Search Results - "To, Jesi Y"
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Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration
Published in The Journal of biological chemistry (02-02-2018)“…Our recent work uncovered novel roles for activated Gαi signaling in the regulation of neutrophil polarity and adhesion. GαiGTP-mediated enhancement of…”
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Journal Article -
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Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
Published in Science signaling (23-02-2016)“…Activation of the Gi family of heterotrimeric guanine nucleotide-binding proteins (G proteins) releases βγ subunits, which are the major transducers of…”
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Journal Article -
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Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus‐Prone Mice
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-09-2016)“…Objective Despite considerable advances in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for new and more targeted…”
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Journal Article -
4
Inhibition of G Protein beta gamma Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-09-2016)“…Objective Despite considerable advances in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for new and more targeted…”
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Journal Article -
5
Inhibition of G Protein [beta][gamma] Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-09-2016)“…Objective Despite considerable advances in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for new and more targeted…”
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Journal Article -
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The Importance of G Protein Signaling in Immune Cell Function: A Novel Role for Active Gαi in Cell Adhesion and Migration and the Therapeutic Potential of Targeting Gβγ in Inflammation
Published 01-01-2018“…Chemotaxis is the directional movement of cells towards a gradient of chemoattractant such as chemokines. Chemokines are small peptides secreted by various…”
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Dissertation