Search Results - "Tober, Kathleen L."

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations by Cooperstone, Jessica L., Tober, Kathleen L., Riedl, Ken M., Teegarden, Matthew D., Cichon, Morgan J., Francis, David M., Schwartz, Steven J., Oberyszyn, Tatiana M.

“…Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are…”
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Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane by Bricker, Gregory V, Riedl, Kenneth M, Ralston, Robin A, Tober, Kathleen L, Oberyszyn, Tatiana M, Schwartz, Steven J

“…SCOPE: Broccoli sprouts are a rich source of glucosinolates, a group of phytochemicals that when hydrolyzed, are associated with cancer prevention. Our…”
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Gender differences in UVB-induced skin carcinogenesis, inflammation, and DNA damage by THOMAS-AHNER, Jennifer M, WUIFF, Brian C, TOBER, Kathleen L, KUSEWITT, Donna F, RIGGENBACH, Judy A, OBERYSZYN, Tatiana M

“…The American Cancer Society reports the incidence of squamous cell carcinoma in males to be thrice the incidence in females. This increased squamous cell…”
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Differential effects of topical vitamin E and C E Ferulic® treatments on ultraviolet light B-induced cutaneous tumor development in Skh-1 mice by Burns, Erin M, Tober, Kathleen L, Riggenbach, Judith A, Kusewitt, Donna F, Young, Gregory S, Oberyszyn, Tatiana M

“…Because of the ever-increasing incidence of ultraviolet light B (UVB)-induced skin cancer, considerable attention is being paid to prevention through the use…”
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UV Light B–Mediated Inhibition of Skin Catalase Activity Promotes Gr-1+CD11b+ Myeloid Cell Expansion by Sullivan, Nicholas J., Tober, Kathleen L., Burns, Erin M., Schick, Jonathan S., Riggenbach, Judith A., Mace, Thomas A., Bill, Matthew A., Young, Gregory S., Oberyszyn, Tatiana M., Lesinski, Gregory B.

“…Skin cancer incidence and mortality are higher in men compared with women, but the causes of this sex discrepancy remain largely unknown. UV light exposure…”
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Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice by Hill, Natasha T, Gracia-Maldonado, Gabriel H, Leonard, Mary K, Harper, Amanda R, Tober, Kathleen L, Oberyszyn, Tatiana M, Kadakia, Madhavi P

“…ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase…”
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Importance of the EP1 Receptor in Cutaneous UVB-Induced Inflammation and Tumor Development by Tober, Kathleen L., Wilgus, Traci A., Kusewitt, Donna F., Thomas-Ahner, Jennifer M., Maruyama, Takayuki, Oberyszyn, Tatiana M.

“…Chronic exposure to UV light, the primary cause of skin cancer, results in the induction of high levels of cyclooxygenase-2 (COX-2) expression in the skin. The…”
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The Impact of Cyclooxygenase-2 Mediated Inflammation on Scarless Fetal Wound Healing by Wilgus, Traci A., Bergdall, Valerie K., Tober, Kathleen L., Hill, Kara J., Mitra, Srabani, Flavahan, Nicholas A., Oberyszyn, Tatiana M.

“…Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological processes…”
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Effects of UVB on E Prostanoid Receptor Expression in Murine Skin by Tober, Kathleen L., Thomas-Ahner, Jennifer M., Kusewitt, Donna F., Oberyszyn, Tatiana M.

“…Prostaglandin E2 (PGE2) upregulation in response to UV light exposure is a significant factor in the development of non-melanoma skin cancer. It is known that…”
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Possible cross-regulation of the E prostanoid receptors by Tober, Kathleen L., Thomas-Ahner, Jennifer M., Maruyama, Takayuki, Oberyszyn, Tatiana M.

“…Exposure to UVB induces an inflammatory response in the skin that results in high levels of cyclooxygenase‐2 (COX‐2) and its enzymatic product, prostaglandin…”
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Ultraviolet radiation accelerates NRas‐mutant melanomagenesis: A cooperative effect blocked by sunscreen by Hennessey, Rebecca C., Holderbaum, Andrea M., Bonilla, Anamaria, Delaney, Conor, Gillahan, James E., Tober, Kathleen L., Oberyszyn, Tatiana M., Zippin, Jonathan H., Burd, Christin E.

“…Summary To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test…”
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Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma by Riggenbach, Judith A., Burns, Erin M., Oberyszyn, Tatiana M., Young, Gregory S., Kusewitt, Donna F., Tober, Kathleen L.

“…Epidemiological studies support a link between cumulative sun exposure and cutaneous squamous cell carcinoma (SCC) development. However, the presumed effects…”
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25-Hydroxyvitamin D 3 and its C-3 epimer are elevated in the skin and serum of Skh-1 mice supplemented with dietary vitamin D 3 by Teegarden, Matthew D, Campbell, Amanda R, Cooperstone, Jessica L, Tober, Kathleen L, Schwartz, Steven J, Oberyszyn, Tatiana M

“…UV exposure is a risk factor for keratinocyte carcinoma (KC) while critical for endogenous vitamin D production. We investigated dietary modulation of skin and…”
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25‐Hydroxyvitamin D3 and its C‐3 epimer are elevated in the skin and serum of Skh‐1 mice supplemented with dietary vitamin D3 by Teegarden, Matthew D., Campbell, Amanda R., Cooperstone, Jessica L., Tober, Kathleen L., Schwartz, Steven J., Oberyszyn, Tatiana M.

“…Scope UV exposure is a risk factor for keratinocyte carcinoma (KC) while critical for endogenous vitamin D production. We investigated dietary modulation of…”
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Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of tangerine tomatoes by Kopec, Rachel E., Schick, Jonathan, Tober, Kathleen L., Riedl, Ken M., Francis, David M., Young, Gregory S., Schwartz, Steven J., Oberyszyn, Tatiana M.

“…Scope UVB exposure, a major factor in the development of skin cancer, has differential sex effects. Tomato product consumption reduces the intensity of…”
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Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22 by Abikhair, Melody, Mitsui, Hiroshi, Yanofsky, Valerie, Roudiani, Nazanin, Ovits, Channa, Bryan, Teddy, Oberyszyn, Tatiana M, Tober, Kathleen L, Gonzalez, Juana, Krueger, James G, Felsen, Diane, Carucci, John A

“…Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors,…”
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MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma by Nagarajan, Priyadharsini, Tober, Kathleen L, Riggenbach, Judith A, Kusewitt, Donna F, Lehman, Amy M, Sielecki, Thais, Pruitt, James, Satoskar, Abhay R, Oberyszyn, Tatiana M

“…Macrophage migration inhibitory factor (MIF) is a homotrimeric proinflammatory cytokine implicated in chronic inflammatory diseases and malignancies, including…”
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Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma by Burns, Erin M, Tober, Kathleen L, Riggenbach, Judith A, Schick, Jonathan S, Lamping, Keith N, Kusewitt, Donna F, Young, Gregory S, Oberyszyn, Tatiana M

“…Ultraviolet B (UVB) light is the major environmental carcinogen contributing to non-melanoma skin cancer (NMSC) development. There are over 3.5 million NMSC…”
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Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation by Duncan, F J, Martin, Jason R, Wulff, Brian C, Stoner, Gary D, Tober, Kathleen L, Oberyszyn, Tatiana M, Kusewitt, Donna F, Van Buskirk, Anne M

“…Light in the UVB spectrum (280-320 nm) induces a number of changes in the epidermis and dermis of mice and humans, resulting in a robust inflammatory response…”
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Slug Expression in Mouse Skin and Skin Tumors Is Not Regulated by p53 by Perez, Carlos J., Rundhaug, Joyce E., Johnson, David G., Oberyszyn, Tatiana M., Tober, Kathleen L., Kusewitt, Donna F.

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