Search Results - "Toba, Shiori"

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans by Yan, Jing, Chao, Dan L, Toba, Shiori, Koyasako, Kotaro, Yasunaga, Takuo, Hirotsune, Shinji, Shen, Kang

“…In neurons, microtubules (MTs) span the length of both axons and dendrites, and the molecular motors use these intracellular 'highways' to transport diverse…”
Get full text

Overlapping Hand-over-Hand Mechanism of Single Molecular Motility of Cytoplasmic Dynein by Toba, Shiori, Watanabe, Tomonobu M., Yamaguchi-Okimoto, Lisa, Toyoshima, Yoko Yano, Higuchi, Hideo

“…Structural differences between dynein and kinesin suggest a unique molecular mechanism of dynein motility. Measuring the mechanical properties of a single…”
Get full text

X-Ray Fiber Diffraction Recordings from Oriented Demembranated Chlamydomonas Flagellar Axonemes by Toba, Shiori, Iwamoto, Hiroyuki, Kamimura, Shinji, Oiwa, Kazuhiro

“…The high homology of its axonemal components with humans and a large repertoire of axonemal mutants make Chlamydomonas a useful model system for experiments on…”
Get full text

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein by Yamada, Masami, Toba, Shiori, Yoshida, Yuko, Haratani, Koji, Mori, Daisuke, Yano, Yoshihisa, Mimori-Kiyosue, Yuko, Nakamura, Takeshi, Itoh, Kyoko, Fushiki, Shinji, Setou, Mitsutoshi, Wynshaw-Boris, Anthony, Torisawa, Takayuki, Toyoshima, Yoko Y, Hirotsune, Shinji

“…LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1 is required for dynein activity, but the underlying mechanism is…”
Get full text

Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules by Toba, Shiori, Koyasako, Kotaro, Yasunaga, Takuo, Hirotsune, Shinji

“…Cytoplasmic dynein is a microtubule-based motor protein that transports intracellular cargo and performs various functions during cell division. We previously…”
Get full text

Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization by Takitoh, Takako, Kumamoto, Kanako, Wang, Chen-Chi, Sato, Makoto, Toba, Shiori, Wynshaw-Boris, Anthony, Hirotsune, Shinji

“…Neuronal migration is a critical feature to ensure proper location and wiring of neurons during cortical development. Postmitotic neurons migrate from the…”
Get full text

A unique role of dynein and nud family proteins in corticogenesis by Toba, Shiori, Hirotsune, Shinji

“…Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of…”
Get full text

Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement by Yamada, Masami, Kumamoto, Kanako, Mikuni, Shintaro, Arai, Yoshiyuki, Kinjo, Masataka, Nagai, Takeharu, Tsukasaki, Yoshikazu, Watanabe, Tomonobu M, Fukui, Mitsuru, Jin, Mingyue, Toba, Shiori, Hirotsune, Shinji

“…Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules. We previously demonstrated that LIS1 forms an idling…”
Get full text

mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1 by Yamada, Masami, Toba, Shiori, Takitoh, Takako, Yoshida, Yuko, Mori, Daisuke, Nakamura, Takeshi, Iwane, Atsuko H, Yanagida, Toshio, Imai, Hiroshi, Yu-Lee, Li-yuan, Schroer, Trina, Wynshaw-Boris, Anthony, Hirotsune, Shinji

“…Lissencephaly is a devastating neurological disorder caused by defective neuronal migration. The LIS1 (or PAFAH1B1 ) gene was identified as the gene mutated in…”
Get full text

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly by Toba, Shiori, Tamura, Yasuhisa, Kumamoto, Kanako, Yamada, Masami, Takao, Keizo, Hattori, Satoko, Miyakawa, Tsuyoshi, Kataoka, Yosky, Azuma, Mitsuyoshi, Hayasaka, Kiyoshi, Amamoto, Masano, Tominaga, Keiko, Wynshaw-Boris, Anthony, Wanibuchi, Hideki, Oka, Yuichiro, Sato, Makoto, Kato, Mitsuhiro, Hirotsune, Shinji

“…Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued…”
Get full text

X-ray diffraction recording from single axonemes of eukaryotic flagella by Nishiura, Masaya, Toba, Shiori, Takao, Daisuke, Miyashiro, Daisuke, Sakakibara, Hitoshi, Matsuo, Tatsuhito, Kamimura, Shinji, Oiwa, Kazuhiro, Yagi, Naoto, Iwamoto, Hiroyuki

“…We report the first X-ray diffraction patterns recorded from single axonemes of eukaryotic flagella with a diameter of only <0.2μm, by using the technique of…”
Get full text

Biophysical Measurements on Axonemal Dyneins by Kojima, Hiroaki, Toba, Shiori, Sakakibara, Hitoshi, Oiwa, Kazuhiro

“…In recent decades, the development of technologies such as optical trap nanometry and advanced fluorescence microscopy have provided tools for studying the…”
Get full text

Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport by Toba, Shiori, Jin, Mingyue, Yamada, Masami, Kumamoto, Kanako, Matsumoto, Sakiko, Yasunaga, Takuo, Fukunaga, Yuko, Miyazawa, Atsuo, Fujita, Sakiko, Itoh, Kyoko, Fushiki, Shinji, Kojima, Hiroaki, Wanibuchi, Hideki, Arai, Yoshiyuki, Nagai, Takeharu, Hirotsune, Shinji

“…Although α-synuclein (αSyn) has been linked to Parkinson’s disease (PD), the mechanisms underlying the causative role in PD remain unclear. We previously…”
Get full text

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics by Jin, Mingyue, Pomp, Oz, Shinoda, Tomoyasu, Toba, Shiori, Torisawa, Takayuki, Furuta, Ken’ya, Oiwa, Kazuhiro, Yasunaga, Takuo, Kitagawa, Daiju, Matsumura, Shigeru, Miyata, Takaki, Tan, Thong Teck, Reversade, Bruno, Hirotsune, Shinji

“…Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly…”
Get full text

Publisher Correction: Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport by Toba, Shiori, Jin, Mingyue, Yamada, Masami, Kumamoto, Kanako, Matsumoto, Sakiko, Yasunaga, Takuo, Fukunaga, Yuko, Miyazawa, Atsuo, Fujita, Sakiko, Itoh, Kyoko, Fushiki, Shinji, Kojima, Hiroaki, Wanibuchi, Hideki, Arai, Yoshiyuki, Nagai, Takeharu, Hirotsune, Shinji

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
Get full text

Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 of Chlamydomonas flagella by Toba, Shiori, Fox, Laura A., Sakakibara, Hitoshi, Porter, Mary E., Oiwa, Kazuhiro, Sale, Winfield S.

“…The Chlamydomonas I1 dynein is a two-headed inner dynein arm important for the regulation of flagellar bending. Here we took advantage of mutant strains…”
Get full text

PB-09Alpha-synuclein Binds Unconventional Microtubules That Have a Unique Function by Toba, Shiori, Jin, Mingyue, Yamada, Masami, Matsumoto, Sakiko, Yasunaga, Takuo, Fukunaga, Yuko, Miyazawa, Atsuo, Kojima, Hiroaki, Arai, Yoshiyuki, Nagai, Takeharu, Hirotsune, Shinji

Get full text

Dynein and kinesin share an overlapping microtubule-binding site by Mizuno, Naoko, Toba, Shiori, Edamatsu, Masaki, Watai-Nishii, Junko, Hirokawa, Nobutaka, Toyoshima, Yoko Y, Kikkawa, Masahide

“…Dyneins and kinesins move in opposite directions on microtubules. The question of how the same‐track microtubules are able to support movement in two…”
Get full text

Direction and speed of microtubule movements driven by kinesin motors arranged on catchin thick filaments by Taba, Toshiki, Edamatsu, Masaki, Toba, Shiori, Shibata, Keitaro, Imafuku, Yasuhiro, Toyoshima, Yoko Yano, Tawada, Katsuhisa, Yamada, Akira

“…Conventional kinesin (Kinesin‐1) is a microtubule‐based molecular motor that supports intracellular vesicle/organelle transport in various eukaryotic cells. To…”
Get full text

Properties of the full-length heavy chains of Tetrahymena ciliary outer arm dynein separated by urea treatment by Toba, Shiori, Gibson, Tracie M., Shiroguchi, Katsuyuki, Toyoshima, Yoko Y., Asai, David J.

“…An important challenge is to understand the functional specialization of dynein heavy chains. The ciliary outer arm dynein from Tetrahymena thermophila is a…”
Get full text