Search Results - "Titov, Denis"

Genetically encoded tools for measuring and manipulating metabolism by Choe, Mangyu, Titov, Denis V.

“…Over the past few years, we have seen an explosion of novel genetically encoded tools for measuring and manipulating metabolism in live cells and animals…”
Get full text

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell by Mick, Eran, Titov, Denis V, Skinner, Owen S, Sharma, Rohit, Jourdain, Alexis A, Mootha, Vamsi K

“…Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically…”
Get full text

A Cellular Mechanism to Detect and Alleviate Reductive Stress by Manford, Andrew G., Rodríguez-Pérez, Fernando, Shih, Karen Y., Shi, Zhuo, Berdan, Charles A., Choe, Mangyu, Titov, Denis V., Nomura, Daniel K., Rape, Michael

“…Metazoan organisms rely on conserved stress response pathways to alleviate adverse conditions and preserve cellular integrity. Stress responses are…”
Get full text

Complementation of mitochondrial electron transport chain by manipulation of the NAD⁺/NADH ratio by Titov, Denis V., Cracan, Valentin, Goodman, Russell P., Peng, Jun, Grabarek, Zenon, Mootha, Vamsi K.

“…A decline in electron transport chain (ETC) activity is associated with many human diseases. Although diminished mitochondrial adenosine triphosphate…”
Get full text

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells by Yang, Xingbo, Heinemann, Matthias, Howard, Jonathon, Huber, Greg, Iyer-Biswas, Srividya, Le Treut, Guillaume, Lynch, Michael, Montooth, Kristi L., Needleman, Daniel J., Pigolotti, Simone, Rodenfels, Jonathan, Ronceray, Pierre, Shankar, Sadasivan, Tavassoly, Iman, Thutupalli, Shashi, Titov, Denis V., Wang, Jin, Foster, Peter J.

“…Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in…”
Get full text

The Warburg Effect is the result of faster ATP production by glycolysis than respiration by Kukurugya, Matthew A., Rosset, Saharon, Titov, Denis V.

“…Many prokaryotic and eukaryotic cells metabolize glucose to organism-specific by-products instead of fully oxidizing it to carbon dioxide and water—a…”
Get full text

A genetically encoded tool for manipulation of NADP+/NADPH in living cells by Cracan, Valentin, Titov, Denis V, Shen, Hongying, Grabarek, Zenon, Mootha, Vamsi K

“…Structure-guided engineering of an NADH oxidase switches its cofactor preference, thus yielding an NADPH oxidase that can be used to tune the cellular NADP +…”
Get full text

XPB, a subunit of TFIIH, is a target of the natural product triptolide by Liu, Jun O, Titov, Denis V, Gilman, Benjamin, He, Qing-Li, Bhat, Shridhar, Low, Woon-Kai, Dang, Yongjun, Smeaton, Michael, Demain, Arnold L, Miller, Paul S, Kugel, Jennifer F, Goodrich, James A

“…Triptolide is a bioactive natural product isolated from plants used in traditional Chinese medicine. A target identification approach shows that triptolide…”
Get full text

Listeria monocytogenes requires cellular respiration for NAD + regeneration and pathogenesis by Rivera-Lugo, Rafael, Deng, David, Anaya-Sanchez, Andrea, Tejedor-Sanz, Sara, Tang, Eugene, Reyes Ruiz, Valeria M, Smith, Hans B, Titov, Denis V, Sauer, John-Demian, Skaar, Eric P, Ajo-Franklin, Caroline M, Portnoy, Daniel A, Light, Samuel H

“…Cellular respiration is essential for multiple bacterial pathogens and a validated antibiotic target. In addition to driving oxidative phosphorylation,…”
Get full text

Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide by He, Qing-Li, Titov, Denis V., Li, Jing, Tan, Minjia, Ye, Zhaohui, Zhao, Yingming, Romo, Daniel, Liu, Jun O.

“…Triptolide is a key component of the traditional Chinese medicinal plant Thunder God Vine and has potent anticancer and immunosuppressive activities. It is an…”
Get full text

Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause by Heestand, Bree, Simon, Matt, Frenk, Stephen, Titov, Denis, Ahmed, Shawn

“…Environmental stress can induce adult reproductive diapause, a state of developmental arrest that temporarily suspends reproduction. Deficiency for C. elegans…”
Get full text

Identification and validation of protein targets of bioactive small molecules by Titov, Denis V., Liu, Jun O.

“…Identification and validation of protein targets of bioactive small molecules is an important problem in chemical biology and drug discovery. Currently, no…”
Get full text

Synthesis of Multivalent Carbohydrate-Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA from Pseudomonas aeruginosa by Gening, Marina L., Titov, Denis V., Cecioni, Samy, Audfray, Aymeric, Gerbst, Alexey G., Tsvetkov, Yury E., Krylov, Vadim B., Imberty, Anne, Nifantiev, Nikolay E., Vidal, Sébastien

“…A family of fifteen glycoclusters based on a cyclic oligo‐(1→6)‐β‐D‐glucosamine core has been designed as potential inhibitors of the bacterial lectin LecA…”
Get full text

Trimodal Control of Ion-Transport Activity on Cyclo-oligo-(1→6)-β-D-glucosamine-Based Artificial Ion-Transport Systems by Roy, Arundhati, Saha, Tanmoy, Gening, Marina L., Titov, Denis V., Gerbst, Alexey G., Tsvetkov, Yury E., Nifantiev, Nikolay E., Talukdar, Pinaki

“…Cyclo‐oligo‐(1→6)‐β‐D‐glucosamines functionalized with hydrophobic tails are reported as a new class of transmembrane ion‐transport system. These macrocycles…”
Get full text

Cyclo-oligo-(1 → 6)-β-D-glucosamine based artificial channels for tunable transmembrane ion transport by Saha, Tanmoy, Roy, Arundhati, Gening, Marina L, Titov, Denis V, Gerbst, Alexey G, Tsvetkov, Yury E, Nifantiev, Nikolay E, Talukdar, Pinaki

“…Unimolecular ion channels were designed by functionalization of a new type of cyclic oligosaccharides, cyclo-oligo-(1 → 6)-β-d-glucosamines, with pentabutylene…”
Get more information

Analyzing protein kinase dynamics in living cells with FRET reporters by Ni, Qiang, Titov, Denis V., Zhang, Jin

“…Genetically encoded reporters based on fluorescence resonance energy transfer (FRET) are being developed for analyzing spatiotemporal dynamics of kinase…”
Get full text

Stereochemistry of intramolecular cyclization of tetra-β-(1→6)-d-glucosamines and related tetrasaccharides: the role of the conformational stereocontrol and the neighboring group participation by Titov, Denis V., Gening, Marina L., Gerbst, Alexey G., Chizhov, Alexander O., Tsvetkov, Yury E., Nifantiev, Nikolay E.

“…[Display omitted] • Cyclization of tetra-β-(1→6)-d-glucosamines and their Glc-analogues was studied. • The effect of reaction conditions on stereochemistry of…”
Get full text

Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP by Liu, Jun O., Titov, Denis V., Dang, Yongjun, He, Qingli

“…In this issue of Molecular Cell, Ahearn et al. (2011) identified FKBP12 as a novel regulator of Ras signaling through its modulation of depalmitoylation of…”
Get full text

The Mechanism of Low-Temperature Oxidation of Carbon Monoxide by Oxygen over the PdCl₂-CuCl₂/γ-Al₂O₃ Nanocatalyst by Bruk, Lev, Titov, Denis, Ustyugov, Alexander, Zubavichus, Yan, Chernikova, Valeriya, Tkachenko, Olga, Kustov, Leonid, Murzin, Vadim, Oshanina, Irina, Temkin, Oleg

“…The state of palladium and copper on the surface of the PdCl₂-CuCl₂/γ-Al₂O₃ nanocatalyst for the low-temperature oxidation of CO by molecular oxygen was…”
Get full text

NMR and conformational studies of linear and cyclic oligo-(1→6)-β- d-glucosamines by Grachev, Alexey A., Gerbst, Alexey G., Gening, Marina L., Titov, Denis V., Yudina, Olga N., Tsvetkov, Yury E., Shashkov, Alexander S., Pier, Gerald B., Nifantiev, Nikolay E.

“…The conformational behavior of a series of linear and cyclic oligo-(1→6)-β- d-glucosamines and their N-acetylated derivatives, which are related to fragments…”
Get full text