Search Results - "To, Dennis"

Disulfide stoppered polyrotaxanes with enhanced cellular uptake and intracellular cyclodextrin release by Kali, Gergely, Mayer, Alexander H., To, Dennis, Truszkowska, Martyna, Plangger, Raphael, Gallei, Markus, Bernkop-Schnürch, Andreas

“…Polyrotaxanes are molecular necklaces composed of polymers, threaded macrocycles, and bulky stopper molecules to inhibit the decomposition of the first two…”
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Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products by Zöller, Katrin, To, Dennis, Bernkop-Schnürch, Andreas

“…Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug…”
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Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin by Zöller, Katrin, To, Dennis, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…[Display omitted] The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various…”
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Corrigendum to “Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense” [J. Colloid Interface Sci. 630(Part B) (2023) 164–178] by To, Dennis, Kakar, Anant, Kali, Gergely, Wibel, Richard, Knoll, Patrick, Marx, Florentine, Bernkop-Schnürch, Andreas

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Dramatic reductions in hepatic steatosis accompanied by improved HbA1c following a 4-week treatment of obese/diabetic/NAFLD patients with DD01, a novel long-acting GLP-1/glucagon receptor agonist by Bell, Adam, To, Dennis, Karanth, Subbu, Sosnovtseva, Svetlana, Lin, Yen-Huei, Shin, Jaehee

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LBP-05 - Dramatic reductions in hepatic steatosis accompanied by improved HbA1c following a 4-week treatment of obese/diabetic/NAFLD patients with DD01, a novel long-acting GLP-1/glucagon receptor agonist by Bell, Adam, To, Dennis, Karanth, Subbu, Sosnovtseva, Svetlana, Lin, Yen-Huei, Shin, Jaehee

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Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense by To, Dennis, Kakar, Anant, Kali, Gergely, Wibel, Richard, Knoll, Patrick, Marx, Florentine, Bernkop-Schnürch, Andreas

“…[Display omitted] Aminoglycosides are well known, cationic antimicrobial drugs. However, biofilm-based antibiotic resistance significantly limits their…”
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72-LB: DD01, a Novel Once-Weekly Dual GLP-1/Glucagon Receptor Agonist, Improves Metabolic Health and Achieves Rapid, Clinically Significant Reductions in Hepatic Steatosis following Only Four Weeks of Treatment and without the Need for Significant Weight Loss in Overweight/Diabetic Subjects with NAFLD by TO, DENNIS, SHIN, JAEHEE, KARANTH, SUBBU, LIN, YEN-HUEI, SOSNOVTSEVA, SVETLANA, BELL, ADAM C.

“…DD01 is a dual GLP-1/glucagon receptor agonist acting through two independent pathways to provide rapid resolution of hepatic steatosis, improve glucose…”
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Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering by Sanchez Armengol, Eva, Hock, Nathalie, Saribal, Sila, To, Dennis, Summonte, Simona, Veider, Florina, Kali, Gergely, Bernkop-Schnürch, Andreas, Laffleur, Flavia

“…Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and…”
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Oral formulations for highly lipophilic drugs: Impact of surface decoration on the efficacy of self-emulsifying drug delivery systems by Sandmeier, Matthias, Hoeng, Julia, Skov Jensen, Sanne, Nykjær Nikolajsen, Gitte, Ziegler Bruun, Heidi, To, Dennis, Ricci, Fabrizio, Schifferle, Michaela, Bernkop-Schnürch, Andreas

“…[Display omitted] To evaluate the impact of the surface decoration of cannabidiol (CBD) loaded self-emulsifying drug delivery systems (SEDDS) on the efficacy…”
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Charge-converting nanocarriers: Phosphorylated polysaccharide coatings for overcoming intestinal barriers by Veider, Florina, To, Dennis, Saleh, Ahmad, Laffleur, Flavia, Kali, Gergely, Hense, Dominik, Strube, Oliver I., Bernkop-Schnürch, Andreas

“…For the design of charge-converting nanocarriers (NCs), cationic lipid-based NCs containing curcumin as model drug were coated with phosphorylated starch…”
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Comparative Analysis of PEG‐Free and PEG‐Based Self‐Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides by Haddadzadegan, Soheil, To, Dennis, Matteo Jörgensen, Arne, Wibel, Richard, Laffleur, Flavia, Bernkop‐Schnürch, Andreas

“…This study aims to compare the potential of Polyethylene glycol (PEG‐free and PEG‐based self‐emulsifying drug delivery systems (SEDDS) for the oral…”
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Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery by Polidori, Ilaria, To, Dennis, Kali, Gergely, Bernkop-Schnürch, Andreas

“…The aim of this study was to design surfactants based on histidine (His) for hydrophobic ion-pairing and evaluate their safety and efficacy. Lauryl, palmitoyl…”
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Safety, tolerability, and efficacy of NLY01 in early untreated Parkinson's disease: a randomised, double-blind, placebo-controlled trial by McGarry, Andrew, Rosanbalm, Shane, Leinonen, Mika, Olanow, C Warren, To, Dennis, Bell, Adam, Lee, Daniel, Chang, Jamie, Dubow, Jordan, Dhall, Rohit, Burdick, Daniel, Parashos, Sotirios, Feuerstein, Jeanne, Quinn, Joseph, Pahwa, Rajesh, Afshari, Mitra, Ramirez-Zamora, Aldolfo, Chou, Kelvin, Tarakad, Arjun, Luca, Corneliu, Klos, Kevin, Bordelon, Yvette, St Hiliare, Marie-Helene, Shprecher, David, Lee, Seulki, Dawson, Ted M, Roschke, Viktor, Kieburtz, Karl

“…Converging lines of evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, justifying exploration of therapeutic agents thought to…”
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Design of biodegradable nanoparticles for enzyme-controlled long-acting drug release by Hock, Nathalie, To, Dennis, Armengol, Eva Sanchez, Summonte, Simona, Seybold, Anna, Federer, Christoph, Bernkop-Schnürch, Andreas

“…The aim of this study was the development of biodegradable polyphosphate nanoparticles as parenteral delivery systems for long-acting drug release by utilizing…”
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Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight heparin by Zöller, Katrin, Laffleur, Flavia, Claus, Victor, Knoll, Patrick, To, Dennis, Bernkop-Schnürch, Andreas

“…The aim of this study was the development and in vivo evaluation of different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH)…”
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Corrigendum to "Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense" J. Colloid Interface Sci. 630(Part B) (2023) 164-178 by To, Dennis, Kakar, Anant, Kali, Gergely, Wibel, Richard, Knoll, Patrick, Marx, Florentine, Bernkop-Schnürch, Andreas

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Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs by Sandmeier, Matthias, Ricci, Fabrizio, To, Dennis, Lindner, Sera, Stengel, Daniel, Schifferle, Michaela, Koz, Saadet, Bernkop-Schnürch, Andreas

“…Abstract It was the aim of this study to evaluate the potential of reverse micelles (RM) and hydrophobic ion pairs (HIP) for incorporation of semaglutide into…”
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The CryoEM structure of human serum albumin in complex with ligands by Catalano, Claudio, Lucier, Kyle W., To, Dennis, Senko, Skerdi, Tran, Nhi L., Farwell, Ashlyn C., Silva, Sabrina M., Dip, Phat V., Poweleit, Nicole, Scapin, Giovanna

“…[Display omitted] •Human serum albumin has a crucial role in regulating biological system.•Understanding HSA-ligand interactions is key for DMPK optimization…”
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Antibiotic-Polyphosphate Nanocomplexes: A Promising System for Effective Biofilm Eradication by To, Dennis, Blanco Massani, Mariana, Coraça-Huber, Débora C, Seybold, Anna, Ricci, Fabrizio, Zöller, Katrin, Bernkop-Schnürch, Andreas

“…The eradication of bacterial biofilms poses an enormous challenge owing to the inherently low antibiotic susceptibility of the resident microbiota. The…”
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