Search Results - "Toboz, Phoenix"
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The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)
Published in The Journal of biological chemistry (01-09-2022)“…La-related protein 1 (LARP1) has been identified as a key translational inhibitor of terminal oligopyrimidine (TOP) mRNAs downstream of the nutrient sensing…”
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Journal Article -
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The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages
Published in Proceedings of the National Academy of Sciences - PNAS (30-08-2022)“…GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that controls messenger RNA translation in response to amino acid availability…”
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Journal Article -
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TDP-43 C-Terminal Fragment Spreading and Toxicity in C. elegans
Published 01-01-2019“…Many neurodegenerative disorders are characterized by abnormal accumulation of misfolded proteins in nerve cells leading to selective neurotoxicity. Moreover,…”
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Dissertation