Schistosomiasis Japonica in the Philippines: The Long-Term Impact of Population-Based Chemotherapy on Infection, Transmission, and Morbidity

The long-term impact of annual case-finding and chemotherapy with praziquantel on schistosomiasis japonica was examined in an 8-year longitudinal study in the Philippines. The prevalence, incidence, and intensity of infection and schistosome-induced hepatomegaly significantly decreased within 3–4 ye...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 174; no. 1; pp. 163 - 172
Main Authors:	Olveda, Remigio M., Daniel, Bruce L., Ramirez, Bernadette D. L., Aligui, Gemiliano D. L., Acosta, Luz P., Fevidal, P., Tiu, Edita, Veyra, Federico de, Peters, Pierre A., Romulo, Rodrigo, Domingo, Ernesto, Wiest, Peter M., Olds, G. Richard
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-07-1996 University of Chicago Press Oxford University Press
Subjects:	Adolescent Adult Age Distribution Age groups Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiplatyhelmintic Agents Biological and medical sciences Chemotherapy Child Child, Preschool Female Hepatomegaly Hepatomegaly - parasitology Humans Incidence Infant Infections Longitudinal Studies Major Articles Male Medical sciences Middle Aged Morbidity Patient assessment Pharmacology. Drug treatments Philippines - epidemiology Praziquantel - therapeutic use Prevalence Reinfection Schistosomiasis Schistosomiasis japonica Schistosomiasis japonica - complications Schistosomiasis japonica - drug therapy Schistosomiasis japonica - epidemiology Schistosomiasis japonica - transmission Schistosomicides - therapeutic use Sex Distribution Time Factors Tropical medicine Villages Asia Philippine Islands Philippines Human Prevalence Trematode disease Transmission Plathelmintha Parasitosis Schistosoma japonicum Helminthiasis Long term Trematoda Morbidity Incidence Infection Schistosomiasis Chemotherapy Treatment Parasiticid Helmintha Invertebrata
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Summary:	The long-term impact of annual case-finding and chemotherapy with praziquantel on schistosomiasis japonica was examined in an 8-year longitudinal study in the Philippines. The prevalence, incidence, and intensity of infection and schistosome-induced hepatomegaly significantly decreased within 3–4 years of treatment and then stabilized despite continual population-based chemotherapy. Hepatomegaly rapidly developed in acutely infected persons, with 82% of subjects developing hepatic enlargement within 2 years of reinfection. These data suggest that abrupt discontinuation of current control measures in the Philippines may result in a rapid rebound in morbidity. Age-dependent acquired resistance to reinfection also developed in subjects chronically exposed to schistosomiasis japonica, suggesting that a vaccine may represent an alternative approach for control of this parasitic infection.
Bibliography:	ark:/67375/HXZ-2D9N1HLW-Q Present affiliations: Department of Radiology, Stanford University School of Medicine, Stanford, California (B.L.D.); Program in International Health, MetroHealth Medical Center, Case Western Reserve University, Cleveland (P.M.W.). Reprints or correspondence (present address): Dr. G. Richard Olds, Dept. of Medicine, MetroHealth Medical Center, 2500 MetroHealth Dr., Cleveland, OH 44109-1998. istex:D2845C3AFB1F31F3DC91A2280382C51A9D61A8AA ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/174.1.163