Search Results - "Tobias, Jon"

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    DNA methylation patterns in cord blood DNA and body size in childhood by Relton, Caroline L, Groom, Alexandra, St Pourcain, Beate, Sayers, Adrian E, Swan, Daniel C, Embleton, Nicholas D, Pearce, Mark S, Ring, Susan M, Northstone, Kate, Tobias, Jon H, Trakalo, Joseph, Ness, Andy R, Shaheen, Seif O, Davey Smith, George

    Published in PloS one (14-03-2012)
    “…Epigenetic markings acquired in early life may have phenotypic consequences later in development through their role in transcriptional regulation with…”
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    Association between physical activity and scoliosis: a prospective cohort study by Tobias, Jon H, Fairbank, Jeremy, Harding, Ian, Taylor, Hilary J, Clark, Emma M

    Published in International journal of epidemiology (01-08-2019)
    “…Abstract Background Little is understood about the causes of adolescent onset idiopathic scoliosis (AIS). No prospective studies assessing the association…”
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    45-day mortality after 467779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study by Hunt, Linda P, Ben-Shlomo, Yoav, Clark, Emma M, Dieppe, Paul, Judge, Andrew, MacGregor, Alex J, Tobias, Jon H, Vernon, Kelly, Blom, Ashley W

    Published in The Lancet (British edition) (18-10-2014)
    “…Background Understanding the risk factors for early death after knee replacement could help to reduce the risk of mortality after this procedure. We assessed…”
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    Using multiple genetic variants as instrumental variables for modifiable risk factors by Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC

    Published in Statistical methods in medical research (01-06-2012)
    “…Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease…”
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    Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors by Frysz, Monika, Gergei, Ingrid, Scharnagl, Hubert, Smith, George Davey, Zheng, Jie, Lawlor, Deborah A, Herrmann, Markus, Maerz, Winfried, Tobias, Jon H

    Published in Journal of bone and mineral research (01-02-2022)
    “…ABSTRACT Romosozumab is a newly available treatment for osteoporosis acting by sclerostin inhibition. Its cardiovascular safety has been questioned after…”
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    Unpicking observational relationships between hip shape and osteoarthritis: hype or hope? by Faber, Benjamin G., Frysz, Monika, Tobias, Jon H.

    Published in Current opinion in rheumatology (01-01-2020)
    “…PURPOSE OF REVIEWTo review recent findings concerning the observational relationship between hip shape and hip osteoarthritis (HOA) and their shared genetic…”
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    The Impact of Small Spinal Curves in Adolescents Who Have Not Presented to Secondary Care: A Population-Based Cohort Study by Clark, Emma M, Tobias, Jon H, Fairbank, Jeremy

    Published in Spine (Philadelphia, Pa. 1976) (01-05-2016)
    “…A prospective, population-based, birth cohort study. The aim of this study was to identify whether there is any hidden burden of disease associated with…”
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    Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis by Hartley, April, Sanderson, Eleanor, Paternoster, Lavinia, Teumer, Alexander, Kaplan, Robert C, Tobias, Jon H, Gregson, Celia L

    Published in Rheumatology (Oxford, England) (06-04-2021)
    “…Abstract Objectives How insulin-like growth factor-1 (IGF-1) is related to OA is not well understood. We determined relationships between IGF-1 and…”
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    Machine Learning–Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank by Frysz, Monika, Faber, Benjamin G, Ebsim, Raja, Saunders, Fiona R, Lindner, Claudia, Gregory, Jennifer S, Aspden, Richard M, Harvey, Nicholas C, Cootes, Tim, Tobias, Jon H

    Published in Journal of bone and mineral research (01-09-2022)
    “…ABSTRACT The contribution of shape changes to hip osteoarthritis (HOA) remains unclear, as is the extent to which these vary according to HOA severity. In the…”
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    Association Between Components of Body Composition and Scoliosis: A Prospective Cohort Study Reporting Differences Identifiable Before the Onset of Scoliosis by Clark, Emma M, Taylor, Hilary J, Harding, Ian, Hutchinson, John, Nelson, Ian, Deanfield, John E, Ness, Andy R, Tobias, Jon H

    Published in Journal of bone and mineral research (01-08-2014)
    “…ABSTRACT There is an increasing body of research suggesting that low body weight is associated with scoliosis, but this is based on case‐control studies, which…”
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    Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age by Elhakeem, Ahmed, Frysz, Monika, Tilling, Kate, Tobias, Jon H, Lawlor, Deborah A

    Published in JAMA network open (02-08-2019)
    “…Bone health in early life is thought to influence the risk of osteoporosis in later life. To examine whether puberty timing is associated with bone mineral…”
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    Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: Results from a population-based study of adolescents by Deere, Kevin, Sayers, Adrian, Rittweger, Jörn, Tobias, Jon H

    Published in Journal of bone and mineral research (01-09-2012)
    “…Whether a certain level of impact needs to be exceeded for physical activity (PA) to benefit bone accrual is currently unclear. To examine this question, we…”
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    Motor Competence in Early Childhood Is Positively Associated With Bone Strength in Late Adolescence by Ireland, Alex, Sayers, Adrian, Deere, Kevin C, Emond, Alan, Tobias, Jon H

    Published in Journal of bone and mineral research (01-05-2016)
    “…ABSTRACT The onset of walking in early childhood results in exposure of the lower limb to substantial forces from weight bearing activity that ultimately…”
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    Association Between Bone Mass and Fractures in Children: A Prospective Cohort Study by Clark, Emma M, Ness, Andy R, Bishop, Nicholas J, Tobias, Jon H

    Published in Journal of bone and mineral research (01-09-2006)
    “…This is the first prospective cohort study of the association between bone mass and fracture risk in childhood. A total of 6213 children 9.9 years of age were…”
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