Search Results - "Tobias, A.M."

Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization by Sib, Anna, Gulder, Tobias A. M.

“…Natural products are a virtually inexhaustible source of small molecules with spectacular molecular architectures and biomedical potential. Their structural…”
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The Biocatalytic Repertoire of Natural Biaryl Formation by Aldemir, Hülya, Richarz, René, Gulder, Tobias A. M.

“…The catalytic and selective construction of carbon–carbon bonds for the generation of complex molecules is one of the most important tasks in organic…”
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Chemo‐enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)‐Epoxysorbicillinol by Sib, Anna, Gulder, Tobias A. M.

“…The sorbicillinoids are a large family of fungal natural products, many of which possess highly challenging molecular architectures. Depending on their…”
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Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. coli by Antosch, Janine, Schaefers, Françoise, Gulder, Tobias A. M.

“…Polycyclic tetramate macrolactams (PTMs) are a family of biomedically promising natural products with challenging molecular frameworks. Despite these…”
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Biocatalytic Total Synthesis of Ikarugamycin by Greunke, Christian, Glöckle, Anna, Antosch, Janine, Gulder, Tobias A. M.

“…Nature provides an inexhaustible diversity of small organic molecules with beautiful molecular architectures that have strong and selective inhibitory…”
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Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate‐Directed Formation of Quinolones versus Quinazolinones by Einsiedler, Manuel, Jamieson, Cooper S., Maskeri, Mark A., Houk, Kendall N., Gulder, Tobias A. M.

“…Previous studies showed that the FeII/α‐ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus…”
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A Pericyclic Reaction Cascade in Leporin Biosynthesis by Glöckle, Anna, Gulder, Tobias A. M.

“…All roads lead to Rome: The biosynthesis of the leporins in Aspergillus sp. involves an unprecedented pericyclic reaction cascade. The enzyme LepI directs the…”
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Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N‐Methylation in Omphalotin Biosynthesis by Aldemir, Hülya, Gulder, Tobias A. M.

“…Tail‐Me: The N‐methylation of backbone amide bonds in peptide natural products was thought to be exclusive to non‐ribosomal peptides. A newly discovered…”
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Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes by Kundert, Jana, Gulder, Tobias A. M.

“…For a change: Enoyl‐CoA carboxylase/reductases (ECRs) catalyze the selective α‐carboxylation of α,β‐unsaturated CoA‐thioesters. Structure‐based engineering of…”
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Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential by Sib, Anna, Milzarek, Tobias M., Herrmann, Alexander, Oubraham, Lila, Müller, Jonas I., Pichlmair, Andreas, Brack‐Werner, Ruth, Gulder, Tobias A. M.

“…Sorbicillinoids are fungal polyketides characterized by highly complex and diverse molecular structures, with considerable stereochemical intricacy combined…”
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Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties by Mojicevic, Marija, D'Agostino, Paul M., Pavic, Aleksandar, Vojnovic, Sandra, Senthamaraikannan, Ramsankar, Vasiljevic, Branka, Gulder, Tobias A. M., Nikodinovic‐Runic, Jasmina

“…Applying a bioactivity‐guided isolation approach, staurosporine was separated and identified as the active principle in the culture extract of the new isolate…”
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Convergence in the biosynthesis of acetogenic natural products from plants, fungi, and bacteria by Bringmann, Gerhard, Irmer, Andreas, Feineis, Doris, Gulder, Tobias A.M., Fiedler, Hans-Peter

“…The biosynthesis of chrysophanol and the naphthylisoquinoline alkaloids were investigated. These polyketidic compounds are produced convergently in a…”
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The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain by Bringmann, Gerhard, Lang, Gerhard, Gulder, Tobias A.M., Tsuruta, Hideyuki, Mühlbacher, Jörg, Maksimenka, Katja, Steffens, Stefan, Schaumann, Karsten, Stöhr, Rüdiger, Wiese, Jutta, Imhoff, Johannes F., Perović-Ottstadt, Sanja, Boreiko, Olexandra, Müller, Werner E.G.

“…The saltwater culture of a Penicillium chrysogenum strain isolated from the Mediterranean sponge Ircinia fasciculata yielded three new sorbicillin-derived…”
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Cebulactams A1 and A2, new macrolactams isolated from Saccharopolyspora cebuensis, the first obligate marine strain of the genus Saccharopolyspora by Pimentel-Elardo, Sheila Marie, Gulder, Tobias A.M., Hentschel, Ute, Bringmann, Gerhard

“…The new macrolactams cebulactams A1 and A2 were isolated from an extract of the first obligate marine strain of the genus Saccharopolyspora. Their…”
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New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities by Pimentel-Elardo, Sheila M, Buback, Verena, Gulder, Tobias A M, Bugni, Tim S, Reppart, Jason, Bringmann, Gerhard, Ireland, Chris M, Schirmeister, Tanja, Hentschel, Ute

“…Four new tetromycin derivatives, tetromycins 1-4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001(T) cultivated…”
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Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14 by Bringmann, Gerhard, Lang, Gerhard, Maksimenka, Katja, Hamm, Andreas, Gulder, Tobias A.M., Dieter, Anke, Bull, Alan T., Stach, James E.M., Kocher, Niko, Müller, Werner E.G., Fiedler, Hans-Peter

“…The isolation and structural elucidation of a novel highly oxygenated angucyclinone bearing an unprecedented ether bridge is described. The compound exhibits…”
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Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products by Bringmann, Gerhard, Gulder, Tanja, Gulder, Tobias A. M, Breuning, Matthias

“…Axially chiral natural biaryls are examined. These secondary metabolites have many potential uses in drugs…”
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Biosynthetic strategies for tetramic acid formation by Mo, Xuhua, Gulder, Tobias A M

“…Covering: up to the end of 2020Natural products bearing tetramic acid units as part of complex molecular architectures exhibit a broad range of potent…”
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Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics by Gulder, Tobias A. M., Moore, Bradley S.

“…Proteasome inhibitors are rapidly evolving as potent treatment options in cancer therapy. One of the most promising drug candidates of this type is…”
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Discovery of extended product structural space of the fungal dioxygenase AsqJ by Einsiedler, Manuel, Gulder, Tobias A. M.

“…The fungal dioxygenase AsqJ catalyses the conversion of benzo[1,4]diazepine-2,5-diones into quinolone antibiotics. A second, alternative reaction pathway leads…”
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