Search Results - "To, L. Bik"

How I treat patients who mobilize hematopoietic stem cells poorly by To, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E.

“…Transplantation with 2-5 × 106 mobilized CD34+cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with…”
Get full text

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo by Zeissig, Mara N, Hewett, Duncan R, Panagopoulos, Vasilios, Mrozik, Krzysztof M, To, L Bik, Croucher, Peter I, Zannettino, Andrew C W, Vandyke, Kate

“…Multiple myeloma (MM) disease progression is dependent on the ability of MM plasma cells (PCs) to egress from the bone marrow (BM), enter the circulation and…”
Get full text

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 by Vandyke, Kate, Zeissig, Mara N, Hewett, Duncan R, Martin, Sally K, Mrozik, Krzysztof M, Cheong, Chee Man, Diamond, Peter, To, L Bik, Gronthos, Stan, Peet, Daniel J, Croucher, Peter I, Zannettino, Andrew C W

“…Disease progression and relapse in multiple myeloma is dependent on the ability of the multiple myeloma plasma cells (PC) to reenter the circulation and…”
Get full text

Hematopoietic cell transplantation for primary plasma cell leukemia: results from the Center for International Blood and Marrow Transplant Research by Mahindra, A, Kalaycio, M E, Vela-Ojeda, J, Vesole, D H, Zhang, M-J, Li, P, Berenson, J R, Bird, J M, Dispenzieri, A, Gajewski, J L, Gale, R P, Holmberg, L, Kumar, S, Kyle, R A, Lazarus, H M, Lonial, S, Mikhael, J, Milone, G A, Munker, R, Nath, R, Saccaro, S, To, L Bik, Vogl, D T, Wirk, B, Hari, P

“…There are limited data on hematopoietic cell transplantation (HCT) in primary plasma cell leukemia (pPCL), an aggressive plasma cell disorder. We report…”
Get full text

Dasatinib Cellular Uptake and Efflux in Chronic Myeloid Leukemia Cells: Therapeutic Implications by HIWASE, Devendra K, SAUNDERS, Verity, HUGHES, Timothy P, WHITE, Deborah L, HEWETT, Duncan, FREDE, Amity, ZRIM, Stephanie, DANG, Phuong, EADIE, Laura, BIK TO, L, MELO, Junia, KUMAR, Sharad

“…Purpose: The organic cation transporter OCT-1 mediates active transport of imatinib. We recently showed that low OCT-1 activity is a major contributor to…”
Get full text

An optimized algorithm for detecting and annotating regional differential methylation by Li, Sheng, Garrett-Bakelman, Francine E, Akalin, Altuna, Zumbo, Paul, Levine, Ross, To, Bik L, Lewis, Ian D, Brown, Anna L, D'Andrea, Richard J, Melnick, Ari, Mason, Christopher E

“…DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome that are altered during development or that are perturbed by…”
Get full text

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia by Scott, Hamish S, Hahn, Christopher N, Chong, Chan-Eng, Carmichael, Catherine L, Wilkins, Ella J, Brautigan, Peter J, Li, Xiao-Chun, Babic, Milena, Lin, Ming, Carmagnac, Amandine, Lee, Young K, Kok, Chung H, Gagliardi, Lucia, Friend, Kathryn L, Ekert, Paul G, Butcher, Carolyn M, Brown, Anna L, Lewis, Ian D, To, L Bik, Timms, Andrew E, Storek, Jan, Moore, Sarah, Altree, Meryl, Escher, Robert, Bardy, Peter G, Suthers, Graeme K, D'Andrea, Richard J, Horwitz, Marshall S

“…We report the discovery of GATA2 as a new myelodysplastic syndrome (MDS)-acute myeloid leukemia (AML) predisposition gene. We found the same, previously…”
Get full text

Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis by Vandyke, K, Dewar, A L, Farrugia, A N, Fitter, S, Bik To, L, Hughes, T P, Zannettino, A C W

Get full text

Human Gastrointestinal Neoplasia‐Associated Myofibroblasts Can Develop from Bone Marrow‐Derived Cells Following Allogeneic Stem Cell Transplantation by Worthley, Daniel L., Ruszkiewicz, Andrew, Davies, Ruth, Moore, Sarah, Nivison‐Smith, Ian, Bik To, L., Browett, Peter, Western, Robyn, Durrant, Simon, So, Jason, Young, Graeme P., Mullighan, Charles G., Bardy, Peter G., Michael, Michael Z.

“…This study characterized the contribution of bone marrow‐derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow…”
Get full text

Long-term imatinib therapy promotes bone formation in CML patients by Fitter, Stephen, Dewar, Andrea L., Kostakis, Panagiota, To, L. Bik, Hughes, Timothy P., Roberts, Marion M., Lynch, Kevin, Vernon-Roberts, Barrie, Zannettino, Andrew C.W.

“…Imatinib inhibits tyrosine kinases important in osteoclast (c-Fms) and osteoblast (platelet-derived growth factor receptor [PDGF-R], c-Abl) function,…”
Get full text

GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations by Perugini, M, Iarossi, D G, Kok, C H, Cummings, N, Diakiw, S M, Brown, A L, Danner, S, Bardy, P, Bik To, L, Wei, A H, Lewis, I D, D'Andrea, R J

Get full text

Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma‐Associated Bone Loss by Diamond, Peter, Labrinidis, Agatha, Martin, Sally K, Farrugia, Amanda N, Gronthos, Stan, To, L Bik, Fujii, Nobutaka, O'Loughlin, Peter D, Evdokiou, Andreas, Zannettino, Andrew CW

“…The plasma cell (PC) malignancy, multiple myeloma (MM), is unique among hematological malignancies in its capacity to cause osteoclast (OC)‐mediated skeletal…”
Get full text

Cotransplantation of Placental Mesenchymal Stromal Cells Enhances Single and Double Cord Blood Engraftment in Nonobese Diabetic/Severe Combined Immune Deficient Mice by Hiwase, Smita D, Dyson, Pamela G, To, L. Bik, Lewis, Ian D.

“…Limited cell numbers in a unit restricts cord blood transplantation (CBT) in adults. We evaluated whether cotransplantation of placental mesenchymal stromal…”
Get full text

Measurement of In Vivo BCR-ABL Kinase Inhibition to Monitor Imatinib-Induced Target Blockade and Predict Response in Chronic Myeloid Leukemia by WHITE, Deborah, SAUNDERS, Verity, GRIGG, Andrew, ARTHUR, Chris, FILSHIE, Robin, LEAHY, Michael F, LYNCH, Kevin, BIK TO, L, HUGHES, Timothy

“…Intrinsic sensitivity to imatinib, based on measurement of inhibitory concentration 50% for imatinib, is variable in untreated patients with chronic myeloid…”
Get full text

Imatinib as a potential antiresorptive therapy for bone disease by Dewar, Andrea L., Farrugia, Amanda N., Condina, Mark R., Bik To, L., Hughes, Timothy P., Vernon-Roberts, Barrie, Zannettino, Andrew C.W.

“…Osteoclasts (OCs) are large multinucleated cells derived from progenitor cells of the monocyte-macrophage lineage. Signal transduction via the…”
Get full text

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML by Powell, Jason A., Thomas, Daniel, Barry, Emma F., Kok, Chung H., McClure, Barbara J., Tsykin, Anna, To, L. Bik, Brown, Anna, Lewis, Ian D., Herbert, Kirsten, Goodall, Gregory J., Speed, Terence P., Asou, Norio, Jacob, Bindya, Osato, Motomi, Haylock, David N., Nilsson, Susan K., D'Andrea, Richard J., Lopez, Angel F., Guthridge, Mark A.

“…Deregulated cell survival programs are a classic hallmark of cancer. We have previously identified a serine residue (Ser585) in the βc subunit of the…”
Get full text

Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis by Komrokji, Rami S., Seymour, John F., Roberts, Andrew W., Wadleigh, Martha, To, L. Bik, Scherber, Robyn, Turba, Elyce, Dorr, Andrew, Zhu, Joy, Wang, Lixia, Granston, Tanya, Campbell, Mary S., Mesa, Ruben A.

“…Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1. It demonstrated a favorable…”
Get full text

Dynamic evolution of clonal epialleles revealed by methclone by Li, Sheng, Garrett-Bakelman, Francine, Perl, Alexander E, Luger, Selina M, Zhang, Chao, To, Bik L, Lewis, Ian D, Brown, Anna L, D'Andrea, Richard J, Ross, M Elizabeth, Levine, Ross, Carroll, Martin, Melnick, Ari, Mason, Christopher E

“…We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles)…”
Get full text

Mobilisation strategies for normal and malignant cells by To, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E.J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C., Lewis, Ian D.

“…This review evaluates the latest information on the mobilisation of haemopoietic stem cells for transplantation, with the focus on what is the current best…”
Get full text

Dynamic assessment of RBC‐transfusion dependency improves the prognostic value of the revised‐IPSS in MDS patients by Hiwase, Devendra K., Singhal, Deepak, Strupp, Corinna, Chhetri, Rakchha, Kutyna, Monika M., Wee, L. Amilia, Harrison, Peter B., Nath, Shriram V., Wickham, Nicholas, Hui, Chi‐Hung, Gray, James X., Bardy, Peter, Ross, David M., Lewis, Ian D., Reynolds, John, To, L. Bik, Germing, Ulrich

“…RBC‐transfusion dependency (RBC‐TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification‐based prognostic scoring…”
Get full text