Search Results - "Tobin, M D"

What can genetics tell us about the cause of fixed airflow obstruction? by Wain, L. V., Artigas, M. Soler, Tobin, M. D.

“…Summary Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide with smoking being the most important risk…”
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Body mass index, asthma, and genetic variation by Tobin, M. D.

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Genome-wide association study to identify genetic determinants of severe asthma by Wan, Y I, Shrine, N R G, Soler Artigas, M, Wain, L V, Blakey, J D, Moffatt, M F, Bush, A, Chung, K F, Cookson, W O C M, Strachan, D P, Heaney, L, Al-Momani, B A H, Mansur, A H, Manney, S, Thomson, N C, Chaudhuri, R, Brightling, C E, Bafadhel, M, Singapuri, A, Niven, R, Simpson, A, Holloway, J W, Howarth, P H, Hui, J, Musk, A W, James, A L, Brown, M A, Baltic, S, Ferreira, M A R, Thompson, P J, Tobin, M D, Sayers, I, Hall, I P

“…The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and…”
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Infectious disease models in zebrafish by Sullivan, C, Matty, M A, Jurczyszak, D, Gabor, K A, Millard, P J, Tobin, D M, Kim, C H

“…In recent years, the zebrafish (Danio rerio) has developed as an important alternative to mammalian models for the study of hostpathogen interactions. Because…”
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DataSHIELD: resolving a conflict in contemporary bioscience—performing a pooled analysis of individual-level data without sharing the data by Wolfson, Michael, Wallace, Susan E, Masca, Nicholas, Rowe, Geoff, Sheehan, Nuala A, Ferretti, Vincent, LaFlamme, Philippe, Tobin, Martin D, Macleod, John, Little, Julian, Fortier, Isabel, Knoppers, Bartha M, Burton, Paul R

“…Background Contemporary bioscience sometimes demands vast sample sizes and there is often then no choice but to synthesize data across several studies and to…”
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Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family by Zallen, J A, Peckol, E L, Tobin, D M, Bargmann, C I

“…The Caenorhabditis elegans sax-1 gene regulates several aspects of neuronal cell shape. sax-1 mutants have expanded cell bodies and ectopic neurites in many…”
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Adiposity as a cause of cardiovascular disease: a Mendelian randomization study by Hägg, Sara, Fall, Tove, Ploner, Alexander, Mägi, Reedik, Fischer, Krista, Draisma, Harmen H M, Kals, Mart, de Vries, Paul S, Dehghan, Abbas, Willems, Sara M, Sarin, Antti-Pekka, Kristiansson, Kati, Nuotio, Marja-Liisa, Havulinna, Aki S, de Bruijn, Renée F A G, Ikram, M Arfan, Kuningas, Maris, Stricker, Bruno H, Franco, Oscar H, Benyamin, Beben, Gieger, Christian, Hall, Alistair S, Huikari, Ville, Jula, Antti, Järvelin, Marjo-Riitta, Kaakinen, Marika, Kaprio, Jaakko, Kobl, Michael, Mangino, Massimo, Nelson, Christopher P, Palotie, Aarno, Samani, Nilesh J, Spector, Tim D, Strachan, David P, Tobin, Martin D, Whitfield, John B, Uitterlinden, André G, Salomaa, Veikko, Syvänen, Ann-Christine, Kuulasmaa, Kari, Magnusson, Patrik K, Esko, Tõnu, Hofman, Albert, de Geus, Eco J C, Lind, Lars, Giedraitis, Vilmantas, Perola, Markus, Evans, Alun, Ferrières, Jean, Virtamo, Jarmo, Kee, Frank, Tregouet, David-Alexandre, Arveiler, Dominique, Amouyel, Philippe, Gianfagna, Francesco, Brambilla, Paolo, Ripatti, Samuli, van Duijn, Cornelia M, Metspalu, Andres, Prokopenko, Inga, McCarthy, Mark I, Pedersen, Nancy L, Ingelsson, Erik

“…Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate…”
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Beyond “misunderstanding”: Written information and decisions about taking part in a genetic epidemiology study by Dixon-Woods, Mary, Ashcroft, Richard E., Jackson, Clare J., Tobin, Martin D., Kivits, Joelle, Burton, Paul R., Samani, Nilesh J.

“…Although the need to obtain “informed” consent is institutionalised as a principle of ethical practice in research, there is persistent evidence that the…”
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Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons by Tobin, David M., Madsen, David M., Kahn-Kirby, Amanda, Peckol, Erin L., Moulder, Gary, Barstead, Robert, Maricq, Andres V., Bargmann, Cornelia I.

“…C. elegans OSM-9 is a TRPV channel protein involved in sensory transduction and adaptation. Here, we show that distinct sensory functions arise from different…”
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Effect of fatigue on hamstring coactivation during isokinetic knee extensions by Weir, J P, Keefe, D A, Eaton, J F, Augustine, R T, Tobin, D M

“…We examined the effect of fatigue of the quadriceps muscles on coactivation of the hamstring muscles and determined if the response is different between two…”
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Joint Effect of Single-Nucleotide Polymorphisms and Smoking Exposure in Chronic Obstructive Pulmonary Disease Risk/Reply by Young, Robert P, Hopkins, Raewyn J, Hay, Bryan A, Gamble, Greg D, Artigas, M Soler, Wain, L V, Tobin, M D, Hall, I P

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Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli by de Bono, Mario, Tobin, David M, Davis, M. Wayne, Avery, Leon, Bargmann, Cornelia I

“…Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive…”
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South Asian ethnicity and risk of childhood accidents: an ecological study at enumeration district level in Leicester by Tobin, M. D., Milligan, J., Shukla, R., Crump, B., Burton, P. R.

“…Background Surveys of ‘self‐reported’ accidents suggest that South Asian children in the United Kingdom may have lower rates of childhood accidents, but little…”
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Commentary: Development of Mendelian randomization: from hypothesis test to ‘Mendelian deconfounding’ by Tobin, Martin D, Minelli, Cosetta, Burton, Paul R, Thompson, John R

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Olfactory recognition and discrimination in Caenorhabditis elegans by Chou, J H, Troemel, E R, Sengupta, P, Colbert, H A, Tong, L, Tobin, D M, Roayaie, K, Crump, J G, Dwyer, N D, Bargmann, C I

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Rheumatoid arthritis association at 6q23 by Worthington, Jane, Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David

“…The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a…”
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Enhancements to a multiple model adaptive estimator/image-tracker by Tobin, D.M., Maybeck, P.S.

“…Three major enhancements to a previously devised multiple model adaptive estimator (MMAE) for target image tracking are developed and analyzed. These are:…”
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C14 INTERSTITIAL LUNG DISEASE: ADVANCES ACROSS THE FIELD: Genome-Wide Association Study Of Survival In Patients With Idiopathic Pulmonary Fibrosis by Oldham, J M, Allen, R, Lorenzo-Salazar, J, Ma, S, Huang, Y, Zhang, Y, Kaminski, N, Seldin, M, Tobin, M D, Flores, C, Wain, L V, Jenkins, R G, Noth, I

“…Recent genome-wide association studies (GWAS) identified single nucleotide polymorphisms (SNPs) associated with IPF susceptibility, but few SNPs identified by…”
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Joint Effect of Single-Nucleotide Polymorphisms and Smoking Exposure in Chronic Obstructive Pulmonary Disease Risk by Soler Artigas, M., Wain, L. V., Tobin, M. D., Hall, I. P.

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B31 INFLAMMATION AND COPD: The Uk Bileve Study: The First Genetic Study In Uk Biobank Identifies Novel Regions Associated With Airway Obstruction And Smoking Behaviour by Miller, S, Wain, L, Shrine, N, Ntalla, I, Cook, J, Sayers, I, Morris, A, Zeggini, E, Marchini, J, Deloukas, P, Hansell, A, Hubbard, R, Pavord, I, Thomson, N C, Strachan, D, Tobin, M D, Hall, I

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