Search Results - "Törner, Ricarda"

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1 by Guzik, Katarzyna, Zak, Krzysztof M, Grudnik, Przemyslaw, Magiera, Katarzyna, Musielak, Bogdan, Törner, Ricarda, Skalniak, Lukasz, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A

“…Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based…”
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Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin by Törner, Ricarda, Kupreichyk, Tatsiana, Gremer, Lothar, Debled, Elisa Colas, Fenel, Daphna, Schemmert, Sarah, Gans, Pierre, Willbold, Dieter, Schoehn, Guy, Hoyer, Wolfgang, Boisbouvier, Jerome

“…Chaperones, as modulators of protein conformational states, are key cellular actors to prevent the accumulation of fibrillar aggregates. Here, we integrated…”
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Optimized precursor to simplify assignment transfer between backbone resonances and stereospecifically labelled valine and leucine methyl groups: application to human Hsp90 N-terminal domain by Henot, Faustine, Kerfah, Rime, Törner, Ricarda, Macek, Pavel, Crublet, Elodie, Gans, Pierre, Frech, Matthias, Hamelin, Olivier, Boisbouvier, Jerome

“…Methyl moieties are highly valuable probes for quantitative NMR studies of large proteins. Hence, their assignment is of the utmost interest to obtain…”
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Backbone and methyl resonances assignment of the 87 kDa prefoldin from Pyrococcus horikoshii by Törner, Ricarda, Henot, Faustine, Awad, Rida, Macek, Pavel, Gans, Pierre, Boisbouvier, Jerome

“…Prefoldin is a heterohexameric protein assembly which acts as a co-chaperonin for the well conserved Hsp60 chaperonin, present in archaebacteria and the…”
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Spectral editing of intra- and inter-chain methyl–methyl NOEs in protein complexes by Törner, Ricarda, Awad, Rida, Gans, Pierre, Brutscher, Bernhard, Boisbouvier, Jerome

“…Specific isotopic labeling of methyl groups in a perdeuterated protein background enables the detection of long range NOEs in proteins or high molecular weight…”
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The role of heat shock proteins in preventing amyloid toxicity by Törner, Ricarda, Kupreichyk, Tatsiana, Hoyer, Wolfgang, Boisbouvier, Jerome

“…The oligomerization of monomeric proteins into large, elongated, β-sheet-rich fibril structures (amyloid), which results in toxicity to impacted cells, is…”
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Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F-13C two-dimensional NMR by Suleiman, Motasem, Frere, Geordon A, Törner, Ricarda, Tabunar, Lauren, Bhole, Gaurav Vijay, Taverner, Keith, Tsuchimura, Nobuyuki, Pichugin, Dmitry, Lichtenecker, Roman J, Vozny, Oleksandr, Gunning, Patrick, Arthanari, Haribabu, Sljoka, Adnan, Prosser, Robert S

“…Tryptophan plays a critical role in proteins by contributing to stability, allostery, and catalysis. Using fluorine (19F) nuclear magnetic resonance (NMR),…”
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Mechanism for controlled assembly of transcriptional condensates by Aire by Huoh, Yu-San, Zhang, Qianxia, Törner, Ricarda, Baca, Sylvan C., Arthanari, Haribabu, Hur, Sun

“…Transcriptional condensates play a crucial role in gene expression and regulation, yet their assembly mechanisms remain poorly understood. Here, we report a…”
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Targeting ROS production through inhibition of NADPH oxidases by Reis, Joana, Gorgulla, Christoph, Massari, Marta, Marchese, Sara, Valente, Sergio, Noce, Beatrice, Basile, Lorenzo, Törner, Ricarda, Cox, Huel, Viennet, Thibault, Yang, Moon Hee, Ronan, Melissa M., Rees, Matthew G., Roth, Jennifer A., Capasso, Lucia, Nebbioso, Angela, Altucci, Lucia, Mai, Antonello, Arthanari, Haribabu, Mattevi, Andrea

“…NADPH oxidases (NOXs) are transmembrane enzymes that are devoted to the production of reactive oxygen species (ROS). In cancers, dysregulation of NOX enzymes…”
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Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19 F- 13 C two-dimensional NMR by Suleiman, Motasem, Frere, Geordon A, Törner, Ricarda, Tabunar, Lauren, Bhole, Gaurav Vijay, Taverner, Keith, Tsuchimura, Nobuyuki, Pichugin, Dmitry, Lichtenecker, Roman J, Vozny, Oleksandr, Gunning, Patrick, Arthanari, Haribabu, Sljoka, Adnan, Prosser, Robert S

“…Tryptophan plays a critical role in proteins by contributing to stability, allostery, and catalysis. Using fluorine ( F) nuclear magnetic resonance (NMR),…”
Get full text