Search Results - "Tiu, Ramon V."

Venetoclax Plus Gilteritinib for FLT3 -Mutated Relapsed/Refractory Acute Myeloid Leukemia by Daver, Naval, Perl, Alexander E, Maly, Joseph, Levis, Mark, Ritchie, Ellen, Litzow, Mark, McCloskey, James, Smith, Catherine C, Schiller, Gary, Bradley, Terrence, Tiu, Ramon V, Naqvi, Kiran, Dail, Monique, Brackman, Deanna, Siddani, Satya, Wang, Jing, Chyla, Brenda, Lee, Paul, Altman, Jessica K

“…The FMS-related tyrosine kinase 3 (FLT3) inhibitor gilteritinib is standard therapy for relapsed/refractory -mutated ( ) acute myeloid leukemia (AML) but…”
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Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis by Makishima, Hideki, Visconte, Valeria, Sakaguchi, Hirotoshi, Jankowska, Anna M., Abu Kar, Sarah, Jerez, Andres, Przychodzen, Bartlomiej, Bupathi, Manoj, Guinta, Kathryn, Afable, Manuel G., Sekeres, Mikkael A., Padgett, Richard A., Tiu, Ramon V., Maciejewski, Jaroslaw P.

“…Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and…”
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An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults by Savona, Michael R., Malcovati, Luca, Komrokji, Rami, Tiu, Ramon V., Mughal, Tariq I., Orazi, Attilio, Kiladjian, Jean-Jacques, Padron, Eric, Solary, Eric, Tibes, Raoul, Itzykson, Raphael, Cazzola, Mario, Mesa, Ruben, Maciejewski, Jaroslaw, Fenaux, Pierre, Garcia-Manero, Guillermo, Gerds, Aaron, Sanz, Guillermo, Niemeyer, Charlotte M., Cervantes, Francisco, Germing, Ulrich, Cross, Nicholas C.P., List, Alan F.

“…Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) are hematologically diverse stem cell malignancies sharing phenotypic features of both…”
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Janus kinase-2 inhibitor fedratinib in patients with myelofibrosis previously treated with ruxolitinib (JAKARTA-2): a single-arm, open-label, non-randomised, phase 2, multicentre study by Harrison, Claire N, Prof, Schaap, Nicolaas, Prof, Vannucchi, Alessandro M, MD, Kiladjian, Jean-Jacques, Prof, Tiu, Ramon V, MD, Zachee, Pierre, Prof, Jourdan, Eric, MD, Winton, Elliott, MD, Silver, Richard T, MD, Schouten, Harry C, Prof, Passamonti, Francesco, MD, Zweegman, Sonja, MD, Talpaz, Moshe, Prof, Lager, Joanne, MD, Shun, Zhenming, PhD, Mesa, Ruben A, FACP

“…Summary Background Myelofibrosis is a chronic myeloproliferative neoplasm characterised by splenomegaly, cytopenias, bone marrow fibrosis, and debilitating…”
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Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms by Wang, Sa A., Hasserjian, Robert P., Fox, Patricia S., Rogers, Heesun J., Geyer, Julia T., Chabot-Richards, Devon, Weinzierl, Elizabeth, Hatem, Joseph, Jaso, Jesse, Kanagal-Shamanna, Rashmi, Stingo, Francesco C., Patel, Keyur P., Mehrotra, Meenakshi, Bueso-Ramos, Carlos, Young, Ken H., Dinardo, Courtney D., Verstovsek, Srdan, Tiu, Ramon V., Bagg, Adam, Hsi, Eric D., Arber, Daniel A., Foucar, Kathryn, Luthra, Raja, Orazi, Attilio

“…Atypical chronic myeloid leukemia (aCML) is a rare subtype of myelodysplastic/myeloproliferative neoplasm (MDS/MPN) largely defined morphologically. It is,…”
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SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes by Visconte, Valeria, Rogers, Heesun J., Singh, Jarnail, Barnard, John, Bupathi, Manoj, Traina, Fabiola, McMahon, James, Makishima, Hideki, Szpurka, Hadrian, Jankowska, Anna, Jerez, Andres, Sekeres, Mikkael A., Saunthararajah, Yogen, Advani, Anjali S., Copelan, Edward, Koseki, Haruhiko, Isono, Kyoichi, Padgett, Richard A., Osman, Sami, Koide, Kazunori, O'Keefe, Christine, Maciejewski, Jaroslaw P., Tiu, Ramon V.

“…Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs)…”
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Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies by Tiu, Ramon V., Gondek, Lukasz P., O'Keefe, Christine L., Elson, Paul, Huh, Jungwon, Mohamedali, Azim, Kulasekararaj, Austin, Advani, Anjali S., Paquette, Ronald, List, Alan F., Sekeres, Mikkael A., McDevitt, Michael A., Mufti, Ghulam J., Maciejewski, Jaroslaw P.

“…Single nucleotide polymorphism arrays (SNP-As) have emerged as an important tool in the identification of chromosomal defects undetected by metaphase…”
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SNP array–based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes by Afable, Manuel G., Wlodarski, Marcin, Makishima, Hideki, Shaik, Mohammed, Sekeres, Mikkael A., Tiu, Ramon V., Kalaycio, Matt, O'Keefe, Christine L., Maciejewski, Jaroslaw P.

“…In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone…”
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An International MDS/MPN Working Group's perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms by Mughal, Tariq I, Cross, Nicholas C P, Padron, Eric, Tiu, Ramon V, Savona, Michael, Malcovati, Luca, Tibes, Raoul, Komrokji, Rami S, Kiladjian, Jean-Jacques, Garcia-Manero, Guillermo, Orazi, Attilio, Mesa, Ruben, Maciejewski, Jaroslaw P, Fenaux, Pierre, Itzykson, Raphael, Mufti, Ghulam, Solary, Eric, List, Alan F

“…In the 2008 WHO classification, chronic myeloid malignancies that share both myelodysplastic and myeloproliferative features define the…”
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Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL by Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben

“…We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL, which is dependent on PI3K and Rho GTPase…”
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Topography, Clinical, and Genomic Correlates of 5q Myeloid Malignancies Revisited by JEREZ, Andres, GONDEK, Lukasz P, MCDEVITT, Michael A, MUFTI, Ghulam J, MACIEJEWSKI, Jaroslaw P, JANKOWSKA, Anna M, MAKISHIMA, Hideki, PRZYCHODZEN, Bartlomiej, TIU, Ramon V, O'KEEFE, Christine L, MOHAMEDALI, Azim M, BATISTA, Denise, SEKERES, Mikkael A

“…Interstitial deletions of chromosome 5q are common in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), pointing toward the pathogenic role of…”
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Clinical outcomes in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia treated with gilteritinib who received prior midostaurin or sorafenib by Perl, Alexander E., Hosono, Naoko, Montesinos, Pau, Podoltsev, Nikolai, Martinelli, Giovanni, Panoskaltsis, Nicki, Recher, Christian, Smith, Catherine C., Levis, Mark J., Strickland, Stephen, Röllig, Christoph, Groß-Langenhoff, Marco, Chou, Wen-Chien, Lee, Je-Hwan, Yokoyama, Hisayuki, Hasabou, Nahla, Lu, Qiaoyang, Tiu, Ramon V., Altman, Jessica K.

“…The fms -like tyrosine kinase 3 (FLT3) inhibitor gilteritinib is indicated for relapsed or refractory (R/R) FLT3 -mutated acute myeloid leukemia (AML), based…”
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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis by Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Mali, Raghuveer Singh, Martin, Holly, Kobayashi, Michihiro, Vemula, Sasidhar, Canela, Victor H., Waskow, Emily R., Visconte, Valeria, Tiu, Ramon V., Smith, Catherine C., Shah, Neil, Bunting, Kevin D., Boswell, H. Scott, Liu, Yan, Chan, Rebecca J., Kapur, Reuben

“…Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms…”
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Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis by Traina, Fabiola, Visconte, Valeria, Jankowska, Anna M, Makishima, Hideki, O'Keefe, Christine L, Elson, Paul, Han, Yingchun, Hsieh, Fred H, Sekeres, Mikkael A, Mali, Raghuveer Singh, Kalaycio, Matt, Lichtin, Alan E, Advani, Anjali S, Duong, Hien K, Copelan, Edward, Kapur, Reuben, Olalla Saad, Sara T, Maciejewski, Jaroslaw P, Tiu, Ramon V

“…We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular defects may provide new insight in the pathogenesis of…”
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Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis by Jerez, Andres, Sugimoto, Yuka, Makishima, Hideki, Verma, Amit, Jankowska, Anna M., Przychodzen, Bartlomiej, Visconte, Valeria, Tiu, Ramon V., O'Keefe, Christine L., Mohamedali, Azim M., Kulasekararaj, Austin G., Pellagatti, Andrea, McGraw, Kathy, Muramatsu, Hideki, Moliterno, Alison R., Sekeres, Mikkael A., McDevitt, Michael A., Kojima, Seiji, List, Alan, Boultwood, Jacqueline, Mufti, Ghulam J., Maciejewski, Jaroslaw P.

“…Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this…”
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A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia by Vadhan-Raj, Saroj, Abonour, Rafat, Goldman, Jonathan W, Smith, David A, Slapak, Christopher A, Ilaria, Jr, Robert L, Tiu, Ramon V, Wang, Xuejing, Callies, Sophie, Cox, Joanne, Tuttle, Jay L, Lau, Yiu-Keung, Roeland, Eric J

“…Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin…”
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Pak and Rac GTPases promote oncogenic KIT-induced neoplasms by Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R, Visconte, Valeria, Tiu, Ramon V, Vlaar, Cornelis P, Dharmawardhane, Suranganie, Kapur, Reuben

“…An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and…”
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New Lesions Detected by Single Nucleotide Polymorphism Array–Based Chromosomal Analysis Have Important Clinical Impact in Acute Myeloid Leukemia by TIU, Ramon V, GONDEK, Lukasz P, ADVANI, Anjali S, MACIEJEWSKI, Jaroslaw P, O'KEEFE, Christine L, HUH, Jungwon, SEKERES, Mikkael A, ELSON, Paul, MCDEVITT, Michael A, XIAO FEI WANG, LEVIS, Mark J, KARP, Judith E

“…Cytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of…”
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Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia by AFABLE, Manuel G, SHAIK, Mohammed, TIU, Ramon V, O'KEEFE, Christine L, MACIEJEWSKI, Jaroslaw P, SUGIMOTO, Yuka, ELSON, Paul, CLEMENTE, Michael, MAKISHIMA, Hideki, SEKERES, Mikkael A, LICHTIN, Alan, ADVANI, Anjali, KALAYCIO, Matt

“…A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. We performed a phase II…”
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Clonal evolution in aplastic anemia by Afable, 2nd, Manuel G, Tiu, Ramon V, Maciejewski, Jaroslaw P

“…Current immunosuppressive treatment (IST) induces remissions in 50%-70% of patients with aplastic anemia (AA) and result in excellent long-term survival. In…”
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