Search Results - "Tobey, N. A."

Dilated Intercellular Spaces and Shunt Permeability in Nonerosive Acid-Damaged Esophageal Epithelium by TOBEY, N. A, HOSSEINI, S. S, ARGOTE, C. M, DOBRUCALI, A. M, AWAYDA, M. S, ORLANDO, R. C

“…It has recently been established that patients with nonerosive reflux disease have on biopsy within esophageal epithelium a lesion known as dilated…”
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Dilated intercellular spaces: A morphological feature of acid reflux-- damaged human esophageal epithelium by Tobey, NA, Carson, JL, Alkiek, RA, Orlando, RC

“…BACKGROUND & AIMS: Dilated intercellular spaces are a sign of epithelial damage in acid-perfused rabbit esophagus, a change best identified by transmission…”
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Electrical parameters and ion species for active transport in human esophageal stratified squamous epithelium and Barrett's specialized columnar epithelium by Tobey, N A, Argote, C M, Vanegas, X C, Barlow, W, Orlando, R C

“…The human esophagus is lined by stratified squamous epithelium (ESSE), and in some subjects with reflux disease the distal esophagus becomes lined by Barrett's…”
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Physicochemical basis for dilated intercellular spaces in non-erosive acid-damaged rabbit esophageal epithelium by Tobey, N. A., Gambling, T. M., Vanegas, X. C., Carson, J. L., Orlando, R. C.

“…SUMMARY Dilated intercellular spaces (DIS) within esophageal epithelium (EE) is a histopathologic feature of non‐erosive reflux disease and early lesion in…”
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Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium by Tobey, N A, Argote, C M, Hosseini, S S, Orlando, R C

“…The Ca(2+)-switch technique was used to investigate the nature of the barrier governing (paracellular) permeability across the junctions of "native" rabbit…”
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Physiological and morphological effects of alendronate on rabbit esophageal epithelium by Dobrucali, A, Tobey, N A, Awayda, M S, Argote, C, Abdulnour-Nakhoul, S, Shao, W, Orlando, R C

“…Alendronate, an aminobisphosphonate, produces as a side effect a topical (pill induced) esophagitis. To gain insight into this phenomenon, we assessed the…”
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Human esophageal epithelial cells possess an Na+/H+ exchanger for H+ extrusion by Tobey, Nelia A, Koves, Gabor, Orlando, Roy C

“…The human esophagus is regularly exposed to refluxed gastric acid. Therefore, its epithelial cells require for survival a means of extruding excess H+ from the…”
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Esophageal exposure to ethanol increases risk of acid damage in rabbit esophagus by BOR, S, BOR-CAYMAZ, C, TOBEY, N. A, ABDULNOUR-NAKHOUL, S, ORLANDO, R. C

“…Heavy alcohol consumption is associated with the development of reflux esophagitis. Among the reasons for this are impairment of the antireflux barrier,…”
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Altered intestinal chloride transport in cystic fibrosis by Berschneider, H M, Knowles, M R, Azizkhan, R G, Boucher, R C, Tobey, N A, Orlando, R C, Powell, D W

“…Sodium ion and chloride transport was studied in vitro in small intestinal and colonic tissue from patients with cystic fibrosis (CF) and from non-CF control…”
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Effect of luminal acidity on the apical cation channel in rabbit esophageal epithelium by Tobey, N A, Argote, C M, Awayda, M S, Vanegas, X C, Orlando, R C

“…Esophageal epithelial cells contain an apical cation channel that actively absorbs sodium ions (Na(+)). Since these channels are exposed in vivo to acid…”
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HCl-induced cell edema in primary cultured rabbit esophageal epithelium by Tobey, NA, Koves, G, Orlando, RC

“…BACKGROUND & AIMS: In a prior study, esophageal epithelial cells within intact epithelium were observed to swell after exposure to low extracellular pH (pHo)…”
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How does the esophageal epithelium maintain its integrity? by Tobey, N A

“…The esophageal epithelium maintains its integrity by both structural and functional epithelial defenses. Structural components are cell membranes and…”
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Barriers to paracellular permeability in rabbit esophageal epithelium by Orlando, R C, Lacy, E R, Tobey, N A, Cowart, K

“…Morphological and electrophysiological techniques were used to define the location and nature of the barriers to diffusion across the intercellular space…”
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Mechanisms of acid injury to rabbit esophageal epithelium. Role of basolateral cell membrane acidification by Tobey, N A, Orlando, R C

“…Because mucosal HCl traverses the paracellular pathway before significant damage develops within esophageal epithelium, the effects of mucosal and serosal…”
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Serosal bicarbonate protects against acid injury to rabbit esophagus by Tobey, N A, Powell, D W, Schreiner, V J, Orlando, R C

“…The role of serosal bicarbonate ions (HCO3-) in protection against acid injury was investigated in rabbit esophageal mucosa mounted in Ussing chambers. Luminal…”
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Effects of luminal hypertonicity on rabbit esophageal epithelium by Long, J D, Marten, E, Tobey, N A, Orlando, R C

“…The human esophagus is exposed daily to luminal contents that are hypertonic with respect to blood. Because the effects of such exposure are unknown, we…”
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The role of pepsin in acid injury to esophageal epithelium by Tobey, Nelia A, Hosseini, Seraj S, Caymaz-Bor, Canan, Wyatt, Holly R, Orlando, Geraldine S, Orlando, Roy C

“…The development of reflux esophagitis in humans is a process resulting from esophageal exposure to refluxed gastric contents. There is no doubt that damage to…”
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Systemic factors in esophageal mucosal protection by Tobey, N A

“…Blood bicarbonate is an important systemic factor in esophageal protection due to its capacity for buffering H+ either in the lumen, at the epithelial surface,…”
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Why does sucralfate improve healing in reflux esophagitis? The role of sucrose octasulfate by Orlando, R C, Tobey, N A

“…In the present investigation, one of sucralfate's major components, sucrose octasulfate (SOS), is shown in vitro to protect human esophageal epithelium against…”
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280 EFFECT OF LYE (NaOH) EXPOSURE ON THE PERMEABILITY OF RABBIT ESOPHAGEAL EPITHELIUM by Atug, O., Dobrucali, A. M., Tobey, N. A., Orlando, R. C.

“…Aim/BackgroundWe previously reported that lye (NaOH) injury (Gastroenterology 1991;100:A128) to esophageal epithelium was time and concentration dependent, as…”
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