Search Results - "Tobias, Peter S."

Emerging role of Toll-like receptors in atherosclerosis by Curtiss, Linda K., Tobias, Peter S.

“…Atherosclerosis is inflammation of the vessel wall of the arterial tree. This inflammation arises at specific areas that experience disturbed blood flow such…”
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Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin by Owens, 3rd, A Phillip, Passam, Freda H, Antoniak, Silvio, Marshall, Stephanie M, McDaniel, Allison L, Rudel, Lawrence, Williams, Julie C, Hubbard, Brian K, Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S, Curtiss, Linda K, Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P, Moriarty, Patrick M, Nagarajan, Shanmugam, Furie, Barbara C, Furie, Bruce, Johns, Douglas G, Temel, Ryan E, Mackman, Nigel

“…Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality…”
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Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events by Mullick, Adam E, Soldau, Katrin, Kiosses, William B, Bell, 3rd, Thomas A, Tobias, Peter S, Curtiss, Linda K

“…Toll-like receptors (TLRs) are pattern recognition receptors of innate immunity. TLRs initiate inflammatory pathways that may exacerbate chronic inflammatory…”
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TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways by Shigeoka, Alana A, Holscher, Todd D, King, Andrew J, Hall, Frank W, Kiosses, William B, Tobias, Peter S, Mackman, Nigel, McKay, Dianne B

“…TLRs are an evolutionarily conserved family of cell membrane proteins believed to play a significant role in innate immunity and the response to tissue injury,…”
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Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists by Curtiss, Linda K., Black, Audrey S., Bonnet, David J., Tobias, Peter S.

“…Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in…”
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MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4 by Owens, A Phillip, Rateri, Debra L, Howatt, Deborah A, Moore, Kathryn J, Tobias, Peter S, Curtiss, Linda K, Lu, Hong, Cassis, Lisa A, Daugherty, Alan

“…OBJECTIVE—The purpose of this study was to determine whether myeloid differentiation factor 88 (MyD88) and its related Toll-like receptors (TLRs) 2 and 4…”
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Recognition of Gram-negative bacteria and endotoxin by the innate immune system by Ulevitch, Richard J, Tobias, Peter S

“…Until about 10 years ago the exact mechanisms controlling cellular responses to the endotoxin – or lipopolysaccharide (LPS) – of Gram-negative bacteria were…”
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Flow-Dependent Regulation of Endothelial Toll-Like Receptor 2 Expression Through Inhibition of SP1 Activity by Dunzendorfer, Stefan, Lee, Hyun-Ku, Tobias, Peter S

“…Innate immune system activation is associated with atherosclerotic lesion development. The specific sites of lesion development are believed to be defined by…”
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Toll‐like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS‐responses by Dunzendorfer, Stefan, Lee, Hyun‐Ku, Soldau, Katrin, Tobias, Peter S.

“…ABSTRACT Endothelial cells are activated by microbial agonists through Toll‐like receptors (TLRs) to express inflammatory mediators; this is of significance in…”
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The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice by Richards, M Rachel, Black, Audrey S, Bonnet, David J, Barish, Grant D, Woo, Connie W, Tabas, Ira, Curtiss, Linda K, Tobias, Peter S

“…Signaling through MyD88, an adaptor utilized by all TLRs except TLR3, is pro-atherogenic; however, it is unknown whether signaling through…”
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Interaction of SP-A (surfactant protein A) with bacterial rough lipopolysaccharide (Re-LPS), and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding protein by García-Verdugo, Ignacio, Sánchez-Barbero, Fernando, Soldau, Katrin, Tobias, Peter S, Casals, Cristina

“…SP-A (surfactant protein A) is a lipid-binding collectin primarily involved in innate lung immunity. SP-A interacts with the bacterial rough LPS…”
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Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death by Kim, Sung Ouk, Ono, Koh, Tobias, Peter S, Han, Jiahuai

“…Activation-induced cell death in macrophages has been observed, but the mechanism remains largely unknown. Activation-induced cell death in macrophages can be…”
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Modulation of atherosclerosis in mice by Toll-like receptor 2 by Mullick, Adam E, Tobias, Peter S, Curtiss, Linda K

“…Epidemiologic evidence has established a relationship between microbial infection and atherosclerosis. Mammalian TLRs provide clues on the mechanism of this…”
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Lipopolysaccharide (LPS)-binding Protein Inhibits Responses to Cell-bound LPS by Thompson, Patricia A., Tobias, Peter S., Viriyakosol, Suganya, Kirkland, Theo N., Kitchens, Richard L.

“…Lipopolysaccharide (LPS)-binding protein (LBP) is an acute phase reactant that may play a dual role in vivo, both potentiating and decreasing cell responses to…”
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Mutational Analysis of Membrane and Soluble Forms of Human MD-2 by Viriyakosol, Suganya, Tobias, Peter S., Kirkland, Theo N.

“…Toll-like receptor 4 and MD-2 form a receptor for lipopolysaccharide (LPS), a major constituent of Gram-negative bacteria. MD-2 is a 20-25-kDa extracellular…”
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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein by Wright, Samuel D., Ramos, Robert A., Tobias, Peter S., Ulevitch, Richard J., Mathison, John C.

“…Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-α (TNF-α)…”
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Double-Stranded RNA-Mediated TLR3 Activation Is Enhanced by CD14 by Lee, Hyun-Ku, Dunzendorfer, Stefan, Soldau, Katrin, Tobias, Peter S.

“…CD14 is a well-known pattern-recognition receptor in the innate immune system. Here, we show that CD14 enhances double-stranded RNA (dsRNA)-mediated Toll-like…”
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Structure and Function of Lipopolysaccharide Binding Protein by Schumann, Ralf R., Leong, Steven R., Flaggs, Gail W., Gray, Patrick W., Wright, Samuel D., Mathison, John C., Tobias, Peter S., Ulevitch, Richard J.

“…The primary structure of lipopolysaccharide binding protein (LBP), a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides…”
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TLR4 Is the Signaling but Not the Lipopolysaccharide Uptake Receptor by Dunzendorfer, Stefan, Lee, Hyun-Ku, Soldau, Katrin, Tobias, Peter S

“…TLR4 is the primary recognition molecule for inflammatory responses initiated by bacterial LPS (endotoxin). Internalization of endotoxin by various cell types…”
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Phagocytosis of gram-negative bacteria by a unique CD14-dependent mechanism by Schiff, Deborah E., Kline, Lois, Soldau, Katrin, Lee, J. D., Pugin, Jerome, Tobias, Peter S., Ulevitch, Richard J.

“…THP‐l‐derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI) ‐anchored or transmembrane forms of human CD14. CD14…”
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