Search Results - "Tobin, J. F."

Administration of myostatin does not alter fat mass in adult mice by Stolz, L.E, Li, D, Qadri, A, Jalenak, M, Klaman, L.D, Tobin, J.F

“…Myostatin, a member of the TGF-beta superfamily, is produced by skeletal muscle and acts as a negative regulator of muscle mass. It has also been suggested…”
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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses by Somers, William S, Stamper, Carin C, Zhang, Yan, Tobin, James F, Erbe, David V, Ikemizu, Shinji, Davis, Simon J, Stahl, Mark L, Seehra, Jasbir, Mosyak, Lidia

“…Optimal immune responses require both an antigen-specific and a co-stimulatory signal. The shared ligands B7-1 and B7-2 on antigen-presenting cells deliver the…”
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Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling by Erbe, D. V., Klaman, L. D., Wilson, D. P., Wan, Z.-K., Kirincich, S. J., Will, S., Xu, X., Kung, L., Wang, S., Tam, S., Lee, J., Tobin, J. F.

“…A growing percentage of the population is resistant to two key hormones – insulin and leptin – as a result of increased obesity, often leading to significant…”
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Purification and properties of RhaR, the positive regulator of the L-rhamnose operons of Escherichia coli by Tobin, J F, Schleif, R F

“…The product of the rhaR gene, which regulates the level of mRNA produced from the four L-rhamnose-inducible promoters of the rhamnose operon, has been…”
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Positive regulation of the Escherichia coli L-rhamnose operon is mediated by the products of tandemly repeated regulatory genes by Tobin, J F, Schleif, R F

“…The rhaC gene, whose product is the positive activator of the genes required for L-rhamnose utilization, has been cloned along with the rhamnose structural…”
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Homologous recombination in Leishmania enriettii by TOBIN, J. F, LABAN, A, WIRHT, D. F

“…We have used derivatives of the recently developed stable transfection vector pALT-Neo to formally demonstrate that Leishmania enriettii contains the enzymatic…”
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Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice by Perreault, M, Will, S, Panza, D, Gareski, T, Harding, K, Kubasiak, D, Jalenak, M, Gartrell, K, Wang, S, Bollag, G, Artis, D.R, Ibrahim, P.N, Womack, P, Lin, J.J, Saiah, E, Mansour, T.S, Vlasuk, G.P, Erbe, D.V, Tobin, J.F

“…Aim: Peroxisome proliferator activated receptors (PPARs) are nuclear receptors involved in glucose and lipid metabolism. Three isoforms of PPARs have been…”
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Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin‐12 by Yoon, Christina, Johnston, Steven C., Tang, Jin, Stahl, Mark, Tobin, James F., Somers, William S.

“…Human interleukin‐12 (IL‐12, p70) is an early pro‐inflammatory cytokine, comprising two disulfide‐linked subunits, p35 and p40. We solved the crystal…”
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Transcription from the rha operon psr promoter by Tobin, J F, Schleif, R F

“…S1 nuclease mapping experiments performed with RNA extracted from cell lines that were unable to metabolize L-rhamnose demonstrated that L-rhamnose and not a…”
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Transfected Leishmania expressing biologically active IFN-gamma by Tobin, JF, Reiner, SL, Hatam, F, Zheng, S, Leptak, CL, Wirth, DF, Locksley, RM

“…Infection of susceptible BALB/c mice with Leishmania major leads to progressive infection with the failure to expand and activate Th1 CD4+ T cells that…”
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Cross-induction of the L-fucose system by L-rhamnose in Escherichia coli by CHEN, Y.-M, TOBIN, J. F, ZHU, Y, SCHLEIF, R. F, LIN, E. C. C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutational analysis of a signal sequence required for protein secretion in Leishmania major by Tobin, J F, Wirth, D F

“…In eukaryotes, amino-terminal extensions, signal sequences, mediate the translocation of lysosomal, membrane and secreted proteins into the lumen of the…”
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Small Molecule Ligands Define a Binding Site on the Immune Regulatory Protein B7.1 by Erbe, David V., Wang, Suyue, Xing, Yuzhe, Tobin, James F.

“…The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T…”
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A sequence insertion targeting vector for Leishmania enriettii by Tobin, J.F. (Harvard School of Public Health, Boston, MA), Wirth, D.F

“…We have demonstrated previously that Leishmania enriettii contains the enzymatic machinery to mediate efficient interplasmidic homologous recombination. In…”
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Stable expression of the bacterial neor gene in Leishmania enriettii by LABAN, A, FINBARR TOBIN, J, CUROTTO DE LAFAILLE, M. A, WIRTH, D. F

“…Molecular genetic studies in parasitic protozoa have been hindered by the lack of methods for the introduction and expression of modified or foreign genes in…”
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Exploratory studies of abnormal behavior in the rat by Bernhardt, K. S, Tobin, F. J, Signori, E

“…With white rats as subjects the authors explored a number of situations such as increasing the difficulty of discrimination to the point of confusion, a…”
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Determination of explosive hazard of gases generated during pyrolysis of motor stator encapsulants by Diliberti, J., Tobin, J. F.

“…Some motors used in severe shipboard environments (moisture) are protected by encapsulating the stators. When failure occurs, the usual method of removing the…”
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Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases by Tobin, James F, Celeste, Anthony J

“…Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is…”
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Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease by Tobin, James F., Celeste, Anthony J.

“…Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) control the development and homeostasis of multiple tissue types in many…”
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Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I by Xiang, Jason, Ipek, Manus, Suri, Vipin, Massefski, Walt, Pan, Ning, Ge, Ying, Tam, May, Xing, Yuzhe, Tobin, James F., Xu, Xin, Tam, Steve

“…[Display omitted] The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1 inhibitors and the serendipitous discovery of β-keto…”
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