni, Preeti, Palejwala, Vaseem A., Fan, Chunpeng, Favara, Sarah G., Dressler, Holly M., Economides, Kyriakos D., Weinstock, Daniel, Cavallo, Jean S., Naimi, Souad, Galzin, Anne‐Marie, Guillot, Etienne, Pruniaux, Marie‐Pierre, Tocci, Michael J., Polites, H. Greg

“…Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the…”
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The 2005 Model of the Clinical Practice of Emergency Medicine: The 2007 Update by Thomas, Harold A., Beeson, Michael S., Binder, Louis S., Brunett, Patrick H., Carter, Merle A., Chisholm, Carey D., McGee, Douglas L., Perina, Debra G., Tocci, Michael J.

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A cell-based protein-protein interaction method using a permuted luciferase reporter by Eishingdrelo, Haifeng, Cai, Jidong, Weissensee, Paul, Sharma, Praveen, Tocci, Michael J, Wright, Paul S

“…We have developed a novel cell-based protein-protein interaction assay method. The method relies on conversion of an inactive permuted luciferase containing a…”
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GPR40 is partially required for insulin secretion following activation of β 3-adrenergic receptors by Pang, Zhen, Wu, Nancy, Zhang, Xin, Avallone, Roberta, Croci, Tiziano, Dressler, Holly, Palejwala, Vaseem, Ferrara, Pascual, Tocci, Michael J., Polites, H. Gregory

“…The free fatty acid (FFA) receptor GPR40, expressed by pancreatic β-cells, may be responsible for insulin release following β 3 adrenoceptor (Adrb3)…”
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Recent advances in the mechanism of action of cyclosporine and FK506 by Tocci, M J, Sigal, N H

“…The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these…”
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Expression and Immunoaffinity Purification of Human Inducible Nitric-oxide Synthase by Calaycay, Jimmy R., Kelly, Theresa M., MacNaul, Karen L., McCauley, Ermenegilda D., Qi, Hongbo, Grant, Stephan K., Griffin, Patrick R., Klatt, Tracey, Raju, S.M., Nussler, Andreas K., Shah, Shrenik, Weidner, Jeffrey R., Williams, Hollis R., Wolfe, Gloria C., Geller, David A., Billiar, Timothy R., MacCoss, Malcolm, Mumford, Richard A., Tocci, Michael J., Schmidt, John A., Wong, Kenny K., Hutchinson, Nancy I.

“…Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and…”
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GPR40 is partially required for insulin secretion following activation of beta sub(3)-adrenergic receptors by Pang, Zhen, Wu, Nancy, Zhang, Xin, Avallone, Roberta, Croci, Tiziano, Dressler, Holly, Palejwala, Vaseem, Ferrara, Pascual, Tocci, Michael J, Polites, HGregory

“…The free fatty acid (FFA) receptor GPR40, expressed by pancreatic beta -cells, may be responsible for insulin release following beta sub(3) adrenoceptor…”
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GPR40 is partially required for insulin secretion following activation of β3-adrenergic receptors by Pang, Zhen, Wu, Nancy, Zhang, Xin, Avallone, Roberta, Croci, Tiziano, Dressler, Holly, Palejwala, Vaseem, Ferrara, Pascual, Tocci, Michael J., Polites, H. Gregory

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Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice by Zheng, Hui, Fletcher, Daniel, Kozak, Wieslaw, Jiang, Minghao, Hofmann, Kathryn J., Corn, Carole A., Soszynski, Darlusz, Grabiec, Christina, Trumbauer, Myrna E., Shaw, Alan, Kostura, Matthew J., Stevens, Karla, Rosen, Hugh, North, Robert J., Chen, Howard Y., Tocci, Michael J., Kluger, Matthew J., Van der Ploeg, Lex H.T.

“…We used gene targeting in embryonic stem cells to introduce an IL-1β null allele in mice. The IL-1β-deficient mice develop normally and are apparently healthy…”
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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes by Thornberry, Nancy A, Bull, Herbert G, Calaycay, Jimmy R, Chapman, Kevin T, Howard, Andrew D, Kostura, Matthew J, Miller, Douglas K, Molineaux, Susan M, Weidner, Jeffrey R, Aunins, John, Elliston, Keith O, Ayala, Julia M, Casano, Francesca J, Chin, Jayne, Ding, Gloria J.-F, Egger, Linda A, Gaffney, Erin P, Limjuco, Guadalupe, Palyha, Oksana C, Raju, S. M, Rolando, Anna M, Salley, J. Paul, Yamin, Ting-Ting, Lee, Terry D, Shively, John E, MacCross, Malcolm, Mumford, Richard A, Schmidt, John A, Tocci, Michael J

“…Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification…”
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Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression by MacNaul, K L, Chartrain, N, Lark, M, Tocci, M J, Hutchinson, N I

“…Primary and passaged human synovial fibroblasts isolated from rheumatoid pannus were treated with recombinant interleukin-1 (IL-1) alpha or beta, tumor…”
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Identification of a Monocyte Specific Pre-Interleukin 1β Convertase Activity by Kostura, Matthew J., Tocci, Michael J., Limjuco, Guadalupe, Chin, Jayne, Cameron, Patricia, Hillman, Andrew G., Chartrain, Nicole A., Schmidt, John A.

“…Interleukin 1 (IL-1) is a lymphokine secreted by monocytes in response to a variety of inflammatory stimuli. IL-1β , the predominant form of IL-1 produced by…”
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GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors by Pang, Zhen, Wu, Nancy, Zhang, Xin, Avallone, Roberta, Croci, Tiziano, Dressler, Holly, Palejwala, Vaseem, Ferrara, Pascual, Tocci, Michael J, Polites, H Gregory

“…The free fatty acid (FFA) receptor GPR40, expressed by pancreatic beta-cells, may be responsible for insulin release following beta(3) adrenoceptor (Adrb3)…”
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IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31- kDa IL-1 alpha by Howard, AD, Kostura, MJ, Thornberry, N, Ding, GJ, Limjuco, G, Weidner, J, Salley, JP, Hogquist, KA, Chaplin, DD, Mumford, RA

“…IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2)…”
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Structure and function of interleukin-1 beta converting enzyme by Tocci, M J

“…An overwhelming body of evidence has shown that IL-1 beta is a major mediator of inflammatory disease (Tocci and Schmidt, 1996). The discovery of ICE, a unique…”
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