Search Results - "Tobi, Elmar W."

DNA methylation signatures link prenatal famine exposure to growth and metabolism by Tobi, Elmar W., Goeman, Jelle J., Monajemi, Ramin, Gu, Hongcang, Putter, Hein, Zhang, Yanju, Slieker, Roderick C., Stok, Arthur P., Thijssen, Peter E., Müller, Fabian, van Zwet, Erik W., Bock, Christoph, Meissner, Alexander, Lumey, L. H., Eline Slagboom, P., Heijmans, Bastiaan T.

“…Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the…”
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Persistent epigenetic differences associated with prenatal exposure to famine in humans by Heijmans, Bastiaan T, Tobi, Elmar W, Stein, Aryeh D, Putter, Hein, Blauw, Gerard J, Susser, Ezra S, Slagboom, P. Eline, Lumey, L.H

“…Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the…”
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DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific by Tobi, Elmar W., Lumey, L.H., Talens, Rudolf P., Kremer, Dennis, Putter, Hein, Stein, Aryeh D., Slagboom, P. Eline, Heijmans, Bastiaan T.

“…Prenatal famine in humans has been associated with various later-life consequences, depending on the gestational timing of the insult and the sex of the…”
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Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome by Tobi, Elmar W, Slieker, Roderick C, Stein, Aryeh D, Suchiman, H Eka D, Slagboom, P Eline, van Zwet, Erik W, Heijmans, Bastiaan T, Lumey, L H

“…The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring. Human studies have…”
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Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology by Talens, Rudolf P., Boomsma, Dorret I., Tobi, Elmar W., Kremer, Dennis, Jukema, J. Wouter, Willemsen, Gonneke, Putter, Hein, Slagboom, P. Eline, Heijmans, Bastiaan T.

“…ABSTRACTThe prospect of finding epigenetic risk factors for complex diseases would be greatly enhanced if DNA from existing biobanks, which is generally…”
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DNA Methylation Landscapes of Human Fetal Development by Slieker, Roderick C, Roost, Matthias S, van Iperen, Liesbeth, Suchiman, H Eka D, Tobi, Elmar W, Carlotti, Françoise, de Koning, Eelco J P, Slagboom, P Eline, Heijmans, Bastiaan T, Chuva de Sousa Lopes, Susana M

“…Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human…”
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Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19 by Tobi, Elmar W, Slagboom, P Eline, van Dongen, Jenny, Kremer, Dennis, Stein, Aryeh D, Putter, Hein, Heijmans, Bastiaan T, Lumey, L H

“…Both the early environment and genetic variation may affect DNA methylation, which is one of the major molecular marks of the epigenome. The combined effect of…”
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Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases by Taeubert, M Jazmin, Kuipers, Thomas B, Zhou, Jiayi, Li, Chihua, Wang, Shuang, Wang, Tian, Tobi, Elmar W, Belsky, Daniel W, Lumey, L H, Heijmans, Bastiaan T

“…Exposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear…”
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The epigenome: Archive of the prenatal environment by Heijmans, Bastiaan T., Tobi, Elmar W., Lumey, L.H., Slagboom, P. Eline

“…World-wide, research initiatives are in progress to establish the role of the epigenome in human disease. Empirical data are still scarce, but particularly…”
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Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments by Tobi, Elmar W., van den Heuvel, Joost, Zwaan, Bas J., Lumey, L.H., Heijmans, Bastiaan T., Uller, Tobias

“…An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediated by epigenomic marks,…”
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Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus by Heijmans, Bastiaan T., Kremer, Dennis, Tobi, Elmar W., Boomsma, Dorret I., Slagboom, P. Eline

“…Epigenetic variation may significantly contribute to the risk of common disease. Currently, little is known about the extent and causes of epigenetic…”
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Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER by Suchiman, H Eka D, Slieker, Roderick C, Kremer, Dennis, Slagboom, P Eline, Heijmans, Bastiaan T, Tobi, Elmar W

“…EpiTYPER® is a mass spectrometry-based bisulfite sequencing method that enables region-specific DNA methylation analysis in a quantitative and high-throughput…”
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Tea and coffee consumption in relation to DNA methylation in four European cohorts by Ek, Weronica E, Tobi, Elmar W, Ahsan, Muhammad, Lampa, Erik, Ponzi, Erica, Kyrtopoulos, Soterios A, Georgiadis, Panagiotis, Lumey, L H, Heijmans, Bastiaan T, Botsivali, Maria, Bergdahl, Ingvar A, Karlsson, Torgny, Rask-Andersen, Mathias, Palli, Domenico, Ingelsson, Erik, Hedman, Åsa K, Nilsson, Lena M, Vineis, Paolo, Lind, Lars, Flanagan, James M, Johansson, Åsa

“…Lifestyle factors, such as food choices and exposure to chemicals, can alter DNA methylation and lead to changes in gene activity. Two such exposures with…”
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Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species by Feiner, Nathalie, Radersma, Reinder, Vasquez, Louella, Ringnér, Markus, Nystedt, Björn, Raine, Amanda, Tobi, Elmar W., Heijmans, Bastiaan T., Uller, Tobias

“…Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains…”
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DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age by Tobi, Elmar W., Heijmans, Bastiaan T., Kremer, Dennis, Putter, Hein, Delemarre-van de Waal, Henriette A., Finken, Martijn J.J., Wit, Jan M., Slagboom, P. Eline

“…Being born small for gestational age (SGA), a proxy for intrauterine growth restriction (IUGR), and prenatal famine exposure are both associated with a greater…”
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MethylAid: visual and interactive quality control of large Illumina 450k datasets by van Iterson, Maarten, Tobi, Elmar W, Slieker, Roderick C, den Hollander, Wouter, Luijk, René, Slagboom, P Eline, Heijmans, Bastiaan T

“…The Illumina 450k array is a frequently used platform for large-scale genome-wide DNA methylation studies, i.e. epigenome-wide association studies. Currently,…”
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The effect of the Chinese Famine on type 2 diabetes mellitus epidemics by Li, Chihua, Tobi, Elmar W., Heijmans, Bastiaan T., Lumey, L. H.

“…The Chinese Famine has been widely interpreted as an important contributor to subsequent epidemics of type 2 diabetes mellitus. Our re-examination of available…”
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Accelerated biological aging six decades after prenatal famine exposure by Cheng, Mengling, Conley, Dalton, Kuipers, Tom, Li, Chihua, Ryan, Calen P, Taeubert, M Jazmin, Wang, Shuang, Wang, Tian, Zhou, Jiayi, Schmitz, Lauren L, Tobi, Elmar W, Heijmans, Bas, Lumey, L H, Belsky, Daniel W

“…To test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS,…”
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Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation by Küpers, Leanne K, Fernández-Barrés, Sílvia, Mancano, Giulia, Johnson, Laura, Ott, Raffael, Vioque, Jesus, Colombo, Marco, Landgraf, Kathrin, Tobi, Elmar W, Körner, Antje, Gaillard, Romy, de Vries, Jeanne H M, Jaddoe, Vincent W V, Vrijheid, Martine, Sharp, Gemma C, Felix, Janine F

“…Suboptimal nutrition in pregnancy is associated with worse offspring cardiometabolic health. DNA methylation may be an underlying mechanism. We meta-analyzed…”
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Epigenetic signature of birth weight discordance in adult twins by Tan, Qihua, Frost, Morten, Heijmans, Bastiaan T, von Bornemann Hjelmborg, Jacob, Tobi, Elmar W, Christensen, Kaare, Christiansen, Lene

“…A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal…”
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