Search Results - "Tobinaga, Hiroyuki"

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening by Tobinaga, Hiroyuki, Kameyama, Takayuki, Oohara, Miho, Kobayashi, Naotake, Ohdan, Masahide, Ishizuka, Natsuki, Kume, Masaharu, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Kinoshita, Haruki, Shimada, Shinji, Shinohara, Shunji, Kai, Hiroyuki

“…[Display omitted] The P2X3 receptor is primarily expressed in the peripheral sensory nerves, and therefore, antagonists of this receptor may be useful for the…”
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives by Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Taoda, Yoshiyuki, Hata, Kayoko, Hasegawa, Tsuyoshi, Tada, Yukio, Kurihara, Naoko, Kanda, Yasuhiko, Yagi, Shigenori, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki

“…[Display omitted] •Pyrropyrazolone derivatives as a P2X3 receptor antagonist were synthesized.•The SAR studies were started from hit compound 3 with reference…”
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds by Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Tada, Yukio, Fuchino, Kouki, Jikihara, Sae, Endoh, Takeshi, Kurihara, Naoko, Kanda, Yasuhiko, Ogawa, Masayoshi, Tamura, Naomi, Yagi, Shigenori, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki

“…[Display omitted] Some P2X3 receptor antagonists have been developed as new therapeutic drugs for pain. We discovered a novel chemotype of P2X3 receptor…”
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Magnetic property of 1:2 mixture of Co( p-tolsal) 2; p-tolsal = N- p-tolylsalicylideniminato, and cyclic pentacarbene–pyridine with S = 10/2 in dilute frozen solution by Tobinaga, Hiroyuki, Suehiro, Madoka, Ito, Tetsuji, Zhou, Guangyuan, Karasawa, Satoru, Koga, Noboru

“…A cyclic pentadiazo-pyridine derivative, cD5py, was prepared. The 1:2 complex of Co( p-tolsal) 2 with cD5py in frozen solution after irradiation functions as…”
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