Search Results - "Tobias, Jon"
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90-day mortality after 409 096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis
Published in The Lancet (British edition) (28-09-2013)“…Summary Background Death within 90 days after total hip replacement is rare but might be avoidable dependent on patient and treatment factors. We assessed…”
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2
45-day mortality after 467 779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study
Published in The Lancet (British edition) (18-10-2014)“…Summary Background Understanding the risk factors for early death after knee replacement could help to reduce the risk of mortality after this procedure. We…”
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3
DNA methylation patterns in cord blood DNA and body size in childhood
Published in PloS one (14-03-2012)“…Epigenetic markings acquired in early life may have phenotypic consequences later in development through their role in transcriptional regulation with…”
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4
Association between physical activity and scoliosis: a prospective cohort study
Published in International journal of epidemiology (01-08-2019)“…Abstract Background Little is understood about the causes of adolescent onset idiopathic scoliosis (AIS). No prospective studies assessing the association…”
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5
45-day mortality after 467779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study
Published in The Lancet (British edition) (18-10-2014)“…Background Understanding the risk factors for early death after knee replacement could help to reduce the risk of mortality after this procedure. We assessed…”
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6
Using multiple genetic variants as instrumental variables for modifiable risk factors
Published in Statistical methods in medical research (01-06-2012)“…Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease…”
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7
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Published in PLoS genetics (01-02-2013)“…Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density…”
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8
Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors
Published in Journal of bone and mineral research (01-02-2022)“…ABSTRACT Romosozumab is a newly available treatment for osteoporosis acting by sclerostin inhibition. Its cardiovascular safety has been questioned after…”
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9
Unpicking observational relationships between hip shape and osteoarthritis: hype or hope?
Published in Current opinion in rheumatology (01-01-2020)“…PURPOSE OF REVIEWTo review recent findings concerning the observational relationship between hip shape and hip osteoarthritis (HOA) and their shared genetic…”
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10
The Impact of Small Spinal Curves in Adolescents Who Have Not Presented to Secondary Care: A Population-Based Cohort Study
Published in Spine (Philadelphia, Pa. 1976) (01-05-2016)“…A prospective, population-based, birth cohort study. The aim of this study was to identify whether there is any hidden burden of disease associated with…”
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11
Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis
Published in Rheumatology (Oxford, England) (06-04-2021)“…Abstract Objectives How insulin-like growth factor-1 (IGF-1) is related to OA is not well understood. We determined relationships between IGF-1 and…”
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12
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Published in PLoS genetics (01-07-2012)“…We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide…”
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13
The Effect of Plasma Lipids and Lipid‐Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study
Published in Journal of bone and mineral research (01-07-2020)“…ABSTRACT Several epidemiological studies have reported a relationship between statin treatment and increased bone mineral density (BMD) and reduced fracture…”
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14
Machine Learning–Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank
Published in Journal of bone and mineral research (01-09-2022)“…ABSTRACT The contribution of shape changes to hip osteoarthritis (HOA) remains unclear, as is the extent to which these vary according to HOA severity. In the…”
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15
Association Between Components of Body Composition and Scoliosis: A Prospective Cohort Study Reporting Differences Identifiable Before the Onset of Scoliosis
Published in Journal of bone and mineral research (01-08-2014)“…ABSTRACT There is an increasing body of research suggesting that low body weight is associated with scoliosis, but this is based on case‐control studies, which…”
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Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age
Published in JAMA network open (02-08-2019)“…Bone health in early life is thought to influence the risk of osteoporosis in later life. To examine whether puberty timing is associated with bone mineral…”
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Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: Results from a population-based study of adolescents
Published in Journal of bone and mineral research (01-09-2012)“…Whether a certain level of impact needs to be exceeded for physical activity (PA) to benefit bone accrual is currently unclear. To examine this question, we…”
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18
Motor Competence in Early Childhood Is Positively Associated With Bone Strength in Late Adolescence
Published in Journal of bone and mineral research (01-05-2016)“…ABSTRACT The onset of walking in early childhood results in exposure of the lower limb to substantial forces from weight bearing activity that ultimately…”
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19
Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes
Published in Bone (New York, N.Y.) (01-09-2018)“…Generalised high bone mass (HBM), associated with features of a mild skeletal dysplasia, has a prevalence of 0.18% in a UK DXA-scanned adult population. We…”
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Association Between Bone Mass and Fractures in Children: A Prospective Cohort Study
Published in Journal of bone and mineral research (01-09-2006)“…This is the first prospective cohort study of the association between bone mass and fracture risk in childhood. A total of 6213 children 9.9 years of age were…”
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