New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on mono...

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Bibliographic Details
Published in:	Journal of tissue engineering Vol. 8; p. 2041731417744485
Main Authors:	Hoffmann, Andreas, Leonards, Holger, Tobies, Nora, Pongratz, Ludwig, Kreuels, Klaus, Kreimendahl, Franziska, Apel, Christian, Wehner, Martin, Nottrodt, Nadine
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-01-2017 SAGE Publishing
Subjects:	Design and Manufacture of Tissue Engineered Products using Additive Manufacturing Techniques Bioprinting functional surface photochemistry thiol-ene stereolithography
Online Access:	Get full text
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Summary:	Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-7314 2041-7314
DOI:	10.1177/2041731417744485