Search Results - "Tobin, DJ"

Biochemistry of human skin--our brain on the outside by Tobin, Desmond J

“…The skin, our body's largest organ, is located at the interface between the external and internal environments, and so is strategically placed to provide not…”
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Dilated Cardiomyopathy in Mice Deficient for the Lysosomal Cysteine Peptidase Cathepsin L by Stypmann, Jörg, Gläser, Kerstin, Roth, Wera, Tobin, Desmond J., Petermann, Ivonne, Matthias, Rainer, Mönnig, Gerold, Haverkamp, Wilhelm, Breithardt, Günter, Schmahl, Wolfgang, Peters, Christoph, Reinheckel, Thomas

“…Dilated cardiomyopathy is a frequent cause of heart failure and is associated with high mortality. Progressive remodeling of the myocardium leads to increased…”
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Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls by Bollard, SM, Howard, J, Casalou, C, Kelly, BS, O'Donnell, K, Fenn, G, O'Reilly, J, Milling, R, Shields, M, Wilson, M, Ajaykumar, A, Triana, K, Wynne, K, Tobin, DJ, Kelly, PA, McCann, A, Potter, SM

“…•Plasma-derived Extracellular Vesicles (EVs) from patients with melanoma have similar size and concentration compared to those from healthy controls.•Proteins…”
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Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation by Slominski, Andrzej, Tobin, Desmond J, Shibahara, Shigeki, Wortsman, Jacobo

“…Department of Pathology, University of Tennessee, Memphis, Tennessee; Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire,…”
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cutaneous serotoninergic/melatoninergic system: securing a place under the sun by Slominski, Andrzej, Wortsman, Jacobo, Tobin, Desmond J

“…It was recently discovered that mammalian skin can produce serotonin and transform it into melatonin. Pathways for the biosynthesis and biodegradation of…”
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Isolation and Long-Term Culture of Human Hair-Follicle Melanocytes by Tobin, Desmond J., Colen, Stephen R., Bystryn, Jean-Claude

“…We report a method to establish long-term cultures of melanocytes derived from human hair follicles. Normal human scalp was transected 1 mm below the…”
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Hair Follicle Pigmentation by Slominski, Andrzej, Wortsman, Jacobo, Plonka, Przemyslaw M., Schallreuter, Karin U., Paus, Ralf, Tobin, Desmond J.

“…Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between…”
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NF-κB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth by Schmidt-Ullrich, Ruth, Tobin, Desmond J., Lenhard, Diana, Schneider, Pascal, Paus, Ralf, Scheidereit, Claus

“…A novel function of NF-κB in the development of most ectodermal appendages, including two types of murine pelage hair follicles, was detected in a mouse model…”
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Opioids and the skin - where do we stand? by Bigliardi, Paul L., Tobin, Desmond J., Gaveriaux-Ruff, Claire, Bigliardi-Qi, Mei

“…:  The common ectodermal origin of the skin and nervous systems can be expected to predict likely interactions in the adult. Over the last couple of decades…”
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Graying: gerontobiology of the hair follicle pigmentary unit by Tobin, D.J, Paus, R

“…The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetical pathway underling this phenomenon is called…”
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Functional activity of serotoninergic and melatoninergic systems expressed in the skin by Slominski, Andrzej, Pisarchik, Alexander, Zbytek, Blazej, Tobin, Desmond J., Kauser, Söbia, Wortsman, Jacobo

“…We tested the expression of genes coding receptors of a cutaneous serotoninergic/melatoninergic system in whole human skin and in normal and pathologic…”
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Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging by Van Neste, Dominique, Tobin, Desmond J

“…The tight coupling of hair follicle melanogenesis to the hair growth cycle dramatically distinguishes follicular melanogenesis from the continuous…”
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Serotoninergic and melatoninergic systems are fully expressed in human skin by Slominski, Andrzej, Pisarchik, Alexander, Semak, Igor, Sweatman, Trevor, Wortsman, Jacobo, Szczesniewski, Andre, Slugocki, George, McNulty, John, Kauser, Söbia, Tobin, Desmond J., Jing, Chen, Johansson, Olle

“…ABSTRACT We investigated the cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to…”
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The Mitochondrial Electron Transport Chain Is Dispensable for Proliferation and Differentiation of Epidermal Progenitor Cells by Baris, Olivier R, Klose, Anke, Kloepper, Jennifer E, Weiland, Daniela, Neuhaus, Johannes F.G, Schauen, Matthias, Wille, Anna, Müller, Alexander, Merkwirth, Carsten, Langer, Thomas, Larsson, Nils‐Göran, Krieg, Thomas, Tobin, Desmond J, Paus, Ralf, Wiesner, Rudolf J

“…Tissue stem cells and germ line or embryonic stem cells were shown to have reduced oxidative metabolism, which was proposed to be an adaptive mechanism to…”
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On the role of melatonin in skin physiology and pathology by Slominski, Andrzej, Fischer, Tobias W, Zmijewski, Michal A, Wortsman, Jacobo, Semak, Igor, Zbytek, Blazej, Slominski, Radomir M, Tobin, Desmond J

“…Melatonin has been experimentally implicated in skin functions such as hair growth cycling, fur pigmentation, and melanoma control, and melatonin receptors are…”
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Differential Expression of a Cutaneous Corticotropin-Releasing Hormone System by Slominski, Andrzej, Pisarchik, Alexander, Tobin, Desmond J, Mazurkiewicz, Joseph E, Wortsman, Jacobo

“…We completed the mapping of a cutaneous CRH signaling system in two species with widely different determinants of skin functions, humans and mice. In human…”
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Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control by Tobin, Desmond J., Magerl, Markus, Gunin, Andrei, Handijski, Bori, Paus, Ralf

“…The continuously remodeled hair follicle is a uniquely exploitable epithelial-mesenchymal interaction system. In contrast to the cyclical fate of the hair…”
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Characterization of hair follicle antigens targeted by the anti-hair follicle immune response by Tobin, Desmond J

“…Alopecia areata is a common disfiguring hair loss disorder that primarily affects the hair follicle as it enters the prolonged growth phase called anagen. The…”
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Regulation of Human Epidermal Melanocyte Biology By β-Endorphin by Kauser, Söbia, Schallreuter, Karin U., Thody, Anthony J., Tobin, Desmond J., Gummer, Christopher

“…β-Endorphin is an opioid peptide cleaved from the precursor pro-hormone pro-opiomelanocortin, from which other peptides such as adrenocorticotropic hormone,…”
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The human hair follicle immune system: cellular composition and immune privilege by Christoph, T., Müller-Röver, S., Audring, H., Tobin, D.J., Hermes, B., Cotsarelis, G., Rückert, R., Paus, R.

“…The immunology of the hair follicle, its relationship with the ‘skin immune system’ and its role in hair diseases remain biologically intriguing and clinically…”
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